Ubrelvy (ubrogepant) is a prescription drug used for immediate migraine symptom treatment. Ubrelvy comes as an oral tablet.
To learn more about Ubrelvy’s uses, see the “Is Ubrelvy used for migraine?” section below.
Ubrelvy is a brand-name medication. It contains the active ingredient ubrogepant. (An active ingredient is what makes a drug work.) A generic version of the drug isn’t currently available.
Ubrelvy belongs to a group of drugs called calcitonin gene-related peptide antagonists.
Like most drugs, Ubrelvy may cause mild or serious side effects. The lists below describe some of the more common side effects that Ubrelvy may cause. These lists don’t include all possible side effects.
The side effects of a drug can vary from person to person. And they depend on:
- your age
- your overall health
- other medications you may be taking
- the dosage of medication you’re taking
- other factors
Your doctor or pharmacist can tell you more about the possible side effects of Ubrelvy. They can also suggest ways to help reduce the drug’s side effects.
Mild side effects
Here’s a list of some of the mild side effects that Ubrelvy can cause. To learn about other mild side effects, talk with your doctor or pharmacist or read Ubrelvy’s prescribing information.
Mild side effects* of Ubrelvy can include:
Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.
* For more information about these side effects, see the “Side effect focus” section below.
Serious side effects
Serious side effects from Ubrelvy can occur, but they aren’t common. If you have serious side effects from Ubrelvy, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number.
In rare cases, some people may experience an allergic reaction to Ubrelvy. The most severe type of allergic reaction, called anaphylaxis, may be life threatening. For more information about allergic reaction, see the “Side effect focus” section just below.
Side effect focus
Before starting Ubrelvy, be sure to discuss any concerns you have about side effects with your doctor. This will help you decide together if taking the medication is right for you.
Here’s information about some side effects of Ubrelvy.
You may feel tired or sleepy while taking Ubrelvy. This is a common side effect of the drug. In studies, this was reported more often with a higher dosage of the drug than with a lower dosage.
Keep in mind that migraine, which Ubrelvy is used to treat, can lead to tiredness and fatigue (lack of energy). So, it’s important to ask your doctor or pharmacist what you can expect with Ubrelvy treatment.
What might help
Until you become familiar with how Ubrelvy affects you, use caution when participating in activities during which you’ll need to be mentally alert or focused. This could include activities such as driving or operating machinery.
If this is a concern for you, ask your doctor for tips on how to help. They may recommend things like taking a walk or trying energizing deep breathing exercises.
In rare cases, Ubrelvy may make you dizzy. And certain symptoms of migraine may cause or worsen dizziness. These migraine symptoms include tiredness, fatigue, nausea, and vomiting.
What might help
While your body gets used to Ubrelvy, try the following things to help manage dizziness:
- Lie down until your dizziness goes away.
- To avoid falling, be careful when standing up from a sitting position.
- Drink plenty of water.
Talk with your doctor or pharmacist about other ways to help manage dizziness while you’re using Ubrelvy.
You may have nausea while you’re taking Ubrelvy. In studies, nausea was the most commonly reported side effect of Ubrelvy.
But keep in mind that migraine can also cause nausea and vomiting. So, it’s important to discuss with your doctor how treatment with Ubrelvy may affect you.
What might help
If you’re concerned about having nausea, talk with your doctor before taking Ubrelvy. They can recommend some things to help ease nausea.
For instance, your doctor may suggest things like:
- trying natural options, including controlled breathing, massage, relaxation techniques, or cool compresses or ice
- taking anti-nausea medications, such as ondansetron (Zofran) or promethazine
It’s possible to have xerostomia (dry mouth) with Ubrelvy treatment. This occurs when there’s not enough saliva in your mouth. And it can cause uncomfortable effects, including cracked lips, a dry throat, and bad breath.
What might help
Some simple tips that may help relieve your dry mouth symptoms include the following:
- Drink more water than usual.
- Limit your intake of caffeine, tobacco, and alcohol.
- Cut down on salt and sugar intake.
- Use an over-the-counter mouthwash.
Be sure to talk with your doctor if dry mouth bothers you while you’re using Ubrelvy. They may offer more suggestions to help relieve this side effect.
Some people may have an allergic reaction to Ubrelvy.
Symptoms of a mild allergic reaction can include:
- skin rash
- flushing (temporary warmth, redness, or deepening of skin color)
A more severe allergic reaction called anaphylaxis is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat, which can cause trouble breathing
- hives and itchy skin
Call your doctor right away if you have an allergic reaction to Ubrelvy. But if you think you’re having a medical emergency, call 911 or your local emergency number.
Whether you have health insurance or not, cost may be a factor when you’re considering Ubrelvy. What you’ll pay for Ubrelvy may depend on several things, such as your treatment plan and the pharmacy you use.
Here are a few things to consider regarding cost:
- Cost information and savings coupons. You can visit Optum Perks* to get price estimates of what you’d pay for Ubrelvy when using coupons from the site.
- Savings program. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. A savings program may also be available on the drug’s website.
You can also check out this article to learn more about saving money on prescriptions.
* Optum Perks is a sister site of Healthline. Optum Perks coupons cannot be used with any insurance copays or benefits.
To save money on your Ubrelvy prescription, explore these Optum Perks coupons.
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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.
Optum Perks and Healthline are subsidiaries of RVO Health.
Your doctor will recommend the dosage of Ubrelvy that’s right for you. Below are commonly used dosages, but always follow the dosage instructions that your doctor provides.
Form and strengths
Ubrelvy comes as a tablet you swallow. It’s available in the following strengths:
- 50 milligrams (mg)
- 100 mg
You’ll take a dose of Ubrelvy when you need immediate treatment for a migraine episode. Then, you can take a second dose 2 hours after your first dose, if needed.
You should not take more than 200 milligrams of the drug within a 24-hour timeframe. (This is the maximum dosage of the drug.)
Also, you should not take Ubrelvy for more than eight migraine episodes in 30 days. The safety of taking Ubrelvy more often than this isn’t known. So, talk with your doctor about how often you should take this drug.
Note: You should avoid taking a second dose of Ubrelvy if you’ve drank any grapefruit juice or eaten any grapefruit within 24 hours of your first dose. Doing so may increase the side effects of Ubrelvy. This is because grapefruit makes the drug stay in your body for longer than usual and can increase its side effects.
To learn more about Ubrelvy’s dosage, see this article.
Questions about Ubrelvy’s dosage
Here are answers to a few common questions about Ubrelvy’s dosage:
- What if I miss a dose of Ubrelvy? Ubrelvy is taken for immediate treatment of migraine symptoms. It’s not meant to be used for migraine prevention. So you don’t have to take it every day. Instead, you’ll just take it when you need it.
- Will I need to take Ubrelvy long term? If Ubrelvy works well for you, your doctor may recommend that you take it long term, as needed, for migraine episodes. You should discuss your migraine treatment plan with your doctor.
- How long does Ubrelvy take to work? Ubrelvy starts to work quickly. Most people get relief from migraine symptoms within 2 hours of taking a dose. And the effects of Ubrelvy may last for up to a day or longer.
Ubrelvy is used to manage migraine in adults. Specifically, it’s used for immediate treatment of migraine symptoms. It’s not used to prevent migraine episodes.
Other drugs are used to treat migraine episodes. Examples include:
- rimegepant (Nurtec ODT)
- eletriptan (Relpax)
- lasmiditan (Reyvow)
- triptans, such as rizatriptan (Maxalt and Maxalt-MLT) and sumatriptan (Imitrex)
Some examples of medications that prevent migraine episodes include:
To learn more about alternative drugs to manage migraine, see this article. Also, talk with your doctor about which drug is right for you.
For more information about Ubrelvy vs. Imitrex, see the “What are some frequently asked questions about Ubrelvy?” section directly below.
Below, we answer some common questions related to Ubrelvy use.
How does Ubrelvy work? What’s its half-life?
Ubrelvy belongs to a group of drugs called CGRP antagonists. The mechanism of action for these drugs is to block the effects of a protein in your body called CGRP. (The mechanism of action describes how a drug works.)
Because CGRP is responsible for pain and inflammation tied to migraine, scientists theorize that medications such as Ubrelvy work by blocking CGRP. Levels of CGRP are increased during migraine episodes. And Ubrelvy helps bring these levels down.
Ubrelvy has a half-life of 5 to 7 hours. This means your body will clear half of a dose of the drug 5 to 7 hours after you take your dose. It takes about five half-lives for your body to fully clear a drug.
If you have more questions about how Ubrelvy works, talk with your doctor.
How does Ubrelvy compare with Imitrex?
Ubrelvy belongs to a group of drugs called calcitonin gene-related peptide (CGRP) antagonists. It works by blocking a specific protein in your body. (To learn more about how Ubrelvy works, see the “How does Ubrelvy work?” question above.) Imitrex, on the other hand, belongs to a group of drugs called serotonin 1 receptor agonists. It works by increasing your serotonin levels and narrowing blood vessels in your brain.
Ubrelvy is a newer medication, and it’s only available as a brand-name drug. It doesn’t come as a generic drug. But Imitrex has been around for a longer period of time. And it’s available in both brand-name and generic versions.
While Ubrelvy only comes as an oral tablet, Imitrex comes as an injectable solution, a nasal spray, and an oral tablet.
These two medications have different side effects, but they also have a few similar side effects. Their similar side effects include nausea and dry mouth. To learn more about the side effects of Imitrex, view the prescribing information for the injectable solution, nasal spray, or oral tablet. And for more information about Ubrelvy’s side effects, see the “What are Ubrelvy’s side effects?” section above.
Keep in mind that not every medication works for every person. So, having different treatment choices can help you and your doctor find the best option for you. If you have questions about the differences between Ubrelvy and Imitrex and wonder how they might help your migraine symptoms, talk with your doctor.
Is Ubrelvy a triptan?
If you’d like to know about taking a triptan for migraine treatment, talk with your doctor.
Is Ubrelvy a controlled substance?
No, Ubrelvy isn’t a controlled substance. Controlled substances have the potential to be misused. (With misuse, a drug is taken in a way other than how it’s prescribed.) But Ubrelvy doesn’t carry a risk of misuse.
Lasmiditan (Reyvow) is an example of a migraine drug that’s a controlled substance.
Does Ubrelvy cause weight loss?
Keep in mind that migraine episodes can cause nausea and vomiting. In some cases, these symptoms could lead to weight loss.
If you’re having weight loss with Ubrelvy, talk with your doctor. They can recommend ways to help you manage a weight that’s healthy for you.
Is Ubrelvy used for tension headaches?
If you’d like to learn about treatment options for tension headaches, talk with your doctor.
With migraine, you can have symptoms such as severe headaches, nausea, vomiting, and visual or sensory changes called an aura. Ubrelvy can treat migraine episodes that happen with or without an aura.
Ubrelvy works to relieve migraine symptoms by blocking the activity of a specific protein in your body.
Sometimes, doctors treat conditions other than migraine with Ubrelvy. Doing so would be prescribing the drug off-label. (With off-label drug use, a drug that’s approved for certain conditions is prescribed for another condition.)
If you have questions about how Ubrelvy is used, talk with your doctor.
Your doctor will explain how you should take Ubrelvy. They’ll also explain how much to take and how often to take it. Be sure to follow your doctor’s instructions.
Ubrelvy comes as tablets that you swallow. You should take the medication as soon as you feel a migraine episode starting.
It’s important to note that you should avoid taking a second dose of Ubrelvy if you’ve drank any grapefruit juice or eaten any grapefruit within 24 hours of your first dose. Doing so may increase the side effects of Ubrelvy. This is because grapefruit makes the drug stay in your body for longer than usual and can increase its side effects.
Questions about taking Ubrelvy
Here are some answers to a few common questions related to taking Ubrelvy:
- Can Ubrelvy be chewed, crushed, or split? No, you shouldn’t crush, chew, or split Ubrelvy tablets. It’s not known if doing these things will change how the medication works. If you have trouble swallowing pills, talk with your doctor about other treatment options.
- Should I take Ubrelvy with food? You can take Ubrelvy with or without food. But keep in mind that both Ubrelvy and migraine may cause nausea. So, you’ll have to find out how well your body tolerates Ubrelvy either with food or on an empty stomach.
There aren’t any known interactions between Ubrelvy and alcohol. But using both together may increase some side effects of Ubrelvy. These can include:
- dry mouth
Also, keep in mind that for some people, alcohol can increase the risk of a migraine episode. And Ubrelvy is taken for immediate treatment of migraine symptoms.
Talk with your doctor about what you should know about drinking alcohol while taking Ubrelvy.
Using certain medications, vitamins, or foods alongside certain drugs can affect how they all work. These effects are called interactions.
Interactions can change a drug’s effect in your body. And this can lead to two possible outcomes:
- the drug’s effect being lowered so that it doesn’t work as well as usual
- the drug’s effect being raised so that it lasts for longer in your body and may cause increased side effects
Before taking Ubrelvy, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also, describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Ubrelvy.
Interactions with drugs or supplements
Ubrelvy can interact with certain drugs in a way that leads to increased effects of Ubrelvy in your body. These drugs include:
- certain HIV medications, such as cobicistat, ritonavir, and nelfinavir mesylate
- certain antibiotics, including ciprofloxacin
- antifungals, such as fluconazole
- the blood pressure drug verapamil
- the immunosuppressant drug cyclosporine
- the antidepressant drug fluvoxamine
Ubrelvy can also interact with certain medications in a way that leads to lower effects of Ubrelvy in your body. These drugs include:
These lists do not contain all types of drugs that may interact with Ubrelvy. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of Ubrelvy.
Note: Taking certain medications with Ubrelvy is contraindicated. (A contraindication is a factor or condition that could prevent your doctor from prescribing a drug due to a risk of harm.) Ask your doctor for more information about medications that are contraindicated with Ubrelvy.
In addition to the medications described above, Ubrelvy can also interact with other substances. For example:
Ubrelvy may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you take Ubrelvy. Some factors to consider include those in the list below:
- Liver or kidney disease. If you have problems with kidney or liver function, your body may not be able to clear Ubrelvy like usual. And this could increase the amount of Ubrelvy in your body, thereby increasing side effects from the drug. Depending on how your kidney and liver are working, your doctor may adjust your dosage of Ubrelvy. Your doctor can also order blood tests to check the health of your liver and your kidneys before prescribing Ubrelvy to you.
- Allergic reaction. If you’ve had an allergic reaction to Ubrelvy or any of its ingredients, your doctor won’t prescribe Ubrelvy for your condition. Ask your doctor about which other medications are better options for you.
There isn’t enough information available about the effects of taking Ubrelvy during pregnancy or while breastfeeding. If you’re pregnant or breastfeeding, or planning to become pregnant or to breastfeed, talk with your doctor about the safety of taking Ubrelvy.
Do not take more Ubrelvy than your doctor prescribes. Doing so can lead to serious side effects.
In any case, don’t take more Ubrelvy than your doctor prescribes.
What to do in case you take too much Ubrelvy
Call your doctor if you think you’ve taken too much Ubrelvy. You can also call 800-222-1222 to reach America’s Poison Centers, or you can use its online resource. But if you have severe symptoms, immediately call 911 or your local emergency number. Or go to the nearest emergency room.
Before starting Ubrelvy, talk with your doctor about the risks and benefits of using this drug. And keep in mind that there are many different options for migraine treatment and prevention. Some of these options include natural remedies, while others include alternative medications.
Here are a few resources on migraine that you might find helpful to explore:
Ubrelvy is a fairly new medication, so you may have questions about how it works and how it’s used for migraine. A few questions you might consider asking your doctor include:
- Does food slow down how long it takes Ubrelvy to start working?
- How many doses of Ubrelvy can I take in 1 day?
- Will Ubrelvy make me too sleepy to drive or work?
To learn more about Ubrelvy, see these articles:
- Dosage Details for Ubrelvy
- Side Effects of Ubrelvy: What You Need to Know
- Ubrelvy and Cost: What You Need to Know
- Ubrelvy Interactions: Alcohol, Medications, and Others
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Can I take Ubrelvy with acetaminophen (Tylenol) or ibuprofen (Motrin)?Anonymous
There aren’t any known interactions between Ubrelvy and acetaminophen (Tylenol) or ibuprofen (Motrin). But you should only take Ubrelvy with an additional pain medication like these if your doctor says to do so. Keep in mind that Ubrelvy is approved to treat a migraine episode on its own without other drugs.The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.