Ubrelvy Interactions: Alcohol, Medications, and Others

Certain health conditions or other factors could raise your risk of harm if you take Ubrelvy. In that case, your doctor may not prescribe Ubrelvy for you. This is known as a contraindication. The list below includes contraindications of Ubrelvy.

If you take certain drugs called strong CYP3A4 inhibitors. When you take a dose of Ubrelvy, certain enzymes (proteins) in your body break down the medication. Specifically, the CYP3A4 enzyme helps break down Ubrelvy after you take a dose.

Certain medications block CYP3A4 from working. These medications are referred to as CYP3A4 inhibitors. Some of these medications greatly affect CYP3A4 and how well it works. This can result in Ubrelvy levels building up in your body, which may raise your risk of side effects. Drugs that act in this way are called strong CYP3A4 inhibitors.

Examples of strong CYP3A4 inhibitors include:

• ketoconazole
• itraconazole (Sporanox, Tolsura)
• clarithromycin

Because of this risk, doctors typically will not prescribe Ubrelvy with a strong CYP3A4 inhibitor. They may also adjust your dose if you need to take Ubrelvy with a weak or moderate CYP3A4 inhibitor. Before you begin treatment with Ubrelvy, it’s important to tell your doctor about all medications and supplements you take.

Your doctor may recommend that you stop using the strong CYP3A4 inhibitor and switch to a different treatment instead. Or they may prescribe a migraine treatment other than Ubrelvy.

If you’ve had an allergic reaction. If you have had a severe allergic reaction to Ubrelvy or any of its ingredients, your doctor likely won’t prescribe Ubrelvy. This is because taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better options for you.

Before you start taking Ubrelvy, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Ubrelvy is safe for you to take.

There’s no known interaction between Ubrelvy and alcohol. But Ubrelvy and alcohol can cause some of the same side effects, including nausea and sleepiness. Combining Ubrelvy and alcohol may raise your risk of these side effects or make them worse if you do experience them.

For some people, alcohol is a trigger for a migraine episode. And it’s possible that drinking alcohol during a migraine episode could worsen your symptoms.

If you drink alcohol, talk with your doctor about how much may be safe to drink with your condition and treatment plan.

Before you start taking Ubrelvy, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions.

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The chart below lists drugs that may interact with Ubrelvy. Keep in mind that this chart does not include all drugs that may interact with Ubrelvy. For more information about some of these interactions, see the “Drug interactions explained” section below.

Learn more about certain drug interactions that can occur with Ubrelvy.

Interaction with drugs that raise the risk of side effects from Ubrelvy

Taking Ubrelvy with certain drugs can raise your risk of side effects. See below for more details.

What you can do

Before you begin using Ubrelvy, tell your doctor and pharmacist about all medications you take. They’ll check to see whether any of them may raise your risk of side effects from Ubrelvy.

If you’re taking a drug that could interact with Ubrelvy in this way, your doctor will likely lower your Ubrelvy dosage. (To learn more about Ubrelvy’s dosage, see this article.) In some cases, your doctor may prescribe a drug other than Ubrelvy to treat your condition.

Interaction with drugs that can make Ubrelvy less effective

When certain drugs are taken with Ubrelvy, they can make Ubrelvy less effective. See below for more details.

What you can do

Before taking Ubrelvy, tell your doctor about all the medications you take. They can determine whether any of them could make Ubrelvy less effective if taken together.

If you’re taking a drug that could interact with Ubrelvy in this way, your doctor may raise your Ubrelvy dosage. Or in some cases, they may prescribe a drug other than Ubrelvy to treat your condition.

Ubrelvy may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details.

Does Ubrelvy interact with supplements?

Before you start taking Ubrelvy, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Ubrelvy interactions with herbs

The herbal supplements St. John’s wort and curcumin (which is found in turmeric) can interact with Ubrelvy.

Taking Ubrelvy with St. John’s wort can make Ubrelvy less effective.

Because of this risk, doctors will usually recommend that you don’t use St. John’s wort with Ubrelvy. Instead, they can recommend alternatives to either St. John’s wort or Ubrelvy.

Taking Ubrelvy with curcumin could raise your risk of side effects from Ubrelvy. Because of this risk, your doctor will likely lower your Ubrelvy dosage if you take it with a curcumin or turmeric supplement. (To learn more about Ubrelvy’s dosage, see this article.)

Ubrelvy and vitamins

There are currently no reports of Ubrelvy interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Ubrelvy.

Does Ubrelvy interact with food?

Grapefruit and grapefruit juice may interact with Ubrelvy. Eating grapefruit while taking Ubrelvy may make the drug stay in your body longer. This can increase your risk of side effects from Ubrelvy, such as nausea.

If you consume grapefruit or grapefruit juice, your doctor will likely ask you to avoid these products during your Ubrelvy treatment. Or in some cases, they may lower your Ubrelvy dosage. Your doctor will also likely tell you to avoid taking a second Ubrelvy dose in one day if you’ve consumed grapefruit. (To learn more about Ubrelvy’s dosage, see this article.)

If you have questions about eating grapefruit with Ubrelvy, talk with your doctor.

Does Ubrelvy interact with vaccines?

Ubrelvy isn’t known to interact with any vaccines.

Does Ubrelvy interact with lab tests?

Ubrelvy isn’t known to interact with any lab tests.

Does Ubrelvy interact with cannabis or CBD?

Ubrelvy can interact with cannabis (marijuana) or cannabis products such as cannabidiol (CBD). Combining Ubrelvy with cannabis can increase the amount of Ubrelvy in your body and raise your risk of side effects. If you use cannabis, talk with your doctor about the risks of using it with Ubrelvy.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Ubrelvy. Before taking Ubrelvy, talk with your doctor about your health history. They’ll determine whether Ubrelvy is right for you.

Health conditions or other factors that might interact with Ubrelvy include:

• Kidney problems. Your kidneys play a key role in removing Ubrelvy from your body after you take a dose. If you have kidney problems, such as chronic kidney disease, Ubrelvy levels could build up in your body. This may raise your risk of side effects, such as sleepiness. If your kidney problems are severe, your doctor will likely prescribe a lower Ubrelvy dosage for you. But if you have end-stage kidney disease, your doctor will likely suggest a treatment other than Ubrelvy for migraine.
• Liver problems. Your liver also plays an important role in getting rid of Ubrelvy after you take a dose. If you have liver problems (such as alcohol-related liver disease), Ubrelvy levels may build up in your body. This could raise your risk of side effects, such as fatigue. If you have a severe liver problem, your doctor will likely prescribe a lower Ubrelvy dosage for you.
• Pregnancy. It’s unknown whether it’s safe to take Ubrelvy while pregnant. If you’re pregnant or can become pregnant, talk with your doctor before taking Ubrelvy.
• Breastfeeding. It’s not known whether it’s safe to breastfeed while taking Ubrelvy. If you’re currently breastfeeding or planning to breastfeed, talk with your doctor before taking Ubrelvy.
• Allergic reaction. If you’ve had a severe allergic reaction to Ubrelvy or any of its ingredients, your doctor will likely not prescribe Ubrelvy. This is because taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Ubrelvy. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

• Whether you drink alcohol or use cannabis.
• Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
• What to do if you start taking a new drug during your Ubrelvy treatment.

It’s also important to read Ubrelvy’s label and other paperwork that comes with the drug. You may see colored stickers on the label that describe interactions. And the paperwork (sometimes called the prescribing information) may have other details about interactions. If you need help understanding this information, your doctor or pharmacist can help.

Taking Ubrelvy exactly as prescribed can also help prevent interactions.

If you still have questions about Ubrelvy and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

• Could I still take Ubrelvy even if it interacts with a health condition I have? Would a lower dose be safe for me to take?
• Is it safe to take Ubrelvy if I have high blood pressure?
• Do other drugs that could treat my condition have similar interactions?
• Will my dosage of Ubrelvy affect my risk of interactions?

To learn more about Ubrelvy, see these articles:

• All About Ubrelvy
• Dosage Details for Ubrelvy
• Side Effects of Ubrelvy: What You Need to Know
• Ubrelvy and Cost: What You Need to Know

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.