Kidneys are responsible for regulating pH, salt, potassium, and more. Various diseases, lifestyle habits, and genetic factors can affect kidney function.

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The kidneys are a pair of fist-sized organs located at the bottom of the rib cage. There is one kidney on each side of the spine.

Kidneys are essential to having a healthy body. They are mainly responsible for filtering waste products, excess water, and other impurities out of the blood. These toxins are stored in the bladder and then removed during urination.

The kidneys also regulate pH, salt, and potassium levels in the body. They produce hormones that regulate blood pressure and control the production of red blood cells. The kidneys even activate a form of vitamin D that helps the body absorb calcium.

Kidney disease affects approximately 37 million American adults. It occurs when your kidneys become damaged and cannot perform their function. Damage may be caused by diabetes, high blood pressure, and various other long-term (chronic) conditions.

Kidney disease can lead to other health problems, including weak bones, nerve damage, and malnutrition.

If the disease gets worse over time, your kidneys may stop working completely. This means that dialysis will be required to perform the function of the kidneys. Dialysis is a treatment that filters and purifies the blood using a machine. It cannot cure kidney disease, but it can prolong your life.

Chronic kidney disease

The most common form of kidney disease is chronic kidney disease. Chronic kidney disease is a long-term condition that does not improve over time. It’s commonly caused by high blood pressure.

High blood pressure is dangerous for the kidneys because it can increase the pressure on the glomeruli. Glomeruli are the tiny blood vessels in the kidneys where blood is cleaned. Over time, the increased pressure damages these vessels, and kidney function begins to decline.

Kidney function will eventually deteriorate to the point where the kidneys can no longer perform their job properly. In this case, a person would need to go on dialysis. Dialysis filters extra fluid and waste out of the blood. Dialysis can help treat kidney disease, but it cannot cure it.

A kidney transplant may be another treatment option depending on your circumstances.

Diabetes is also a major cause of chronic kidney disease. Diabetes is a group of diseases that causes high blood sugar. The increased level of sugar in the blood damages the blood vessels in the kidneys over time. This means the kidneys cannot clean the blood properly. Kidney failure can occur when your body becomes overloaded with toxins.

Kidney stones

Kidney stones are another common kidney problem. They occur when minerals and other substances in the blood crystallize in the kidneys, forming solid masses (stones). Kidney stones usually come out of the body during urination. Passing kidney stones can be extremely painful, but they rarely cause significant problems.


Glomerulonephritis is an inflammation of the glomeruli. Glomeruli are extremely small structures inside the kidneys that filter the blood. Glomerulonephritis can be caused by infections, drugs, or disorders that occur during or shortly after birth (congenital abnormalities). It often gets better on its own.

Polycystic kidney disease

Polycystic kidney disease is a genetic disorder that causes numerous cysts (small sacs of fluid) to grow in the kidneys. These cysts can interfere with kidney function and cause kidney failure.

It’s important to note that individual kidney cysts are fairly common and almost always harmless. Polycystic kidney disease is a separate, more serious condition.

Urinary tract infections

Urinary tract infections (UTIs) are bacterial infections of any part of the urinary system. Infections in the bladder and urethra are the most common. They are easily treatable and rarely lead to more health problems. However, if left untreated, these infections can spread to the kidneys and cause kidney failure.

Kidney disease is a condition that can easily go unnoticed until the symptoms become severe. The following symptoms are early warning signs that you might be developing kidney disease:

  • fatigue
  • difficulty concentrating
  • trouble sleeping
  • poor appetite
  • muscle cramping
  • swollen feet and ankles
  • puffiness around the eyes in the morning
  • dry, scaly skin
  • frequent urination, especially late at night

Severe symptoms that could mean your kidney disease is progressing into kidney failure include:

  • nausea
  • vomiting
  • loss of appetite
  • changes in urine output
  • fluid retention
  • anemia (a decrease in red blood cells)
  • decreased sex drive
  • sudden rise in potassium levels (hyperkalemia)
  • inflammation of the pericardium (fluid-filled sac that covers the heart)

People with diabetes have a higher risk of developing kidney disease. Diabetes is the leading cause of kidney disease, accounting for about 44 percent of new cases. You may also be more likely to get kidney disease if you:

  • have high blood pressure
  • have other family members with chronic kidney disease
  • are elderly

Research indicates that kidney disease occurs more often in people of African American, Hispanic, Asian, and American Indian descent.

Your doctor will first determine whether you are at a higher risk of developing kidney disease. They will then run some tests to see if your kidneys are functioning properly. These tests may include:

Glomerular filtration rate (GFR)

This test will measure how well your kidneys are working and determine the stage of kidney disease.

Ultrasound or computed tomography (CT) Scan

Ultrasounds and CT scans produce clear images of your kidneys and urinary tract. The pictures allow your doctor to see if your kidneys are too small or large. They can also show any tumors or structural problems that may be present.

Kidney biopsy

During a kidney biopsy, your doctor will remove a small piece of tissue from your kidney while you’re sedated. The tissue sample can help your doctor determine the type of kidney disease you have and how much damage has occurred.

Urine test

Your doctor may request a urine sample to test for albumin. Albumin is a protein that can be passed into your urine when your kidneys are damaged.

Blood creatinine test

Creatinine is a waste product. It’s released into the blood when creatine (a molecule stored in muscle) is broken down. The levels of creatinine in your blood will increase if your kidneys aren’t working properly.

Treatment for kidney disease usually focuses on controlling the underlying cause of the disease. This means your doctor will help you better manage your blood pressure, blood sugar, and cholesterol levels. They may use one or more of the following methods to treat kidney disease.

Drugs and medication

Your doctor will either prescribe angiotensin-converting enzyme (ACE) inhibitors, such as lisinopril and ramipril, or angiotensin receptor blockers (ARBs), such as irbesartan and olmesartan. These are blood pressure medications that can slow the progression of kidney disease.

Your doctor may prescribe these medications to preserve kidney function, even if you don’t have high blood pressure.

You may also be treated with cholesterol drugs (such as simvastatin). These medications can reduce blood cholesterol levels and help maintain kidney health. Depending on your symptoms, your doctor may also prescribe drugs to relieve swelling and treat anemia (decrease in the number of red blood cells).

Dietary and lifestyle changes

Making changes to your diet is just as important as taking medication. Adopting a lifestyle with health-promoting benefits can help prevent many of the underlying causes of kidney disease. Your doctor may recommend that you:

  • manage diabetes through insulin injections
  • limit foods high in cholesterol
  • reduce salt intake
  • eat a heart-healthy diet that includes fresh fruits, veggies, whole grains, and low fat dairy products
  • limit alcohol consumption
  • quit smoking if you smoke
  • stay as physically active as possible
  • maintain a moderate weight

Dialysis is an artificial method of filtering the blood. It’s used when the kidneys have failed or are close to failing. Many people with late-stage kidney disease must go on dialysis permanently or until a donor kidney is found.

There are two types of dialysis: hemodialysis and peritoneal dialysis.


In hemodialysis, the blood is pumped through a special machine that filters out waste products and fluid. Hemodialysis is done at your home or in a hospital or dialysis center. Most people have three sessions per week, with each session lasting 3 to 5 hours. However, hemodialysis can also be done in shorter, more frequent sessions.

Several weeks before starting hemodialysis, most people will have surgery to create an arteriovenous (AV) fistula. An AV fistula is created by connecting an artery and a vein just below the skin, typically in the forearm. The larger blood vessel allows an increased amount of blood to flow continuously through the body during hemodialysis treatment.

This means more blood can be filtered and purified. An arteriovenous graft (a looped, plastic tube) may be implanted and used for the same purpose if an artery and vein cannot be joined together.

The most common side effects of hemodialysis are low blood pressure, muscle cramping, and itching.

Peritoneal dialysis

In peritoneal dialysis, the peritoneum (membrane that lines the abdominal wall) stands in for the kidneys. A tube is implanted and used to fill the abdomen with a fluid called dialysate. Waste products in the blood flow from the peritoneum into the dialysate. The dialysate is then drained from the abdomen.

There are two forms of peritoneal dialysis: continuous ambulatory peritoneal dialysis, where the abdomen is filled and drained several times during the day, and continuous cycler-assisted peritoneal dialysis, which uses a machine to cycle the fluid in and out of the abdomen at night while the person sleeps.

The most common side effects of peritoneal dialysis are infections in the abdominal cavity or in the area where the tube was implanted. Other side effects may include weight gain and hernias. A hernia is when the intestine pushes through a weak spot or tear in the lower abdominal wall.

Kidney disease normally does not go away once it’s diagnosed. The best way to maintain kidney health is to adopt a lifestyle with health-promoting benefits and follow your doctor’s advice. Kidney disease can get worse over time. It may even lead to kidney failure. Kidney failure can be life threatening if left untreated.

Kidney failure occurs when your kidneys are barely working or not working at all. Dialysis is an artificial process to manage the function of the kidneys. Dialysis involves the use of a machine to filter waste from your blood. In some cases, your doctor may recommend a kidney transplant.

Some non-modifiable risk factors for kidney disease — such as age or family history — cannot be controlled. Also, you cannot control ethnicity, which research shows can be an indicator that you’re at higher risk of developing kidney disease.

However, there are measures you can take to help prevent kidney disease:

  • drink plenty of water
  • manage your blood sugar if you have diabetes
  • manage your blood pressure
  • reduce salt intake
  • quit smoking if you smoke

Be careful with over-the-counter drugs

You should always follow the dosage instructions for over-the-counter medications. Taking too much aspirin (Bayer) or ibuprofen (Advil, Motrin) can cause kidney damage. Call your doctor if the normal doses of these medications are not managing your pain effectively.

Get tested

Ask your doctor about getting a blood test for kidney problems. Kidney problems generally don’t cause symptoms until they’re more advanced. A basic metabolic panel (BMP) is a standard blood test that can be done as part of a routine medical exam.

It checks your blood for creatinine or urea. These are chemicals that leak into the blood when the kidneys are not working properly. A BMP can detect kidney problems early, which is when they’re easier to treat.

You should be tested annually if you have:

  • diabetes
  • heart disease
  • high blood pressure

Limit certain foods

Different chemicals in your food can contribute to certain types of kidney stones. These include:

  • excessive sodium
  • animal protein, such as beef and chicken
  • citric acid, found in citrus fruits such as oranges, lemons, and grapefruits
  • oxalate, a chemical found in beets, spinach, sweet potatoes, and chocolate

Ask about calcium

Talk with your doctor before taking a calcium supplement. Some calcium supplements have been linked to an increased risk of kidney stones.