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Research into the efficacy of cannabidiol (CBD), a compound found in the cannabis plant, is still preliminary. But increasingly, people are turning to CBD to address any number of issues, including anxiety, chronic pain, nausea, and even neuropathy.

Unlike tetrahydrocannabinol (THC), the other well-known active compound in cannabis, CBD has no intoxicating effect. That means you won’t experience the “head high” associated with THC. Instead, you may benefit from its therapeutic properties.

If you’re exploring CBD as an option for managing symptoms of neuropathy, here’s what to understand about the early research and the products worth considering.

Neuropathy is a disorder stemming from malfunctioning peripheral nerves. It can be caused by a number of conditions, including diabetes, systemic illness, or infection.

Symptoms of neuropathy include:

There’s limited research about the role of CBD in treating neuropathy, but there is some evidence that it may help.

One small study of 29 people looked at the effects of topical CBD oil for relief and found significant improvement in pain and troublesome sensations.

A study from 2018 shows that medical cannabis consumed through vaporization or sublingually may also help symptoms of neuropathy. However, it’s important to note that the cannabis used had different THC concentrations.

Additionally, an animal study from 2017 found that CBD may help prevent chemotherapy‐induced peripheral neuropathy. Combining THC and CBD seemed to enhance the effects.

Plus, there’s anecdotal evidence, with people who have neuropathy claiming that CBD helps their symptoms.

Still, it’s important to understand that CBD Isn’t a cure-all for symptoms of neuropathy and more studies are needed to definitively declare that it’s an effective treatment.

According to the World Health Organization (WHO), CBD has a good safety profile. But there’s still a lot we don’t know about it. For that reason, it’s important to speak with your doctor before trying CBD for neuropathy. That’s especially important if your neuropathy is the result of a condition like cancer or diabetes or if you’re currently taking medications or supplements.

CBD may interact with some medications and supplements. People who are pregnant or under the age of 18 shouldn’t take CBD.

While CBD is generally well-tolerated, research shows that there can be side effects. These include:

  • changes in weight or appetite
  • fatigue
  • diarrhea

If you’re still interested in trying CBD for neuropathy and have gotten the OK from your doctor, be sure to do your research. Not all products are created equal.

Keep reading for a few we recommend.

We chose these products based on criteria we think are good indicators of safety, quality, and transparency. Each product in this article:

  • is made by a company that provides proof of third-party testing by an ISO 17025-compliant lab
  • is made with U.S.-grown hemp
  • contains no more than 0.3 percent THC, according to the certificate of analysis (COA)
  • passes tests for pesticides, heavy metals, and molds, according to the COA

As a part of our selection process, we also considered:

  • the company’s certifications and manufacturing processes
  • product potency
  • overall ingredients
  • indicators of user trust and brand reputation, such as:
    • customer reviews
    • whether the company has been subject to an FDA warning letter
    • whether the company makes any unsupported health claims

Where available, we’ve included special discount codes for our readers.

Pricing guide

  • $ = under $50
  • $$ = $50–$150
  • $$$ = over $150

Best full-spectrum CBD oil for neuropathy

CBDistillery Relief + Relax CBD Oil

  • Price: $$$
  • CBD type: full-spectrum
  • CBD potency: 5000 milligram (mg) per 30-milliliter (mL) bottle
  • COA: available on product page

This CBD oil is made with just two ingredients — fractionated coconut oil and full-spectrum hemp extract. Full-spectrum means it includes all of the beneficial compounds of the plant, including terpenes, flavonoids, and other cannabinoids.

At 5,000 milligram per bottle, it’s CBDistillery‘s most potent product and its best value, averaging out to $8 per serving. It’s also very highly reviewed.

This is a good option for people who are ready for a stronger dose of CBD.

Use code “healthline” for 15% off sitewide.

Best CBD isolate oil for neuropathy

Medterra CBD Tincture

  • Price: $–$$
  • CBD type: isolate
  • CBD potency: 500, 1000, 3000 mg per 30-mL bottle
  • COA: available on product page

CBD tinctures are Medterra’s most popular product. This oil is made with a blend of MCT oil and organically-grown CBD, with no other cannabinoids. It’s available in three potencies.

Note that this oil is unflavored, so expect an earthy taste.

Thousands of reviewers give Medterra’s CBD oil high marks for its great price point, clean taste, and efficacy.

Use code “health15” for 15% off.

Best CBD lotion for neuropathy

Cornbread Hemp CBD Lotion + Menthol

  • Price: $
  • CBD type: full-spectrum
  • CBD potency: 500 mg per 2-oz container
  • COA: available on product page

Cornbread Hemp has made a name for itself with its full-spectrum, flower-only CBD products, and this topical is no exception. It’s blended with organic menthol, lemongrass, and eucalyptus for a cooling, soothing sensation. It also absorbs quickly, with no oily residue.

Reviewers enjoy the therapeutic fragrance, quick onset, and longevity.

Use code “HEALTHLINE” for 25% off your first order.

There are a number of ways you can use CBD, depending on the product type.

If you’re using a CBD oil, taking it sublingually (or beneath the tongue) means you’ll feel the effects faster.

Topical CBD products are applied directly to the skin for on-the-spot relief.

In general, it’s a good idea to start with a low dose and slowly up your intake over time after assessing how you feel. Check manufacturer guidelines for a dosage starting point, but keep in mind that there are a lot of variables that will affect CBD dosing, including your body weight and individual body chemistry and the potency of your product.

It’s easy to find CBD products just about everywhere these days. But that doesn’t mean they’re all safe or effective. Ultimately, it’s up to you, as the consumer, to research your options before buying any CBD products. Here are a few tips:

  • Check for COAs from a third-party lab to confirm the quality of a specific product. This will give you information on whether the product contains what the label says it does. Make a point of reviewing cannabinoid potency, and whether the product passed tests for contaminants like molds and heavy metals.
  • Check for FDA warning letters or lawsuits. If a company has received a letter from the FDA for unverified health claims, or it’s been involved in a lawsuit, you can find out quickly with a simple online search. Reputable brands also include an FDA disclosure on their websites noting that their products aren’t intended to diagnose, treat, cure, or prevent disease.
  • Check the company’s reputation and customer reviews. This will give you an idea of what real customers think of a company and its products, so look for feedback on third-party review sites.

Treatments for neuropathy depend on the underlying disorder, but in many cases, a combination of treatments is most effective.

Medications, both over the counter and prescription, can be useful for controlling pain. Medical treatments, including blood transfusions and transcutaneous electronic nerve stimulation, are another option.

If neuropathy affects your feet, legs, hands, or arms, ergonomic splints and cases may be helpful.

Self-care can be another avenue worth exploring. Many people find relief from their symptoms with meditation, yoga, and moderate exercise, and by cutting back on alcohol and quitting cigarettes if you smoke. Both alcohol and tobacco aggravate nerve pain.

Other treatments like chiropractic care, acupuncture, and massage can also offer relief.

While research about how useful CBD is in treating symptoms of neuropathy is still limited, there is some evidence that it helps. If you’re considering CBD for neuropathy, speak with your doctor first. Then explore CBD oils and topical products to see how they work for you.

Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.


Jessica Timmons has been working as a freelance writer since 2007, covering everything from pregnancy and parenting to cannabis, chiropractic, stand-up paddling, fitness, martial arts, home decor, and much more. Her work has appeared in mindbodygreen, Pregnancy & Newborn, Modern Parents Messy Kids, and Coffee + Crumbs. See what she’s up to now at jessicatimmons.com.