During iontophoresis, a medical device uses mild electrical currents to deliver medication across biological membranes, often while your affected body part is submerged in water.

Iontophoresis is most commonly used to treat hyperhidrosis disorder, a condition that results in persistent and excessive sweating.

The currents are often delivered to the hands, feet, or armpits to block your sweat glands temporarily. Some feel a slight tingling sensation during the procedure, but the electrical current isn’t strong enough to shock you.

This sweating may occur in certain situations, such as during warm weather or physical activity, or without any trigger at all. It can also be caused by medical conditions, such as hyperthyroidism or menopause.

Aside from treating hyperhidrosis, iontophoresis may also be used to treat sports injuries by delivering anti-inflammatory medications directly into the skin.

Everyone sweats, but some people sweat more than others. People who frequently experience excessive or constant sweating for no apparent reason may have a condition called hyperhidrosis disorder.

Iontophoresis is one type of treatment that can be used to relieve symptoms of this condition. People with hyperhidrosis may undergo several iontophoresis sessions per week, each lasting about 20 to 40 minutes.

Doctors aren’t exactly sure why iontophoresis helps people with hyperhidrosis. However, it’s believed that the procedure blocks sweat from coming out of the sweat glands, temporarily stopping sweating.

Though iontophoresis is most often used to treat severe sweating, it may also be used to treat a variety of sports injuries.

Adding anti-inflammatory medicines to the water during iontophoresis can ease heel pain and other soft-tissue injuries.

The electrical current helps the skin easily absorb the medications. Iontophoresis can be especially effective in reducing swelling around the joints and relieving pain.

However, sprains or bursitis may respond well to this type of treatment.

Iontophoresis doesn’t require any special or advanced preparation. However, make sure to tell your doctor if you:

  • are pregnant
  • have epilepsy
  • have a heart condition
  • have a pacemaker or other metal implants, such as artificial joint replacements

You may not be able to undergo iontophoresis if you have any of the above medical conditions or devices. If this is the case, your doctor will recommend other options.

If you can undergo iontophoresis, it helps to apply a small amount of petroleum jelly to any cuts or scratches on your skin before beginning a session. This will protect open wounds from irritation during treatment.

If you’re performing an iontophoresis treatment at home, it’s also beneficial to add a teaspoon of baking soda to the water beforehand. This will regulate the pH level of the water and help ensure treatment is effective.

When being used as a treatment for hyperhidrosis, iontophoresis is often performed at a doctor’s office. However, you may be able to perform the treatments at home if you purchase the machine.

You’ll place the affected body part in a basin of water. Your healthcare provider will then turn on the machine and increase the current until you feel a slight tingling sensation on your skin. This shouldn’t cause any pain.

Most iontophoresis sessions for hyperhidrosis last 25 to 45 minutes. However, you’ll likely need more than one session to notice a change in your symptoms.

Some people with hyperhidrosis require treatments on a regular basis. Your doctor will schedule a series of sessions based on your symptoms. They may recommend that you buy a portable machine to use at home.

When being used as a treatment for a sports injury, iontophoresis is always performed at a doctor’s office. Your healthcare provider will add an anti-inflammatory medication to a basin of water, and you’ll place the injured area in the water.

Then, your doctor will apply a mild electrical current to the medicated water. You’ll feel a tingling sensation from the electrical current, but it shouldn’t be painful.

Most iontophoresis sessions for sports injuries last 10 to 15 minutes. Your doctor may order several sessions per week until your injury begins to heal.

Iontophoresis is a safe and painless procedure. Some people may experience side effects as a result of iontophoresis, but the effects usually aren’t serious.

The most common side effect is dryness of the skin. Blistering, peeling, and irritation might also occur on the skin.

However, these side effects can usually be treated by applying moisturizer to the skin after each session. An over-the-counter hydrocortisone cream can also help make you more comfortable.

Iontophoretic devices have been used to deliver a variety of anti-cancer agents.

These devices have shown promise in pre-clinical and clinical studies for retinoblastoma (a type of eye cancer), skin, bladder, and pancreatic cancers.

Chemotherapeutic agents to treat head and neck cancers can also be delivered using iontophoresis.

Local iontophoretic chemotherapy treatment leads to the reduction of drug side effects and is suggested for drugs that are too toxic when delivered systemically.

Anti-cancer drugs that can be administered via iontophoretic devices include cisplatin and 5-fluorouracil, which are used to treat skin cancer.

Other anti-cancer drugs, including imatinib mesylate and STAT3 siRNA complex can also be administered via iontophoresis.

Iontophoresis is generally effective in treating hyperhidrosis. People often undergo 20- to 40-minute treatment sessions several times per week until sweating decreases to a desirable level.

At that point, treatments are scheduled less frequently, usually about once per week.

Iontophoresis treatments must be done regularly and before sweating increases to maintain results.

Ongoing iontophoresis treatments for sports injuries are only needed until an injury begins to heal.

Most people with sports injuries undergo a handful of 5- to 10-minute treatment sessions over the span of a week or two to promote healing.

After that point, physical therapy, rest, and proper nutrition will continue aiding the healing process.

In a study involving a patient with basal cell carcinoma, the effectiveness of the iontophoresis treatment was confirmed by biopsies, which revealed no evidence of basal cell carcinoma.