If you have graft-versus-host disease (GVHD) or a certain kind of cancer, your doctor may prescribe Jakafi for you. It’s a prescription drug used to treat the following conditions:

To learn more about these conditions and how the drug is used, see the “What is Jakafi used for?” section below.

Jakafi basics

Jakafi comes as a tablet you swallow. It belongs to a drug class called kinase inhibitors. (A drug class is a group of drugs that work in a similar way.)

The active ingredient in Jakafi is ruxolitinib. (An active ingredient is what makes a drug work.) It’s not available in a generic form.

Read on to learn more about Jakafi’s side effects, dosage, uses, and more.

Like most drugs, Jakafi may cause mild to serious side effects. Below are lists of some of the more common side effects this drug may cause. But they don’t include all possible side effects.

Keep in mind that side effects of a drug can depend on:

  • your age
  • other health conditions you have
  • other medications you take
  • the condition you’re taking the drug to treat

Your doctor or pharmacist can tell you more about the potential side effects of Jakafi. They can also suggest ways to help reduce them.

Mild side effects

Here’s a list of some of the mild side effects Jakafi can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read the drug’s prescribing information.

Mild side effects of Jakafi that have been reported include:

Mild side effects of many drugs may go away within a few days to a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.

* To learn more about this side effect, see the “Allergic reaction” section below.

Serious side effects

Serious side effects from Jakafi can occur, but they aren’t common. If you have serious side effects from this drug, call your doctor right away. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Serious side effects of Jakafi that have been reported include:

* This side effect wasn’t reported in Jakafi’s studies. But it has been reported with a different kinase inhibitor (the group of drugs Jakafi belongs to). To learn more about your risk of this side effect with Jakafi, talk with your doctor.
† To learn more about this side effect, see the “Allergic reaction” section just below.

Allergic reaction

Some people may have an allergic reaction to Jakafi. While allergic reaction wasn’t reported in the drug’s studies, it can still happen.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can make it hard to breathe.

Call your doctor right away if you have an allergic reaction to Jakafi. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Costs of prescription drugs can vary depending on many factors, including what your insurance plan covers and which pharmacy you use.

If you have questions about your price for Jakafi and how to pay for your prescription, talk with your doctor or pharmacist. You may also be eligible for a program called IncyteCARES that can help you find ways to save on Jakafi’s cost.

You can also check out this article to learn more about saving money on prescriptions.

Below are answers to some commonly asked questions about Jakafi.

How does Jakafi compare with the alternatives Inrebic and Hydrea?

Below are a few ways that Jakafi compares with fedratinib (Inrebic) and hydroxyurea (Hydrea).

Jakafi, Inrebic, and Hydrea are used to treat similar kinds of cancer. (For details about Jakafi’s uses, see the “What is Jakafi used for?” section below.)

Jakafi and Inrebic are used to treat myelofibrosis (a kind of bone marrow cancer). Both belong to a group of drugs called kinase inhibitors. They each work in a similar way to treat this condition.

Jakafi and Hydrea are used to treat polycythemia vera (a kind of blood cancer). While Jakafi is a kinase inhibitor, Hydrea is an antimetabolite drug. Each medication works in a different way to treat this condition.

To learn more about how Jakafi, Inrebic, and Hydrea compare, talk with your doctor.

How long can you take Jakafi?

How long you’ll take Jakafi depends on your condition and how well the drug works to treat it. If you and your doctor decide that Jakafi is safe and effective for your condition, you’ll likely take it long term.

But if your condition hasn’t eased after 6 months of Jakafi treatment, your doctor may have you stop the drug. In this case, they may recommend a different treatment option for your condition.

Your doctor can advise you on how long you should expect to take Jakafi.

Does Jakafi cause hair loss or weight gain?

Jakafi isn’t known to cause alopecia (hair loss), but it may cause weight gain.

Hair loss wasn’t reported as a side effect in studies of Jakafi. But graft-versus-host disease (GVHD), which Jakafi is used to treat, may cause hair loss. (For details about the drug’s uses, see the “What is Jakafi used for?” section below.)

If you’re taking Jakafi for GVHD, you may notice hair loss. But this is likely to be caused by the condition instead of Jakafi.

Jakafi is known to cause weight gain. But this side effect was less commonly reported than others in studies of the drug.

If you have other questions about hair loss, weight gain, and Jakafi, talk with your doctor.

Can I develop long-term side effects from taking Jakafi?

Yes. Although rare, it’s possible to develop long-term side effects from taking Jakafi. Most side effects of this drug are temporary and only last a few days to weeks. And many of them will go away soon after you start or stop the drug.

But in rare cases, Jakafi may cause serious side effects that lead to long-term problems. Examples include:

It’s important to remember that the length of time Jakafi’s side effects last will differ from person to person. If you have more questions about Jakafi and its long-term side effects, talk with your doctor.

* These side effects weren’t reported in studies of Jakafi. But they have been reported with a different kinase inhibitor (the group of drugs Jakafi belongs to). To learn more about your risk of these side effects with Jakafi, talk with your doctor.

Does Jakafi cause specific side effects in people taking it to treat graft-versus-host disease (GVHD)?

It’s possible. In studies of Jakafi, certain side effects were only reported when the drug was used to treat GVHD. These side effects weren’t reported when the drug was used to treat polycythemia vera or myelofibrosis. (For details about these uses, see the “What is Jakafi used for?” section below.)

Below are examples of specific Jakafi side effects that may occur in people with GVHD:

If you have questions about what to expect with Jakafi treatment for GVHD, talk with your doctor.

Your doctor will recommend the dosage of Jakafi that’s right for you. Below are commonly used dosages, but always take the dosage your doctor prescribes.

Form and strengths

Jakafi comes as a tablet that you swallow. It’s available in several strengths:

  • 5 milligrams (mg)
  • 10 mg
  • 15 mg
  • 20 mg
  • 25 mg

Recommended dosages

Your doctor will likely start you on a low dosage of Jakafi. They’ll adjust it over time until you reach a dosage that treats your condition without causing bothersome side effects.

Your Jakafi dosage will be based on several factors, including:

  • your age
  • the severity of the condition you’re taking it to treat
  • any side effects you may have
  • other medical conditions you have, such as kidney or liver problems

Jakafi is used to treat graft-versus-host disease (GVHD), polycythemia vera, and myelofibrosis. For each of these conditions, you’ll likely take Jakafi twice daily.

For details about Jakafi’s dosage, see this article.

Questions about Jakafi’s dosing

Below are some common questions about Jakafi’s dosing.

  • What if I miss a dose of Jakafi? If you miss a dose of Jakafi, you can skip it. Then you can take your next dose at its usual time. Do not take any extra doses of Jakafi to make up for a missed dose. Doing so can increase your risk of side effects from the drug.
  • Will I need to take Jakafi long term? Whether you’ll take Jakafi long term depends on the condition you’re taking it for and how well the drug works to treat it. For details, see “How long can you take Jakafi?” in “What are some frequently asked questions about Jakafi?” above.
  • How long does Jakafi take to work? Jakafi starts working right away to treat your condition, but you may not notice that it is. Your doctor may order certain tests while you’re taking Jakafi to confirm it’s effectively treating your condition.

If you have graft-versus-host disease (GVHD) or a certain kind of cancer, your doctor may prescribe Jakafi for you. Keep reading to learn about the conditions Jakafi is used to treat.

GVHD

Jakafi is used to treat acute and chronic GVHD in adults and children ages 12 years and older.

GVHD is a condition that can occur after a bone marrow transplant (also called a stem cell transplant). With GVHD, donated stem cells attack healthy cells in your body.

Acute GVHD

GVHD is considered “acute” when it occurs within 3 months of a bone marrow transplant. Symptoms of this condition include:

Jakafi is used when acute GVHD has not eased after treatment with corticosteroids. Examples of corticosteroids include:

Chronic GVHD

GVHD is considered “chronic” when it occurs between 3 months and 1 year of a bone marrow transplant. Symptoms of chronic GVHD include:

Jakafi is used when chronic GVHD has not eased after treatment with one or two other therapies. Examples of these treatments include:

Polycythemia vera

Jakafi is used to treat polycythemia vera (PV) in certain adults. PV is a kind of blood cancer that causes your body to make too many red blood cells. PV can lead to problems such as an enlarged spleen and blood clots.

Symptoms of this condition include:

  • discolored skin
  • bleeding or bruising more easily than usual
  • fatigue (low energy)

Jakafi can be used when PV has not eased after treatment with hydroxyurea (Hydrea, Droxia). Or it may be used when hydroxyurea caused side effects that were too severe or bothersome to keep taking it.

Myelofibrosis

Jakafi is used to treat specific kinds of myelofibrosis in certain adults. Myelofibrosis is a kind of bone marrow cancer. It keeps your body from making healthy blood cells.

Myelofibrosis can lead to problems such as low red blood cell levels and an enlarged spleen. Symptoms of this condition include:

Jakafi can be used for the following kinds of myelofibrosis:

Stopping Jakafi should not cause withdrawal syndrome or withdrawal symptoms. Withdrawal syndrome refers to side effects that can happen when you stop taking a drug your body is used to having.

But stopping Jakafi may cause symptoms of the condition you were taking the drug to treat to return within a few weeks. For specific symptoms, see the “What is Jakafi used for?” section above.

For this reason, you should not stop taking Jakafi without first talking with your doctor. If they determine it’s safe, they may slowly lower your dosage over time. This will help reduce the risk of symptoms of your condition returning. (For details about Jakafi’s dosage, see this article.)

If you have questions about the side effects of stopping Jakafi, talk with your doctor.

Before taking Jakafi, it’s important to talk with your doctor. Tell them about any medical conditions you have, your overall health, and any other drugs you take. These and other factors are described in more detail below.

Interactions

Taking a medication with certain vaccines, foods, and other things can affect how the drug works. These effects are called interactions.

Before taking Jakafi, be sure to tell your doctor about all drugs you take, including prescription and over-the-counter kinds. Also, describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Jakafi.

For information about drug-condition interactions, see the “Warnings” section below.

Interactions with drugs or supplements

Jakafi can interact with several kinds of drugs. These include:

This list does not contain all kinds of drugs that may interact with Jakafi. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with this drug.

Other interactions

In addition to the drugs listed above, you may need to avoid certain foods with Jakafi.

Specifically, it may be best to avoid grapefruit and grapefruit juice while taking this drug. Grapefruit can prevent your body from breaking down Jakafi as it should. And this can increase the level of the drug in your body, increasing your risk of side effects.

To learn more about how grapefruit may interact with certain drugs, read this article. Talk with your doctor if you have questions about eating certain foods with Jakafi.

Warnings

Jakafi can sometimes cause harmful effects in people with certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether this drug is a good treatment option for you. Talk with your doctor about your health history before starting Jakafi. Factors to consider include those described below.

Kidney or liver problems. Before taking Jakafi, tell your doctor if you have a kidney or liver problem, such as kidney failure or liver failure. Your doctor may prescribe a lower than usual dosage of the drug for you. (For details about Jakafi’s dosage, see this article.)

Tuberculosis (TB) or hepatitis B. Before starting Jakafi treatment, tell your doctor if you’ve ever had TB or hepatitis B. Jakafi could reactivate the TB bacterium or hepatitis B virus in people who already have them in their bodies. (With reactivation, a bacterium or virus that you already have becomes active and causes symptoms.)

If you’ve had TB or hepatitis B, your doctor can tell you whether Jakafi is safe to take. They’ll watch for symptoms of TB and hepatitis B while you’re taking the drug. And they’ll recommend what you should do if the infection becomes active during treatment.

Allergic reaction. If you’ve had an allergic reaction to Jakafi or any of its ingredients, your doctor will likely not prescribe it for you. Ask them about other medications that might be better options.

Having specific factors that increase your risk of cardiac (heart-related) side effects. Jakafi may cause certain cardiac side effects, such as stroke and heart attack. Your risk of these side effects may be increased if you already have a high risk of heart problems.

Examples of factors that could increase your risk include:

If you have any of these factors, be sure to tell your doctor before starting Jakafi. They’ll advise you on whether it’s safe to take this drug.

Jakafi and alcohol

It should be safe to drink alcohol during treatment with Jakafi. If you have questions about consuming alcohol while taking this drug, talk with your doctor or pharmacist.

Pregnancy and breastfeeding

It’s not known whether Jakafi is safe to take while pregnant or breastfeeding. If you have questions about taking this drug during pregnancy or while breastfeeding, talk with your doctor.

Your doctor will explain how you should take Jakafi, including how much to take and how often. Be sure to follow your doctor’s instructions.

Taking Jakafi

Jakafi comes as a tablet that you swallow.

Accessible medication containers and labels

Certain pharmacies may provide medication labels that:

  • have large print
  • use braille
  • contain a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesn’t.

Also, if you’re having trouble opening your medication bottles, let your pharmacist know. They may be able to put Jakafi in an easy-open container. They may also recommend tools to help make it simpler to open the drug’s container.

Questions about taking Jakafi

Below are some common questions about taking Jakafi.

  • Can Jakafi be chewed, crushed, or cut in half? Jakafi’s drugmaker has not stated whether the tablets can be chewed, crushed, or cut in half. Because of this, it’s best to always swallow the tablets whole. If you have trouble swallowing tablets, check out this article or talk with your doctor or pharmacist.
  • Should I take Jakafi with food? You can take Jakafi with food or without it.
  • Is there a best time of day to take Jakafi? No, you can take the drug any time of day. But try to take your doses at about the same time each day. This can help keep a steady level of the drug in your body, which helps it work effectively.

Do not take more Jakafi than your doctor prescribes, as this can lead to serious side effects.

Symptoms of overdose

Symptoms caused by an overdose can include low levels of specific blood cells, including:

What to do in case you take too much Jakafi

Call your doctor if you think you’ve taken too much Jakafi. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 or your local emergency number or go to the nearest emergency room.

If you have questions about taking Jakafi, talk with your doctor or pharmacist. Questions you may want to ask include:

  • Will Jakafi cure my condition?
  • Will any of the other drugs I take interact with Jakafi?
  • How is Jakafi different from other drugs used to treat my condition?

To learn more about Jakafi, see these articles:

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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