If you’re considering treatment for hepatitis C, your doctor may recommend Epclusa.
It’s a prescription drug that’s used in adults and some children to treat hepatitis C, which is caused by hepatitis C virus. To learn more about hepatitis C and how Epclusa is used for it, see the “What is Epclusa used for?” section below.
Epclusa is an antiviral medication that contains two active drugs: sofosbuvir and velpatasvir. A combination drug made with sofosbuvir and velpatasvir is also available in a generic form.
Epclusa comes as tablets that you’ll swallow.
Read on to learn more about Epclusa’s side effects, uses, and more.
Like most drugs, Epclusa may cause mild or serious side effects. The lists below describe some of the more common side effects that Epclusa may cause. These lists don’t include all possible side effects.
Your doctor or pharmacist can tell you more about the potential side effects of Epclusa. They can also suggest ways to help reduce side effects.
Mild side effects
Here’s a short list of some of the mild side effects that Epclusa can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Epclusa’s important facts.
Mild side effects reported with the use of Epclusa include:
- fatigue (lack of energy)
- trouble sleeping
Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.
* This side effect was more common when people took another medication, ribavirin, along with Epclusa.
Serious side effects
Serious side effects from Epclusa can occur, but they aren’t common. If you have serious side effects from Epclusa, call your doctor right away. However, if you think you’re having a medical emergency, you should call 911 or your local emergency number.
Serious side effects reported with Epclusa use include:
- boxed warning: reactivation of hepatitis B*
- allergic reaction*
* For more information on this side effect, see the “Side effect focus” section below.
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Side effect focus
Learn more about some of the side effects Epclusa may cause.
With reactivation, the infection flares up and causes symptoms. In studies, some people with hepatitis B developed serious symptoms of hepatitis B reactivation. These included liver failure and, in some cases, death.
What might help
Before you start taking Epclusa, your doctor will order blood tests to see if you have hepatitis B or have had it in the past. If you have hepatitis B, your doctor will likely prescribe antivirals. And your doctor may wait until your hepatitis B is resolved before having you start Epclusa treatment.
While you’re taking Epclusa, your doctor will continue to monitor blood tests. And they’ll check you for signs and symptoms of hepatitis B. After you finish treatment with Epclusa, your doctor will continue to check you for hepatitis B for a while.
If you get hepatitis B or have hepatitis B reactivation while you’re taking Epclusa, you’ll need to start treatment for hepatitis B. Don’t stop taking Epclusa without first talking with your doctor.
Long-term side effects of Epclusa
Long-term side effects of Epclusa haven’t been reported. But some people have cirrhosis (scarring in the liver) that’s due to hepatitis C, which Epclusa is used to treat.
And if you have cirrhosis, you may have some long-lasting symptoms of the condition. These can include:
- feeling tired, weak, or confused
- poor appetite
- weight loss without trying
- nausea and vomiting
- liver pain, which may be mild pain in the upper right side of your belly
- bruising or bleeding more easily than usual
- swelling or bloating from fluid buildup in your belly
- itchy skin
- dark urine
- jaundice (yellowing of your skin or the whites of your eyes)
What might help
During and after treatment with Epclusa, tell your doctor right away if you have any symptoms of cirrhosis.
Keep in mind that liver damage, including that caused by cirrhosis, is permanent. So your doctor may suggest tips to prevent further worsening of your liver health. These tips may include:
- avoiding alcohol
- getting a hepatitis B vaccine
- eating healthy foods
- managing a body weight that’s healthy for you
Side effects after Epclusa treatment
People haven’t reported side effects after finishing with Epclusa treatment.
However, hepatitis C, which Epclusa is used to treat, is a long-lasting condition that gets worse over time. The risk of hepatitis C getting worse is increased if you have:
- alcohol use disorder
- cirrhosis (scarring in the liver)
- hepatitis B
Epclusa lowers the amount of hepatitis C virus in your body. If your levels are low enough to not be seen on a blood test, certain risks become lower. These risks include cirrhosis and death from liver damage.
When you stop taking Epclusa for hepatitis C, your condition may worsen. And this could cause symptoms of hepatitis C, which may include:
- a general feeling of illness
- liver pain
- dark urine
What might help
After you finish treatment with Epclusa, your doctor will order a blood test to check if Epclusa was successful in clearing hepatitis C virus from your body. If the blood test shows that Epclusa didn’t fully clear hepatitis C from your body, you and your doctor will determine what steps should be taken next.
If you have any symptoms of hepatitis C after finishing your treatment with Epclusa, talk with your doctor right away. They can order to tests to see if your hepatitis C has worsened.
Some people may have an allergic reaction to Epclusa. While allergic reaction wasn’t reported in clinical studies of Epclusa, it can still happen.
Symptoms of a mild allergic reaction can include:
- skin rash
- flushing (warmth, swelling, or redness in your skin)
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.
Call your doctor right away if you have an allergic reaction to Epclusa. But if you think you’re having a medical emergency, call 911 or your local emergency number.
Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. To find current prices for Epclusa in your area, visit GoodRx.com.
If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Epclusa manufacturer’s website to see if they have support options.
Some important things to discuss with your doctor when considering Epclusa include your overall health and any medical conditions you may have.
Tell your doctor if you’re taking any prescription or over-the-counter medications. This is important because many drugs interact with Epclusa.
These and other considerations to discuss with your doctor are described below.
Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions.
Before taking Epclusa, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Epclusa.
Interactions with drugs or supplements
Epclusa can interact with several types of drugs, including:
- the antibiotics rifampin, rifabutin (Mycobutin), and rifapentine (Priftin)
- the HIV medications efavirenz (Sustiva), tenofovir (Viread), tipranavir (Aptivus), and ritonavir (Norvir)
- the cancer drug topotecan (Hycamtin)
- the herb St. John’s wort
- the cholesterol medications rosuvastatin (Crestor) and atorvastatin (Lipitor)
- the heart drugs amiodarone (Pacerone) and digoxin (Lanoxin)
- the seizure drugs carbamazepine (Tegretol), phenytoin (Dilantin), and phenobarbital
- stomach-acid-reducing drugs, such as famotidine (Pepcid), aluminum and magnesium hydroxide, and omeprazole (Prilosec)
This list does not contain all types of drugs that may interact with Epclusa. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of Epclusa.
You can take Epclusa with or without food. But you may need to avoid certain foods with Epclusa. Food interactions occur when a food interferes with how a medication works.
For instance, grapefruit and grapefruit juice contain chemicals that can interact with Epclusa. If you eat grapefruit or drink its juice while taking Epclusa, the drug may not work as well as usual.
Before taking Epclusa, talk with your doctor or pharmacist about possible food interactions.
Epclusa has a boxed warning. This is a serious warning from the Food and Drug Administration (FDA) about drug effects that may be dangerous.
Boxed warning: Reactivation of hepatitis B infection
Epclusa has a boxed warning about reactivation of hepatitis B infection. A
If you have hepatitis C and you have hepatitis B or have had it in the past, Epclusa can cause reactivation of hepatitis B. With reactivation, the infection flares up and causes symptoms. In studies, some people with hepatitis B developed serious symptoms of hepatitis B reactivation. These included liver failure and, in some cases, death.
Before you start treatment with Epclusa, your doctor will order blood tests to see if you have hepatitis B or have had it in the past.
For more information, see the “What are Epclusa’s side effects?” section below.
Epclusa may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you take Epclusa. Factors to consider include those in the list below.
- Allergic reaction. If you’ve had an allergic reaction to Epclusa or any of its ingredients, you shouldn’t take Epclusa. Ask your doctor what other medications are better options for you.
- Liver problems other than hepatitis C infection. If you have severe liver disease, talk with your doctor. They may need to prescribe another medication in addition to Epclusa to treat your hepatitis C.
- History of a liver transplant. Epclusa has been studied in people who’ve had a liver transplant and certain types of hepatitis C virus. But the drug hasn’t been studied in people with other types of hepatitis C virus. If you’ve had a liver transplant, talk with your doctor about whether Epclusa is right for you
- Past kidney disease. Recent studies in people with severe kidney disease, including people having dialysis treatment, found Epclusa to be safe. And the drug worked just as well as usual. But it’s still important to tell your doctor about any kidney disease you may have. This is because a drug called ribavirin shouldn’t be used in people with a certain level of kidney disease. And ribavirin is sometimes prescribed together with Epclusa to treat hepatitis C infection.
- HIV infection. Certain HIV medications shouldn’t be used with Epclusa. Some medications used to treat HIV can harm your liver. This could affect how well Epclusa works for you. Be sure to tell your doctor if you have HIV, and about all medications you take, before you start taking Epclusa.
Use with alcohol
Epclusa isn’t known to interact with alcohol. But keep in mind that hepatitis C, which Epclusa is used to treat, gets worse over time. And drinking alcohol may worsen hepatitis C more quickly. So your doctor may recommend that you avoid drinking alcohol.
Before starting Epclusa, ask your doctor or pharmacist if it’s safe for you to drink alcohol.
Pregnancy and breastfeeding
It’s not known whether Epclusa is harmful if used during pregnancy. Before starting Epclusa, be sure to tell your doctor if you’re pregnant or considering pregnancy.
Sometimes, Epclusa is prescribed together with ribavirin (Rebetol), another hepatitis C medication. And taking ribavirin during pregnancy is unsafe.
If you or your partner are pregnant or considering pregnancy, talk with your doctor before taking ribavirin. Tell your doctor right away if you or your partner becomes pregnant during or after Epclusa treatment.
It’s not known whether Epclusa passes into breast milk. If you’re breastfeeding, talk with your doctor about whether it’s safe for you to take Epclusa.
Your doctor will explain how you should take Epclusa. They’ll also explain how much to take and how often. Be sure to follow your doctor’s instructions. Below are commonly used dosages, but always take the dosage your doctor prescribes.
Epclusa comes as tablets that each contain two active drugs. And it’s available in two strengths:
- 400 milligrams (mg) of sofosbuvir and 100 mg of velpatasvir
- 200 mg of sofosbuvir and 50 mg of velpatasvir
Your doctor will recommend the dose of Epclusa that’s right for you. For children ages 6 years and older, doctors will prescribe Epclusa based on the child’s body weight.
You’ll take Epclusa once per day.
Your doctor will recommend a dosing schedule of Epclusa that’s right for you. In general, you’ll take Epclusa for 12 weeks.
Taking Epclusa with other drugs
If you have symptoms of cirrhosis (scarring of the liver), your doctor will prescribe Epclusa together with a drug called ribavirin (Rebetol).
Like Epclusa, ribavirin is used for hepatitis C. But unlike Epclusa, which you can take with or without food, ribavirin must be taken with food.
You doctor will prescribe the appropriate dose of ribavirin for you based on your body weight.
Questions about taking Epclusa
Below are answers to some questions you may have about taking Epclusa.
- What if I miss a dose of Epclusa? If you miss a dose of Epclusa, take it as soon as you remember. Try to avoid missing or skipping any doses. Missing a dose lowers the amount of Epclusa in your body. It also affects how well the drug works against hepatitis C virus. You shouldn’t double your dose if you forget to take a dose of Epclusa. If you’re unsure when to take a missed dose of Epclusa, talk with your doctor or pharmacist.
- Will I need to use Epclusa long term? Your doctor will prescribe Epclusa for 12 weeks to treat hepatitis C.
- Can Epclusa be chewed, crushed, or split? It’s unknown whether you can chew, crush, or split Epclusa. If you’re having trouble swallowing Epclusa, talk with your doctor or pharmacist. They can give you tips on how to take Epclusa safely.
- Should I take Epclusa with food? You can take Epclusa with or without food. If you have nausea when taking Epclusa, try taking it with food.
- How long does Epclusa take to work? Epclusa starts working quickly in your body to stop hepatitis C virus from making more of itself. But not everyone may have the same experience with Epclusa. Ask your doctor how long it should take for Epclusa to work for you. In studies, many people taking Epclusa had cleared hepatitis C after 12 weeks of treatment.
Questions for your doctor
You may have questions about Epclusa and your treatment plan. It’s important to discuss all your concerns with your doctor.
Here are a few tips that might help guide your discussion:
- Before your appointment, write down questions like:
- How will Epclusa affect my body, mood, or lifestyle?
- Bring someone with you to your appointment if doing so will help you feel more comfortable.
- If you don’t understand something related to your condition or treatment, ask your doctor to explain it to you.
Remember, your doctor and other healthcare providers are available to help you. And they want you to get the best care possible. So don’t be afraid to ask questions or offer feedback on your treatment.
Epclusa can be used in adults. It can also be used in children ages 6 years and older weighing at least 17 kilograms (about 37 pounds).
Epclusa may be prescribed for people with or without
If you don’t have cirrhosis, or if you have compensated cirrhosis, your doctor may prescribe Epclusa by itself. But if you have decompensated cirrhosis, your doctor may prescribe Epclusa together with a medication called ribavirin (Rebetol).
Epclusa is an antiviral medication that targets the hepatitis C virus. This virus
Find answers to some commonly asked questions about Epclusa.
If I stop taking Epclusa, will I have withdrawal symptoms?
No, you won’t have withdrawal symptoms if you stop taking Epclusa. But you must take Epclusa for the entire 12 weeks that it’s prescribed for you.
Missing doses or stopping treatment before then can affect how well Epclusa works to treat hepatitis C. And if your hepatitis C isn’t treated like it should be, it could worsen and cause symptoms. For more information about this, see the “What are Epclusa’s side effects?” section above.
Does Epclusa cause weight loss?
No, Epclusa doesn’t affect your body weight. But weight loss can be a sign of infections, including hepatitis C. And keep in mind that Epclusa is used to treat hepatitis C.
You may also lose weight if you have nausea while you’re taking Epclusa. Talk with your doctor or pharmacist about ways to help reduce your nausea during Epclusa treatment.
If you’re concerned about your weight while you’re taking Epclusa, talk with your doctor.
Can I take ibuprofen with Epclusa?
Yes, you can likely take ibuprofen (Advil) with Epclusa. There isn’t a known interaction between ibuprofen and Epclusa.
Before taking ibuprofen, talk with your doctor or pharmacist about its safety. They can instruct you on how to safely take ibuprofen with Epclusa.
Both Epclusa and Harvoni contain two antiviral medications used to treat hepatitis C. They both contain sofosbuvir. But instead of velpatasvir, Harvoni contains a drug called ledipasvir. Both Epclusa and Harvoni work in the same way to treat hepatitis C.
Both Epclusa and Harvoni have boxed warnings for reactivation of hepatitis B in people who have both hepatitis C and hepatitis B. A
With reactivation, an infection flares up and causes symptoms. In clinical studies of Epclusa and Harvoni, some people with hepatitis B developed serious symptoms of hepatitis B reactivation. These included liver failure and, in some cases, death. For more information about this side effect, see the “What are Epclusa’s side effects?” section above.
Both Epclusa and Harvoni are used for certain types of hepatitis C virus, which causes hepatitis C. Epclusa can be used in people ages 6 years and older who weigh at least 17 kilograms (about 37 pounds). But Harvoni can be used in people ages 12 years and older or those who weight at least 35 kilograms (77 pounds).
Like Epclusa, Harvoni is taken for 12 weeks, but with two exceptions. Some adults and children must take Harvoni for 24 weeks. This includes people who either:
- already received treatment for hepatitis C, but their treatment didn’t work, or
- have compensated cirrhosis (scarring of the liver with no symptoms)
Don’t take more Epclusa than your doctor prescribes. Using more than this can lead to serious side effects. If you take too much Epclusa, your doctor may closely monitor you for signs and symptoms of overdose.
What to do in case you take too much Epclusa
Call your doctor if you think you’ve taken too much Epclusa. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use their online resource. However, if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
If you have questions about taking Epclusa, talk with your doctor or pharmacist. Your doctor can tell you about treatments other than Epclusa for hepatitis C. Here’s a list of articles you might find helpful:
- What Are the Newest Treatments for Hepatitis C?
- How Much Does Treatment for Hepatitis C Cost?
- Then and Now: The Evolution of Treatments for Hepatitis C
Some questions you may want to ask your doctor about Epclusa include:
- How should I store Epclusa?
- Do I need to take other medications with Epclusa to treat hepatitis C?
- Can I still take Epclusa if I tried other hepatitis C drugs in the past that didn’t work?
- What’s the maximum dose of ibuprofen I can take while taking Epclusa?
- How can I prevent nausea while taking Epclusa?
Are there certain foods I should not eat while taking Epclusa?Anonymous patient
There aren’t certain foods you should avoid eating while you’re taking Epclusa. To date, no foods have been found to affect how well the drug works or how safe it is.
If you have questions about eating specific foods while taking Epclusa, talk with your doctor or pharmacist.Alex Brewer, PharmD, MBAAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.