Tryptophan is an essential amino acid that serves several important purposes, like nitrogen balance in adults and growth in infants. It also creates niacin, which is essential in creating the neurotransmitter serotonin.
There are two types of tryptophan: L-tryptophan and D-tryptophan. The only difference between the two types is the orientation of the molecule.
You can get tryptophan through certain foods or a supplement in powder form.
Tryptophan can be found in some foods, especially those high in protein. Foods known to be high in tryptophan include:
- pumpkin and sesame seeds
- tofu and soy
Tryptophan can have plenty of health benefits, but the supplement can cause a number of unpleasant side effects in people.
The most common are gastrointestinal side effects, which include:
Other common side effects include:
More serious side effects, which warrant immediately stopping consumption, include:
There are a number of health benefits from the naturally-occurring tryptophan found in foods. Most of these health benefits come from the potential increase of niacin and thus serotonin. The benefits from more serotonin include:
While tryptophan consumed through food is typically safe, some people experience adverse effects from the supplement form.
According to the National Organization for Rare Disorders, tryptophan supplements were linked to over 1,500 reports of eosinophilia-myalgia syndrome (EMS) and 37 deaths in an epidemic in the late 1980s. This is a rare disorder that affects multiple organ systems within the body, including the skin, lungs, and muscles. It’s often sudden and progresses rapidly. It can be disabling and it can even cause death. Symptoms include:
- muscle pain or weakness
- skin rashes
- difficulty breathing
Tryptophan can help treat symptoms of some conditions, but it may raise your serotonin levels too much, especially if combined with medications like:
- tricyclic antidepressants (TCAs)
- MAO inhibitors (MAOIs)
- pain relievers like tramadol and meperidine
- triptan migraine medications
- cough syrup that contains dextromethorpan
If you’re taking selective serotonin reuptake inhibitors (SSRIs), you shouldn’t increase your tryptophan without talking to your doctor. The increased serotonin from the tryptophan can contradict the purpose of the SSRIs. Several common depression medications fall under this category, including:
More research is needed, but tryptophan supplements are regarded as possibly unsafe. Some organizations suggest not taking them altogether. They’re also unsafe for pregnant or breastfeeding women to take. Don’t take tryptophan if you’re pregnant, trying to become pregnant, or breastfeeding.
It’s also thought that tryptophan supplements may make liver or kidney disease worse due to its ties to EMS. Because of this, don’t take tryptophan supplements if you have preexisting kidney or liver problems.
Tryptophan is commonly used to treat insomnia and sleep disorders like sleep apnea, however, there’s not enough evidence to determine whether this is an effective use. More research needs to be done to see if tryptophan is safe to treat any of these conditions.
Tryptophan has been noted as possibly effective for helping to relieve premenstrual dysphoric disorder (PMDD). Some shows that tryptophan may be effective for smoking cessation, too.
While tryptophan supplements are available, they can be extremely dangerous for some people. Because of this, it’s better and much safer to obtain tryptophan through the foods that naturally contain it, like meat, fish, and cheese. Instead of tryptophan supplements, your doctor may recommend that you take 5-HTP supplements instead, which is tryptophan before it’s fully converted into serotonin.
If you do decide to take either supplement, talk to your doctor first to make sure that it’s safe for you.