GcMAF as a Cancer Treatment

Medically reviewed by Yamini Ranchod PhD, MS on November 8, 2017Written by Kiara Anthony on November 8, 2017

What is GcMAF?

GcMAF is a vitamin D-binding protein. It’s scientifically known as Gc protein-derived macrophage activating factor. It’s a protein that supports the immune system, and naturally found in the body. GcMAF activates macrophage cells, or the cells responsible for fighting off infection and disease.

GcMAF and cancer

GcMAF is a vitamin protein found naturally in the body. It activates the cells responsible for tissue repair and initiating an immune response against infection and inflammation, so it may have the potential to kill cancer cells.

The immune system’s job is to protect the body from germs and infection. However, if cancer forms in the body, these defensive cells and their functions can be blocked.

Cancer cells and tumors release a protein called nagalase. When released, it prevents immune system cells from functioning properly. GcMAF protein is then blocked from converting to a form that boosts immune response. If your immune system doesn’t work properly, you may not be able fight off infection and cancer cells.

GcMAF as an experimental cancer treatment

Because of GcMAF’s role in the immune system, one theory is that an externally developed form of this protein may have the potential to treat cancer. The theory is, by injecting external GcMAF protein into the body, the immune system can function better and fight off cancer cells.

This treatment method isn’t approved for medical use, and is highly experimental. A recent phase I clinical trial is examining a cancer immunotherapy developed from natural Gc protein. However, no study results have been posted. This is the first time this treatment is being examined using established research guidelines.

Previous research available from certain institutions on this treatment method has been questioned. In one case, the studies on GcMAF and cancer were retracted. In another case, the research group publishing the information also sells the protein supplements. Therefore, there’s a conflict of interest.

Side effects of GcMAF therapy

According to a 2002 article on GcMAF published in the Journal of the National Cancer Institute, mice and humans who received purified GcMAF didn’t experience “toxic or negative inflammatory” side effects.

What’s the outlook?

GcMAF therapy is still being researched as a possible effective treatment for cancer. However, it’s important to note that GcMAF supplementation isn’t approved for medical use for treating cancer or any other health conditions.

It’s not recommended that you abandon traditional cancer treatment options in favor of GcMAF therapy. The little data available on GcMAF therapy for cancer is questionable due to the integrity of the research. In some cases, the researchers worked for companies that made the drug. In other cases, the studies were published and later retracted.

Further research needs to be conducted. Until then, any beneficial role of GcMAF in cancer treatment is uncertain.

CMS Id: 136462