Zoryve (roflumilast) is a prescription drug that’s used to treat plaque psoriasis in adults and certain children. The drug comes as a topical cream that’s usually applied to the skin once per day.
The active ingredient in Zoryve is roflumilast. (An active ingredient is what makes a drug work.) Zoryve belongs to a group of drugs called phosphodiesterase-4 (PDE-4) inhibitors.
This article describes the dosage of Zoryve, as well as its strength and how to use it. To learn more about Zoryve, see this in-depth article.
This section describes the usual dosages of Zoryve. Keep reading to learn more.
What is Zoryve’s form?
Zoryve comes as a topical cream that you apply to your skin.
What strength does Zoryve come in?
Zoryve comes in one strength of 0.3%.
What’s the usual dosage of Zoryve for plaque psoriasis?
The typical Zoryve dosage for adults with plaque psoriasis is a thin layer applied to the affected area once per day.
What’s the dosage of Zoryve for children?
Zoryve is used to help treat plaque psoriasis in children ages 6 years and older.
The dosage used in children is the same as the dosage for adults. The drug is applied as a thin layer to the affected area of skin once per day.
For more information about Zoryve’s dosage for children, talk with your child’s doctor or a pharmacist.
Is Zoryve used long term?
Yes, Zoryve is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely use it long-term.
Zoryve comes as a topical cream that you apply to your skin. You should wash your hands after using Zoryve, except if it’s being used to treat plaque psoriasis on your hands.
For information on the expiration, storage, and disposal of Zoryve, talk with your doctor or pharmacist.
Accessible drug containers and labels
Some pharmacies provide medication labels that:
- have large print
- use braille
- feature a code you can scan with a smartphone to change the text to audio
Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.
If you miss a dose of Zoryve, apply the dose as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and apply your next dose at its usual time. If you’re not sure whether you should apply a missed dose, talk with your doctor or pharmacist.
If you need help remembering to use Zoryve on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.
Do not use more Zoryve than your doctor prescribes, as this can lead to harmful effects.
What to do in case you use too much Zoryve
Call your doctor right away if you think you’ve used too much Zoryve. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Below are answers to some commonly asked questions about Zoryve’s dosage.
Is Zoryve’s dosage similar to the dosages of Vtama or Humira?
These drugs are all used to treat plaque psoriasis. Zoryve and tapinarof (Vtama) are both topical creams applied once per day. Humira, on the other hand, is a liquid solution that’s given as an injection under your skin every other week.
The dose in milligrams for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.
To learn more about how these drugs compare, talk with your doctor.
How long does it take for Zoryve to start working?
Zoryve starts to work after your first dose. You may notice your plaque psoriasis symptoms begin to ease as early as 2 weeks after starting treatment. But in some people, it may take up to 8 weeks before you see a significant difference in your symptoms.
If you have other questions about what to expect from your Zoryve treatment, talk with your doctor.
The sections above describe the usual dosage provided by the manufacturer. If your doctor recommends Zoryve for you, they’ll prescribe the dosage that’s right for you.
Remember, you should not change your dosage of Zoryve without your doctor’s recommendation. Only use Zoryve exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.
Here are some examples of questions you may want to ask your doctor:
- Will you need to adjust my dosage of Zoryve if I take other medications?
- I use vitamins and herbal supplements, should my dosage for Zoryve be changed?
- Should I adjust my dosage of Zoryve if I eat grapefruit regularly?
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.