If you’re looking at treatment options for type 2 diabetes, your doctor might tell you about Trulicity (dulaglutide).

Trulicity is a prescription medication that’s used in adults with type 2 diabetes to:

  • Help lower blood sugar levels. Trulicity is typically used with a diet and exercise plan to improve blood sugar levels.
  • Lower the risk of major heart problems, such as heart attack, stroke, and death resulting from cardiovascular issues. This use is for people who have heart disease or are at risk for heart disease, in addition to having type 2 diabetes.

Trulicity comes as a liquid solution inside prefilled, single-dose pens. It contains the active drug dulaglutide and belongs to a class of drugs called glucagon-like peptide-1 agonists. (A class of drugs describes a group of medications that work in the same way.)

For information on the dosage of Trulicity, including its form, strengths, and how to use the drug, keep reading. To learn more about Trulicity, see this in-depth article.

Note: This article covers Trulicity’s typical dosages, which are provided by the drug’s manufacturer. But when using Trulicity, always take the dosage that your doctor prescribes.

Below is information about Trulicity’s form, strengths, and typical dosages.

What is Trulicity’s form?

Trulicity comes as a liquid solution inside disposable pens. You’ll receive Trulicity as a subcutaneous injection (an injection under your skin) once per week.

There is one dose per pen, and each pen delivers the entire dose in one injection. For each new dose, you’ll need a new pen.

What strengths does Trulicity come in?

Trulicity is available in four strengths:

  • 0.75 milligrams (mg) per 0.5 milliliters (mL) of liquid solution
  • 1.5 mg per 0.5 mL of liquid solution
  • 3 mg per 0.5 mL of liquid solution
  • 4.5 mg per 0.5 mL of liquid solution

What are the typical dosages of Trulicity?

The typical dosage range for Trulicity is 0.75 mg to 4.5 mg once per week. The usual starting dose is 0.75 mg. After you start using Trulicity, your doctor will monitor your blood sugar levels to see how the drug is working. If needed, they may suggest a dose increase to help with lowering your blood sugar levels.

The highest dose of Trulicity is 4.5 mg, given once per week.

Typically, your doctor will start you on a low dosage. Then they’ll adjust your dosage over time to reach the right amount for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for lowering blood sugar levels in adults with type 2 diabetes

Trulicity is prescribed to help lower blood sugar in adults with type 2 diabetes. The medication is used with a diet and exercise plan for this purpose.

The typical starting dosage of Trulicity for this use is 0.75 mg once per week. During treatment, your doctor will monitor your blood sugar levels. They may increase your dosage if needed to better manage your condition. The maximum Trulicity dosage to help lower blood sugar is 4.5 mg once per week.

The dosing guide below shows typical increases for Trulicity.

Factors affecting dosageTrulicity dosage
starting Trulicity treatment for high blood sugar0.75 mg once per week
if blood sugar needs to be lowered moreincrease to 1.5 mg once per week
if blood sugar is still too high after 4 weeks of the 1.5-mg doseincrease to 3 mg once per week
if blood sugar is still too high after 4 weeks of the 3-mg doseincrease to 4.5 mg once per week

Dosage for lowering the risk of major heart problems in adults with type 2 diabetes

Trulicity is also prescribed to lower the risk of major heart problems in adults with type 2 diabetes. This use is for people who have heart disease or are at risk for heart disease, in addition to having type 2 diabetes.

The dosage for this use is the same as it is for lowering blood sugar levels in people with type 2 diabetes. See the “Dosage for lowering blood sugar levels in adults with type 2 diabetes” section directly above for details.

Is Trulicity used long term?

Yes, Trulicity is typically used as a long-term treatment. If you and your doctor determine that Trulicity is safe and effective for you, it’s likely that you’ll use it long term.

You’ll use Trulicity once per week. It’s best to have your Trulicity injection on the same day every week.

If you miss a dose of Trulicity, and it’s at least 72 hours (3 days) before your next scheduled dose, take the missed dose.

If your next scheduled dose is within 72 hours, skip the dose you missed. Take your next scheduled dose when you normally would.

Do not take more than one dose in 72 hours. Using too much Trulicity too soon can increase your risk for side effects, like nausea or diarrhea. If you use other medications for diabetes and take too much Trulicity too soon, you could increase your risk for hypoglycemia (low blood sugar), which can be serious.

It’s possible to change the day of the week you take your Trulicity dose. But make sure there are at least 72 hours between your doses. Your doctor can help guide you on changing your injection to a different day.

It’s important to follow the dosing schedule your doctor prescribes for you. If you need help remembering to take your dose of Trulicity on time, try using a medication reminder. This can include setting an alarm, downloading a reminder app, or setting a timer on your phone. A kitchen timer can work, too.

If you have questions about what to do if you miss a dose of Trulicity, talk with your doctor or pharmacist.

Here are answers to a few common questions about Trulicity’s dosage.

Is Trulicity used for weight loss? If so, what’s the dosage?

No, Trulicity isn’t a weight-loss drug. But some people using Trulicity did report weight loss. This is because of how the drug works in the body. For more information on how Trulicity works, see this article.

If you have questions about managing your weight or using Trulicity, talk with your doctor.

Where can I find dosage instructions for Trulicity?

The manufacturer of Trulicity has step-by-step instructions and a video to help you learn how to use Trulicity correctly.

If you have questions about the correct way to use Trulicity, your doctor or pharmacist should also be able to help you.

How do the dosages of Trulicity and Ozempic compare?

The dosages of Trulicity and Ozempic vary depending on your individual treatment plan. (Ozempic is a drug that’s used to treat the same conditions as Trulicity.) Here’s some information on the forms of each drug and standard dosages.

Like Trulicity, Ozempic comes as a liquid solution inside a disposable pen. And each medication is given as a subcutaneous injection (an injection under the skin) once per week.

Trulicity comes in single-dose disposable pens. You need a new pen for each dose of Trulicity. Ozempic comes in multidose disposable pens. This means you use the same pen for more than one dose.

Trulicity’s starting dosage is 0.75 mg once per week. Your doctor may increase your weekly dose to a maximum of 4.5 mg if needed.

Ozempic’s starting dosage is 0.25 mg once per week. Your doctor may increase your weekly dose to a maximum of 1 mg if needed.

Keep in mind that the dosages of Trulicity or Ozempic vary depending on your individual treatment plan. If you have questions about the right dosage for you, talk with your doctor.

For details on Trulicity’s dosage, see “What is Trulicity’s dosage?” above. You can learn more about Ozempic’s dosage here. For additional information on how Trulicity compares with Ozempic, see this article.

The dosage of Trulicity you’re prescribed may depend on several factors. These include:

  • the type and severity of the condition you’re using Trulicity to treat
  • other medications you may be taking
  • any side effects you may have while using Trulicity

Trulicity is given as a subcutaneous injection (an injection under the skin) once per week. Your doctor or another healthcare professional can show you how to give yourself these injections.

You’ll inject Trulicity under the skin of your belly, upper arm, or thigh. You should rotate the injection site (change the location of your injection) every week. This helps prevent hard lumps or fatty deposits from forming in the area of the injection.

For more information about how to use Trulicity correctly, see these step-by-step instructions and this video. If you have questions about using Trulicity, you can also ask your doctor or pharmacist.

Don’t use more Trulicity than your doctor prescribes. Using more than this can lead to serious side effects.

Symptoms of overdose

Symptoms caused by an overdose can include:

What to do in case you use too much Trulicity

Call your doctor right away if you think you’ve used too much Trulicity. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use their online resource. However, if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The sections above describe the typical dosages provided by the drug manufacturer. If your doctor recommends Trulicity for you, they will prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Trulicity without your doctor’s approval. Only use Trulicity exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Would a different dosage affect my risk for side effects from Trulicity?
  • How will you tell if my current dosage of Trulicity isn’t working well enough for me?
  • I’d like to start taking a certain supplement. Will my dosage of Trulicity need to be adjusted?

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Q:

My doctor just started me on Trulicity treatment. Can you tell me about symptoms I should watch for to make sure my blood sugar isn’t getting too low?

Anonymous patient

A:

It’s possible to have hypoglycemia (low blood sugar) while taking Trulicity, including when you first start taking the medication.

Some symptoms of hypoglycemia to watch for include:

While taking Trulicity, you should also monitor your blood sugar according to your doctor’s instructions. If you notice symptoms of low blood sugar or your blood sugar measurements are low, contact your doctor. They may want to adjust the dosage of your diabetes medications, including Trulicity.

Alex Brewer, PharmD, MBAAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.