Tezspire (tezepelumab-ekko) is a prescription drug that’s used to treat severe asthma. It comes as a liquid solution that’s given by injection under the skin. Tezspire is given by you or a healthcare professional, usually once every 4 weeks.

Tezspire is used in combination with other medications.

The active ingredient in Tezspire is tezepelumab-ekko. (An active ingredient is what makes a drug work.) Tezspire belongs to a group of drugs called monoclonal antibodies.

Specifically, it’s a thymic stromal lymphopoietin blocker and human monoclonal antibody. Tezspire is a biologic drug, which means it’s made from living cells.

This article describes the dosage of Tezspire, as well as its strength and how it’s given. To learn more about Tezspire, see this in-depth article.

Note: Tezspire is not meant to treat sudden breathing problems such as an asthma attack. You should use your rescue inhaler to treat an acute asthma attack as directed by your doctor.

This section describes the usual dosage of Tezspire. Keep reading to learn more.

What are Tezspire’s forms?

Tezspire is available as a liquid solution that’s given as an injection under your skin by a healthcare professional. You or your caregiver may administer the Tezspire pre-filled pen after being trained by your healthcare professional.

The liquid solution comes in three forms:

  • a single-dose glass vial
  • a single-dose prefilled syringe
  • a single-dose prefilled pen

What strength does Tezspire come in?

Tezspire comes in one strength: 210 milligrams (mg) per 1.91 milliliters (mL).

What are the usual dosages of Tezspire?

The information below describes dosages that are commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for severe asthma

The typical Tezspire dosage for adults with severe asthma is 210 mg given once every 4 weeks. This drug is typically prescribed along with other asthma drugs.

If you have questions about your dosage of Tezspire, talk with your doctor.

What’s the dosage of Tezspire for children?

Tezspire is used to help treat severe asthma in children 12 years and older.

The dosage used in children is the same as the dosage for adults. To learn more, see the “What are the usual dosages of Tezspire?” section above.

For more information about Tezspire’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Tezspire used long term?

Yes, Tezspire is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely use it long term.

Tezspire is available as a liquid solution that’s given as an injection under your skin once every 4 weeks. It’s used with other medications to treat severe asthma.

You may receive all forms of Tezspire injections at your doctor’s office, a clinic, or another healthcare facility. You or your caregiver may also inject the Tezspire pre-filled pens after being trained by a healthcare professional.

Only a healthcare professional or your caregiver should inject the Tezspire pre-filled pen if you choose your upper arm as the injection site.

If you have questions about how you’ll receive Tezspire, talk with your doctor.

Note: Tezspire isn’t meant to treat sudden breathing problems from asthma attacks. Your doctor will likely recommend that you use a rescue inhaler (such as ProAir HFA) to treat any asthma attacks while you’re using Tezspire.

If you miss an appointment to receive a dose of Tezspire, call your doctor’s office as soon as possible to reschedule the appointment.

Once you receive the missed dose, your doctor will likely continue your Tezspire treatment based on your regular dosing schedule. If you have questions, your doctor can provide more information about your dosage.

If you need help remembering your appointments, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Below are answers to some commonly asked questions about Tezspire’s dosage.

Is Tezspire’s dosage similar to the dosage of Dupixent?

Tezspire and Dupixent have some similarities. However, their uses and dosages differ.

Tezspire (tezepelumab-ekko) is a biologic drug that’s used with other medications to treat severe asthma. Dupixent (dupilumab) is also a biologic drug. However, it’s used with other medications to treat moderate to severe eosinophilic asthma.

Dupixent is also used to treat other conditions such as moderate to severe atopic dermatitis (a type of eczema) and certain other conditions.

Tezspire comes in three single-dose forms: glass vial, prefilled syringe, or prefilled pen. It’s given as an injection under the skin by a healthcare professional once every 4 weeks.

Dupixent also comes as a liquid solution in single-dose prefilled pens or prefilled syringes. And it’s also given as an injection under your skin. However, you may receive Dupixent doses at your doctor’s office, or your doctor may show you how to give yourself the drug at home.

And when you start treatment with Dupixent, you’ll receive a loading dose of the drug. A loading dose is a higher dose of the medication that helps the drug start to work faster in your body. After the loading dose, you’ll receive doses every other week.

To learn more about how these drugs compare, talk with your doctor. They will prescribe the drug and the dosage that’s right for you.

How long does it take for Tezspire to start working?

Tezspire starts to work after you receive your first dose. But it may take several weeks before you notice an improvement in your symptoms. In studies, some people had an improvement in their asthma symptoms by 2 weeks after their first dose.

Your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

If you have other questions about what to expect from your Tezspire treatment, talk with your doctor.

The sections above describe the usual dosage provided by the manufacturer. If your doctor recommends Tezspire for you, they’ll prescribe the dosage that’s right for you.

Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Does my body weight affect my dosage of Tezspire?
  • Will I need a dosage adjustment for Tezspire if I have severe kidney problems?
  • How does the dosage of Tezspire compare with the dosage of Xolair (omalizumab)?

To learn more about Tezspire, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.