Tecentriq (atezolizumab) is a prescription drug that’s used to treat certain types of cancer, such as lung cancer. Tecentriq comes as a liquid solution for intravenous (IV) infusion.

Tecentriq is used in adults to treat certain cancers affecting the:

It may also be used in some children for certain types of soft tissue cancers.

To learn more about Tecentriq and how it’s used for these cancers, see the “What is Tecentriq used for?” section below.

Tecentriq basics

Tecentriq is an immunotherapy drug. It works with your immune system to fight off cancer. It contains the active ingredient atezolizumab. (An active ingredient is what makes a drug work.)

Atezolizumab is a biologic drug, which means it’s made from parts of living cells. It’s only available as the brand-name drug Tecentriq. It’s not available in a biosimilar form. (Biosimilars are like generic drugs. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic medications.)

Tecentriq comes as a solution that a healthcare professional will give to you as an intravenous (IV) infusion. With an IV infusion, the drug is injected into your vein over a period of time.

In this article, we describe Tecentriq’s uses, side effects, and more.

If you have certain types of cancer, your doctor may recommend Tecentriq. It’s used in adults with the following cancers:

Lung cancer: Tecentriq treats two common types of lung cancer called non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Specifically, the drug is used for the following:

  • As a first-choice treatment for SCLC that has spread to both of your lungs or to other places in your body. For this purpose, Tecentriq is given with the chemotherapy drugs carboplatin and etoposide.
  • As a first-choice treatment for NSCLC that has spread from your lungs to other parts of your body. For this use, the cancer must lack certain gene mutations (abnormal changes), but it must have certain proteins.
  • As a first-choice treatment for NSCLC that doesn’t affect certain lung cells called squamous cells. For this use, the cancer must have spread from your lungs to other parts of your body. And it must not have certain gene mutations. To treat this type of lung cancer, Tecentriq is given with bevacizumab (Avastin), paclitaxel, and carboplatin.
  • As a first-choice treatment for NSCLC that doesn’t affect certain lung cells called squamous cells. For this use, the cancer must have spread from your lungs to other parts of your body. And it must not have certain gene mutations. To treat this type of lung cancer, Tecentriq is given with protein-bound paclitaxel and carboplatin.
  • As adjuvant treatment for NSCLC that has not spread from your lungs or has spread nearby, after surgery and treatment with a platinum-based chemotherapy drug. (Adjuvant treatment occurs after other treatment for cancer. The goal of adjuvant treatment is to help prevent cancer from returning.) For this use, the cancer must have certain proteins.
  • As treatment for NSCLC that has spread from your lungs to other parts of your body and has worsened with certain previous treatment. (The previous treatment must have been made with platinum.) For this use, the cancer must have certain gene mutations, and it must have been treated with therapy made for cancer with those mutations.

Liver cancer: Tecentriq treats liver cancer that can’t be removed by surgery or that has spread from your liver to other parts of your body. You also must not have had systemic therapy previously for your liver cancer. (Systemic therapy is treatment that works throughout the body.) For this purpose, Tecentriq is given with bevacizumab (Avastin).

Skin cancer: Tecentriq treats a form of skin cancer called melanoma. For this purpose, Tecentriq is used for melanoma with a specific gene mutation. The cancer must also have spread from your skin to other parts of your body or can’t be removed by surgery. To treat this type of cancer, Tecentriq is given with cobimetinib (Cotellic) and vemurafenib (Zelboraf).

Tecentriq is also used in adults and children ages 2 years and older with the following cancer:

Soft tissue cancer: Tecentriq treats a form of soft tissue cancer called alveolar soft part sarcoma (ASPS). Soft tissue cancers such as ASPS form in the muscle, fat, nerves, or other soft tissue. Tecentriq is used to treat ASPS that can’t be removed by surgery or has spread to other parts of the body.

What Tecentriq does

Tecentriq is an immunotherapy drug. It targets a specific protein, called programmed death-ligand 1 (PD-L1), that some cancer cells have. This protein blocks the normal response of your immune system that kills cancer cells. By targeting PD-L1, Tecentriq activates your immune system to fight off cancer cells.

Like most drugs, Tecentriq may cause mild or serious side effects. The lists below describe some of the more common side effects that Tecentriq may cause. These lists don’t include all possible side effects.

Keep in mind that side effects of a drug can depend on:

  • your age
  • other health conditions you have
  • other medications you may be taking

Your doctor or pharmacist can tell you more about the potential side effects of Tecentriq. They can also suggest ways to help reduce side effects.

Mild side effects

Here’s a short list of some of the mild side effects that Tecentriq can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Tecentriq’s prescribing information.

Mild side effects of Tecentriq that have been reported include:

  • fatigue (low energy)
  • nausea*
  • cough
  • trouble breathing
  • loss of appetite

Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.

* For more information on this side effect, see the “Side effect focus” section below.

Serious side effects

Serious side effects from Tecentriq can occur, but they aren’t common. If you have serious side effects from Tecentriq, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number.

Serious side effects of Tecentriq that have been reported include:

* For more information on this side effect, see the “Side effect focus” section below.
† An allergic reaction is possible after using Tecentriq. But this side effect wasn’t reported in studies.

Side effect focus

Learn more about some of the side effects Tecentriq may cause.

Infections

If you’re receiving Tecentriq, you may have an increased risk of getting an infection. In fact, urinary tract infections (UTIs) and lung infections were common reasons why people stopped using Tecentriq during studies. Sometimes, these infections can become serious.

What might help

Symptoms of infection vary depending on the kind of infection you have. But possible symptoms to watch for include:

  • flu-like symptoms, including fever, chills, headache, body ache, fatigue (low energy)
  • cough
  • nausea, vomiting, or diarrhea
  • pain when urinating or frequent urination

If you think you have an infection while you’re receiving Tecentriq, tell your doctor. But do not stop receiving Tecentriq without first talking with your doctor.

It’s recommended that you do the following to help prevent lung infections:

And to help prevent UTIs, you can try:

  • urinating after having sex
  • staying hydrated and urinating regularly
  • taking showers instead of baths
  • avoiding douching or using sprays or powders on your genitals
  • wiping from front to back after urinating

Nausea

Nausea is one of the most common side effects of cancer drugs, including Tecentriq.

Many over-the-counter and prescription medications can help manage nausea. But before taking any medication for nausea, talk with your doctor or pharmacist. They can help make sure the product is safe for you.

What might help

If you have nausea while you’re receiving Tecentriq, tell your doctor. They might recommend medication to help lessen your nausea.

Besides taking medication, other ways to manage nausea include:

  • eating smaller, more frequent meals
  • staying away from odors that make you nauseous
  • avoiding spicy, fatty, or very salty foods

Immune system reactions

Tecentriq boosts the activity of your immune system to help it kill cancer cells. But with increased immune system activity, your body may start attacking your healthy cells, too. When your body attacks its own cells, you may have immune-mediated side effects.

Any cell in your body can be targeted by immune-mediated side effects. This includes cells in your:

  • lungs, possibly leading to pneumonitis (inflammation in your lungs)
  • intestines, possibly leading to colitis (inflammation in your colon)
  • liver, possibly leading to hepatitis (inflammation in your liver)
  • skin, possibly leading to rashes and painful skin sores
  • kidneys, possibly leading to nephritis (inflammation in your kidneys)
  • hormone glands, possibly leading to problems with hormones, including thyroid hormones

Additionally, if you have a solid organ transplant, immune-mediated side effects from Tecentriq may cause your body to reject the organ.

Immune-mediated side effects can occur while you’re receiving Tecentriq and after you stop receiving the drug.

What might help

During Tecentriq treatment, your doctor will monitor you closely for immune-mediated side effects. Noticing immune-mediated side effects and managing them early is key to safely using Tecentriq.

To monitor for immune-mediated side effects, your doctor will check certain blood tests. This allows them to make sure your kidneys, thyroid, liver, and other organs are working well.

If your doctor finds that you have any immune-mediated side effects, they may lower your dose of Tecentriq. Or, in some cases, they may have you stop using the drug. But do not stop receiving Tecentriq without first talking with your doctor.

Sometimes, you may need to take steroids or other drugs to treat immune-mediated side effects. These treatments help to lower the activity of your immune system for a while.

Allergic reaction

Some people may have an allergic reaction to Tecentriq. While allergic reaction wasn’t reported in studies of Tecentriq, it can still happen.

Symptoms of a mild allergic reaction can include:

  • rash
  • itchiness
  • flushing (warmth, swelling, redness, or discoloration in your skin)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.

Call your doctor right away if you have an allergic reaction to Tecentriq. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Find answers to some commonly asked questions about Tecentriq.

What’s the success rate of using Tecentriq?

Each person may have a different response to treatment with Tecentriq. Depending on the type of cancer you have, Tecentriq has a different success rate.

For example, studies show that people with non-small cell lung cancer can live longer when using Tecentriq compared with certain chemotherapy treatments. (See below for more information about chemotherapy drugs.)

Talk with your doctor about the success rate of using Tecentriq for your condition. If you’d like to learn more about results from studies of the drug, view Tecentriq’s prescribing information.

How does Tecentriq work?

Tecentriq contains the active ingredient atezolizumab, which is an antibody (type of protein). It targets (works on) specific cancer cells and immune system cells.

With cancer, certain parts of your immune system shut down and can’t eliminate the cancer cells. Tecentriq reactivates your body’s immune response. It blocks the growth of cancer cells and improves your immune system’s ability to kill cancer cells.

Is Tecentriq a chemotherapy drug?

No, Tecentriq isn’t a chemotherapy drug. Instead, it’s an immunotherapy drug.

Immunotherapy drugs are a type of cancer treatment that boosts the ability of your immune system to fight cancer. Chemotherapy, on the other hand, is a treatment that works on cancer cells and kills them itself.

Your doctor will recommend the dosage of Tecentriq that’s right for you. Below are commonly used dosages, but the dosage you receive will be determined by your doctor.

Forms and strengths

Tecentriq comes as a liquid solution that you’ll receive by intravenous (IV) infusion (an injection into a vein given over time). It is available in the following strengths: 840 milligrams (mg)/14 milliliters (mL) and 1,200 mg/20 mL.

Recommended dosages

For adults, the dose of Tecentriq depends on how often they receive the drug, which may be every 2, 3, or 4 weeks. Dosages for adults are as follows:

  • 840 mg every 2 weeks
  • 1,200 mg every 3 weeks
  • 1,680 mg every 4 weeks

Note that Tecentriq’s dosage is the same for the types of lung cancer, liver cancer, skin cancer, and soft tissue cancer Tecentriq treats. It is also the same regardless of whether a person takes other medications as part of their cancer treatment regimen.

Tecentriq is also used to treat soft tissue cancer in children ages 2 years and older. For this purpose, the drug’s dose is based on a child’s weight. A healthcare professional will calculate the correct dose for the child, which they’ll receive as an IV infusion every 3 weeks.

The maximum dosage of Tecentriq for children is 1,200 mg every 3 weeks.

For additional details about Tecentriq’s dosage, see this article.

Receiving Tecentriq

A healthcare professional will give you Tecentriq as an IV infusion. You’ll receive the drug in a doctor’s office, hospital, or infusion clinic.

Your first dose of Tecentriq will be administered over a period of 60 minutes. If you tolerate the first dose well, your next infusions may be given over 30 minutes instead.

Using Tecentriq with other drugs

You might need to use Tecentriq with other medications to treat your cancer. This is because some kinds of cancer require more than one type of cancer medication.

For example, if you’re using Tecentriq for liver cancer or a certain type of lung cancer, your doctor may prescribe bevacizumab (Avastin) together with Tecentriq. Avastin helps prevent blood supply from reaching cancer cells, leading to cell death.

Depending on the type of cancer you have, your doctor may prescribe other cancer drugs, including:

  • paclitaxel
  • carboplatin
  • etoposide
  • cobimetinib (Cotellic)
  • vemurafenib (Zelboraf)

Questions about using Tecentriq

Here are answers to some common questions about Tecentriq.

  • What if I miss a dose of Tecentriq? It’s important to go to all of your appointments to receive doses of Tecentriq. If you miss an appointment, call your doctor’s office as soon as possible and reschedule your treatment.
  • Will I need to use Tecentriq long term? Tecentriq treats advanced cancers, so you might need to receive it long term. Ask your doctor how long you’ll need to receive this medication given your condition. But keep in mind that if you experience severe side effects from Tecentriq, your doctor may switch your medication. Also, in some cases, your cancer may stop responding to Tecentriq. If your cancer worsens during treatment, your doctor may have you stop receiving Tecentriq.
  • Should I receive Tecentriq with food? You’ll receive Tecentriq as an injection into your vein over a period of time. How well your body absorbs this drug isn’t affected by whether you’ve eaten.
  • How long does Tecentriq take to work? Tecentriq starts to work with your immune system to help fight off cancer when you start receiving the medication. Your doctor will evaluate your cancer throughout this treatment to see how well it’s working for you.
Questions for your doctor

You may have questions about Tecentriq and your treatment plan. It’s important to discuss all your concerns with your doctor.

Here are a few tips that might help guide your discussion:

  • Before your appointment, write down questions like:
    • How will Tecentriq affect my body, mood, or lifestyle?
  • Bring someone with you to your appointment if doing so will help you feel more comfortable.
  • If you don’t understand something related to your condition or treatment, ask your doctor to explain it to you.

Remember, your doctor and other healthcare professionals are available to help you. And they want you to get the best care possible. So, don’t be afraid to ask questions or offer feedback on your treatment.

Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and whether you get the drug from a specialty pharmacy or receive it from a healthcare professional.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Tecentriq manufacturer’s website to see if it offers any support options for which you might be eligible.

Both Tecentriq and Imfinzi are cancer drugs that work with your immune system. They have different uses and different side effects.

To see a side-by-side comparison of these drugs, check out our “Imfinzi vs. Tecentriq” article. Talk with your doctor about which drug is best for you.

Some important things to discuss with your doctor when considering treatment with Tecentriq include:

  • your overall health
  • any medical conditions you may have

Tell your doctor if you’re taking medications. This is important because some medications may interfere with Tecentriq. These and other considerations are described below.

Interactions

Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions.

Before starting Tecentriq treatment, be sure to tell your doctor about all medications you take, including prescription and over-the-counter (OTC) types. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Tecentriq.

Interactions with drugs or supplements

It’s not known which drugs interact with Tecentriq. But you should still tell your doctor about any OTC or prescription medications you’re taking. Tell your doctor about any vitamins or supplements you’re taking as well.

If you think Tecentriq is interfering with another medication you’re taking, talk with your doctor or pharmacist.

Warnings

Tecentriq may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you start Tecentriq treatment. Factors to consider include those in the list below.

  • Immune system problems: Tecentriq works with your immune system to fight off cancer. So if you have an immune system condition, Tecentriq may not be the right drug for you. Examples of immune system conditions include Crohn’s disease, ulcerative colitis, and lupus. Also, tell your doctor if you’re receiving treatment for an infection. Tecentriq may affect how well your immune system can fight off the infection.
  • Allergic reaction: If you’ve had an allergic reaction to Tecentriq or any of its ingredients, you should not receive Tecentriq. Ask your doctor what other medications are better options for you.
  • Stem cell transplant: Serious complications, and even death, have been reported in people who received a stem cell transplant before or after using Tecentriq. If you need a stem cell transplant, tell your doctor about any use of Tecentriq.

Use with alcohol

Some medications interact with alcohol. Tecentriq isn’t one of them. But before starting Tecentriq, ask your doctor or pharmacist whether it’s safe for you to drink alcohol during Tecentriq treatment.

Pregnancy and breastfeeding

Tecentriq is harmful when used by people who are pregnant. Tecentriq boosts the activity of your immune system. If you become pregnant while using this drug, your immune system might attack the developing fetus.

If you can become pregnant, your doctor will check to make sure you’re not pregnant before prescribing Tecentriq.

If you’re a female* receiving Tecentriq, you should use an effective method of birth control to help prevent pregnancy during treatment. And you should keep using birth control for at least 5 months after your last dose of Tecentriq. If you’re a male* using Tecentriq, check with your doctor about whether you’ll need to use birth control.

It’s not known whether Tecentriq passes into breast milk. Because it’s not known whether Tecentriq is harmful to a child who is breastfed, it’s recommended that you avoid breastfeeding while receiving this drug. And you should avoid breastfeeding for at least 5 months after stopping the drug.

* In this article, use of the terms “male” and “female” refer to a person’s sex assigned at birth. For information about the difference between sex and gender, see this article.

If you have questions about Tecentriq, talk with your doctor or pharmacist. Your doctor can tell you about other treatments that may be used for your condition.

Some questions to ask your doctor about Tecentriq include:

  • Will Tecentriq cure my cancer?
  • Will I lose my hair if I’m receiving Tecentriq?
  • Which natural remedies can I use to help prevent immune-mediated reactions with Tecentriq?

To learn more about Tecentriq, see these articles:

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Q:

If I’m going to be traveling, can I switch from getting Tecentriq once every 2 weeks to getting it once every 4 weeks?

Anonymous

A:

It’s possible. But how frequently you receive Tecentriq will depend on your individual treatment plan and the type of cancer that’s being treated.

If you’d like to know about changing your dosing schedule with Tecentriq, it’s important to talk with your doctor. They can let you know if changing the frequency of your Tecentriq doses is a possibility.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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