Orladeyo (berotralstat) is a prescription drug that’s used to prevent swelling attacks caused by hereditary angioedema (HAE). The drug comes as an oral capsule that’s usually taken once per day.

Orladeyo is used in adults and in children ages 12 years and older to prevent swelling attacks caused by HAE.

The active ingredient in Orladeyo is berotralstat. (An active ingredient is what makes a drug work.) Orladeyo belongs to a group of drugs called kallikrein inhibitor.

This article describes the dosages of Orladeyo, as well as its strengths and how to take it.

To learn more about Orladeyo, see this in-depth article.

This section describes the usual dosages of Orladeyo. Keep reading to learn more.

What is Orladeyo’s form?

Orladeyo is available as an oral capsule.

What strengths does Orladeyo come in?

Orladeyo comes in two strengths: 110 milligrams (mg) and 150 mg.

What are the usual dosages of Orladeyo?

Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for hereditary angioedema

The typical Orladeyo dosage for adults with hereditary angioedema is 150 mg taken once daily with food.

You should not take more than one dose of Orladeyo per day.

What’s the dosage of Orladeyo for children?

Orladeyo is used to prevent hereditary angioedema in children ages 12 years and older.

The dosage used in children is the same as the dosage for adults. To learn more, see the “What are the usual dosages of Orladeyo?” section above.

For more information about Orladeyo’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Orladeyo used long term?

Yes, Orladeyo is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

Dosage adjustments

In certain situations, your doctor may prescribe a lower dosage of Orladeyo for you. This dosage is usually 110 mg taken once daily with food. Examples of these situations include:

  • having liver problems
  • having digestive problems due to Orladeyo
  • taking certain medications with Orladeyo

Orladeyo comes as an oral capsule. You’ll take one capsule once per day with food.

You should take your Orladeyo dose at the same time each day. This help keeps a steady level of the drug in your body.

If you have trouble swallowing capsules, see this article for tips on how to take this form of medication.

For information on the expiration, storage, and disposal of Orladeyo, talk with your doctor or pharmacist. You can also see the “Expiration” section of this article.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have trouble opening medication bottles. They may have tips to help, or they may be able to supply Orladeyo in an easy-open container.

If you miss a dose of Orladeyo, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at its usual time. If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

If you need help remembering to take your dose of Orladeyo on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.

Do not take more Orladeyo than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Taking more than the maximum recommended dosage of 150 milligrams (mg) per day may cause a serious heart rhythm problem called long QT syndrome. Symptoms may include:

  • heart palpitations (feeling like your heart is skipping a beat or added an extra beats)
  • fainting
  • making gasping sounds during sleep

What to do in case you take too much Orladeyo

Call your doctor right away if you think you’ve taken too much Orladeyo. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Orladeyo’s dosage.

Is Orladeyo’s dosage similar to the dosage of Takhzyro?

Orladeyo and anadelumab-flyo (Takhzyro) are both used to prevent swelling attacks caused by hereditary angioedema.

The forms and how often you take each drug are different. Orladeyo is an oral capsule, and Takhzyro comes as a liquid solution that’s given as an injection under the skin.

The dose in milligrams for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Orladeyo to start working?

Orladeyo starts to work after you take your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

If you have other questions about what to expect from your Orladeyo treatment, talk with your doctor.

The sections above describe the usual dosages provided by the manufacturer. If your doctor recommends Orladeyo for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Orladeyo without your doctor’s recommendation. Only take Orladeyo exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Should my dosage of Orladeyo change if I’ve had a transplant?
  • Will my dosage of Orladeyo need to be adjusted if I develop heart palpitations during treatment?
  • Does my Orladeyo dosage need to change if I plan to take herbal supplements with it?

To learn more about Orladeyo, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.