Orladeyo (berotralstat) is a prescription drug used to prevent swelling from a specific genetic disorder. Orladeyo’s cost may depend on factors including your dosage, whether you have health insurance, and the pharmacy you use.
Orladeyo is used in adults and children ages 12 years and older to prevent swelling attacks caused by hereditary angioedema.
Orladeyo comes as an oral capsule. It contains the active ingredient berotralstat. (An active ingredient is what makes a drug work.) It belongs to a group of drugs called plasma kallikrein inhibitors.
For more details on Orladeyo, see this in-depth article.
The price you pay for Orladeyo can vary. It may depend on your treatment plan, your insurance coverage (if you have it), and the pharmacy you use.
To find out how much you’ll pay for Orladeyo, talk with your doctor, pharmacist, or insurance provider.
Note: If you have insurance, you may need to get prior authorization before your insurance provider will cover Orladeyo. This means your insurer and your doctor will discuss Orladeyo in regard to your treatment. Then the insurance company will determine whether the drug is covered. If Orladeyo requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.
Be sure to ask your insurance company whether Orladeyo requires prior authorization.
Orladeyo only comes as a brand-name drug. It’s not currently available in a generic version. A generic contains an exact copy of the active drug in a brand-name medication but tends to cost less.
Why is there such a cost difference between brand-name drugs and generics?
Years of research and testing are needed to ensure that brand-name drugs are safe and effective. This testing can make the drugs expensive. The manufacturer of a brand-name drug can sell the drug for up to 20 years. After that, other drugmakers can create generic versions. This competition in the market can lead to lower costs for generics. And because generics have the same active ingredients as brand-name drugs, they don’t need to be studied again. This can also lead to lower generic costs.
If you take Orladeyo long term, you may be able to lower your costs in the following ways.
Look into getting an 84-day* supply of your medication. You may be able to get an 84-day supply of Orladeyo if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of Orladeyo. If you’re interested in getting an 84-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.
Use a mail-order pharmacy to get your medication. Using a mail-order pharmacy might help lower your cost for Orladeyo. Plus, you could get your medication without leaving home. Some Medicare plans may help cover the cost of mail-order drugs. You may also be able to get an 84-day supply of the drug through mail order. If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.
* If the option is offered and approved by your insurance provider, it’s possible to get a 90-day supply of many medications. Orladeyo comes in 28-day supply packs, so approximately 3 months’ worth of the drug would be 84 days instead.
If you need help covering the cost of Orladeyo or understanding your insurance, check out these resources:
On these sites, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.
If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.
If you still have questions about the cost of Orladeyo, talk with your doctor or pharmacist. They may be able to give you a better idea of what you’ll pay for this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for Orladeyo.
Examples of questions you may want to ask your doctor or insurance provider include:
- What is the cost difference between taking Orladeyo once daily to prevent swelling attacks and Kalbitor taken when necessary to treat swelling attacks from hereditary angioedema?
- What’s the cost difference between the 150-milligram (mg) and 110-mg capsules?
- What other, lower-cost drugs could I use to help prevent swelling attacks from hereditary angioedema?
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.