Letrozole is a generic prescription drug that’s used to treat certain types of breast cancer. Letrozole’s cost may depend on factors such as your dosage, whether you have health insurance, and the pharmacy you use.

Letrozole retail price
Save up to $537 per fill off of the retail price
The retail price of letrozole is $544. Save up to $537 per fill off of the retail price.

The price you pay for letrozole can vary. Your cost may depend on your treatment plan, your insurance coverage, and the pharmacy you use.

To find out how much you’ll pay for letrozole, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save using an Optum Perks coupon.

To save money on your letrozole prescription, explore these Optum Perks coupons.

Save on letrozole with Optum Perks

Save on letrozole without insurance.

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2.5mg letrozole (30 Tablets)

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Simply show the Optum Perks coupon at your preferred pharmacy and instantly save without using insurance. The coupon doesn't expire so be sure to save it for use with refills.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com


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Letrozole is a generic drug. A generic contains an exact copy of the active drug in a brand-name medication. A generic is considered just as safe and effective as the original drug but tends to cost less.

Letrozole is available in a brand-name version called Femara. To find out how the costs of Femara and letrozole compare, talk with your doctor, pharmacist, or insurance provider.

If you’ve been prescribed letrozole and you’re interested in taking Femara instead, talk with your doctor. They may prefer that you take one version instead of the other. In addition, you’ll need to check with your insurance provider. This is because it may only cover one drug or the other.

Why is there such a cost difference between brand-name drugs and generics?

Years of research and testing are needed to ensure that brand-name drugs are safe and effective. This testing can make the drugs expensive. The manufacturer of a brand-name drug can sell the drug exclusively for up to 20 years. After that, other drugmakers can create generic versions. This competition in the market can lead to lower costs for generics. And because generics have the same active ingredients as brand-name drugs, they don’t need to be studied again. This can also lead to lower generic costs.

If you take letrozole long term, you may be able to lower your costs in the following ways:

Look into getting a 90-day supply of your medication. You may be able to get a 90-day supply of letrozole if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of letrozole. If you’re interested in getting a 90-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.

Use a mail-order pharmacy to get your medication. Using a mail-order pharmacy might help lower your cost for letrozole. Plus, you could get your medication without leaving home. Some Medicare plans may help cover the cost of mail-order drugs. You may also be able to get a 90-day supply of the drug through mail order. If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need help covering the cost of letrozole or understanding your insurance, check out these resources:

On these sites, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.

Below are answers to some frequently asked questions about letrozole and cost.

What’s the cost of letrozole with insurance vs. without insurance?

The cost of letrozole with insurance versus without insurance can vary based on several factors.

Factors that may affect your cost of letrozole without insurance include:

  • your treatment plan and drug dosage
  • the pharmacy you choose
  • the quantity of letrozole you receive (such as a 30-day or 90-day supply)
  • any cost savings programs you qualify for

The same factors affect your cost of the drug if you’re paying through insurance. But in addition, your cost with insurance may depend on:

  • your individual plan benefits
  • any prior authorization requirements for your plan

To learn more about your cost with and without insurance, check with your doctor, pharmacist, or insurance provider (if you have one).

Whether you have insurance or not, you can visit Optum Perks* to get price estimates for letrozole when you use coupons from the site. It’s important to note that Optum Perks coupons cannot be used with any insurance copays or benefits.

* Optum Perks is a sister site of Healthline.

Does Medicare cover letrozole?

It’s possible. To find out whether your Medicare plan covers the cost of letrozole, call your plan provider. There are many different types of Medicare plans available, and your cost and coverage depend on your individual plan benefits.

Keep in mind that your plan may have prior authorization requirements before it will cover letrozole.

You can also ask your doctor about the cost of letrozole if you have Medicare.

If you have insurance, you may need to get prior authorization before your insurance provider will cover letrozole. This means your insurer and your doctor will discuss letrozole in regard to your treatment. Then the insurance company will determine whether the drug is covered. If letrozole requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.

Be sure to ask your insurance company whether letrozole requires prior authorization.

If you still have questions about the cost of letrozole, talk with your doctor or pharmacist. They may be able to give you a better idea of what you’ll pay for this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for letrozole.

Examples of questions you may want to ask your doctor or insurance provider include:

  • Does my cost of letrozole depend on the type of breast cancer the drug is being used to treat?
  • How does the cost of letrozole compare with the cost of Femara?
  • Are there other options if I can’t afford letrozole?

To learn more about letrozole, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.