Combigan (brimonidine/timolol) is a prescription drug that’s used to treat high eye pressure from certain conditions. The drug comes as an eye drop. It’s usually placed in the eye twice per day.

Combigan is used in certain adults and children. It treats high eye pressure from glaucoma or ocular hypertension.

The active ingredients in Combigan are brimonidine and timolol. (An active ingredient is what makes a drug work.) Brimonidine belongs to a group of drugs called alpha-2 adrenergic agonists. Timolol belongs to a group of drugs called beta-blockers.

This article describes the dosage of Combigan, as well as its strength and how to use it. To learn more about Combigan, see this in-depth article.

This section describes the usual dosages of Combigan. Keep reading to learn more.

What is Combigan’s form?

Combigan is available as a liquid solution that you use as an eye drop.

What strength does Combigan come in?

Combigan comes in one strength: brimonidine 0.2%/timolol 0.5%. The solution contains 2 milligrams (mg) of brimonidine plus 5 mg of timolol per milliliter (mL).

What are the usual dosages of Combigan in adults?

The information below describes dosages of Combigan that are commonly used or recommended. But be sure to use the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for certain high eye pressure in people with glaucoma or ocular hypertension

Combigan treats high eye pressure caused by glaucoma or ocular hypertension. Doctors may refer to high eye pressure as elevated intraocular pressure (IOP). (Ocular hypertension is a specific condition in which the eye has pressure higher than usual.)

The typical Combigan dosage for adults is one drop in the affected eye twice per day. You usually place each dose 12 hours apart.

What’s the dosage of Combigan for children?

Combigan treats high eye pressure caused by glaucoma or ocular hypertension in children ages 2 years and older.

The dosage for children is the same as the dosage for adults. To learn more, see the “What are the usual dosages of Combigan in adults?” section above.

For more information about Combigan’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Combigan used long term?

Yes, Combigan is usually used as a long-term treatment. If you and your doctor feel it’s safe and effective for your condition, you’ll likely use it long term.

Combigan is available as a liquid solution that you use as an eye drop.

You’ll place one drop of Combigan in the affected eye twice per day. If you use Combigan with other eye drops, separate doses of each drug by at least 5 minutes. This gives your eye time to better absorb each eye drop.

Before placing a dose of Combigan, it’s important to wash your hands. And when placing a dose, be sure not to touch the bottle tip to your eye. This is because bacteria on the tip of the bottle could enter your eye. The bacteria can lead to serious eye infections.

To learn more about how to use Combigan, visit the drugmaker’s website. You can also talk with your doctor or pharmacist.

For information on the expiration, storage, and disposal of Combigan, talk with your doctor or pharmacist. You can also see the “Expiration” section of this article.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

If you miss a dose of Combigan, talk with your doctor or pharmacist about what to do. They’ll tell you whether to place the missed dose or skip it.

If you need help remembering to place your dose of Combigan on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not use more Combigan than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Symptoms caused by an overdose can include:

What to do in case you use too much Combigan

Call your doctor right away if you think you’ve used too much Combigan. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Combigan’s dosage.

Is Combigan’s dosage similar to the dosage of Lumigan?

No, Combigan and Lumigan (bimatoprost) have different dosages.

Combigan and Lumigan are eye drops used to treat high eye pressure. Combigan’s dosage is one drop in the affected eye twice per day. Lumigan’s dosage is one drop in the affected eye once per day.

To learn more about how these drugs compare, talk with your doctor or pharmacist.

How long does it take for Combigan to start working?

Combigan starts to work after your first dose. You may not feel the drug working in your eye. But your eye specialist will monitor you during treatment. They’ll check whether the drug is working to treat your condition.

If you have questions about what to expect from your Combigan treatment, talk with your doctor.

The sections above describe the usual dosage provided by the drugmaker. If your doctor recommends Combigan for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Combigan without your doctor’s recommendation. Use Combigan exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Does my Combigan dosage need to change if I use other eye drops?
  • What should I do if I forget a dose of Combigan?
  • Do any of my medical conditions affect the dosage of Combigan I’m prescribed?

To learn more about Combigan, see this article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.