If you have migraine, your doctor might suggest Ajovy (fremanezumab-vfrm) as a treatment option.

Ajovy is a prescription medication that’s used to help prevent migraine headaches in adults.

This article describes the dosages of Ajovy, as well as its forms, strength, and how to take the drug. To learn more about Ajovy, see this in-depth article.

Note: This article covers the typical dosages of Ajovy injections. These dosages are provided by the drug’s manufacturer. But when using Ajovy, always take the dosage that your doctor prescribes.

Ajovy is given as an injection under your skin. Your doctor will show you how to give yourself Ajovy injections at home.

What are the forms of Ajovy?

Ajovy comes as a liquid solution in two forms:

  • single-use, prefilled syringe
  • single-use, prefilled autoinjector

What strength does Ajovy come in?

Ajovy comes in one strength: 225 milligrams (mg) in 1.5 milliliters of solution.

What are the typical dosages of Ajovy?

Typically, your doctor will start with the dosage that’s recommended to treat your condition. Then they’ll adjust your dosage over time to reach the right amount for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes Ajovy dosing that’s commonly used or recommended. But be sure to take the dosage that your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Ajovy has two recommended dosage schedules: either a monthly dosage or a quarterly dosage.

The usual monthly dosage of Ajovy is one injection (225 mg) given once per month. The usual quarterly dosage is three consecutive injections (for a total of 675 mg) given once every 3 months.

Talk with your doctor about your Ajovy dosage options. They’ll help you choose the best dosing schedule for your lifestyle.

Is Ajovy used long term?

Yes, Ajovy is typically used as a long-term treatment. If you and your doctor determine that Ajovy is safe and effective for you, it’s likely that you’ll use it long term.

Ajovy is given as an injection under the skin. Ajovy injections can be given into these areas of the body:

  • your abdomen (belly), avoiding the 2-inch area around your belly button
  • the front of your thigh, but not within 2 inches of your knee or groin
  • the back of your upper arm, a hard-to-reach area that can be used if a caregiver is injecting the dose for you

Avoid areas of your skin that are bruised, tender, or irritated.

It’s important to note that if you’re using Ajovy quarterly (every 3 months), you’ll give yourself three consecutive injections of the drug for each dose. You may choose the same area of your body for the three injections, but you shouldn’t use the exact same spot for each injection.

Your doctor will show you or a caregiver how to give injections of Ajovy. You can also watch a video with step-by-step instructions for using the prefilled syringe and prefilled autoinjector on the manufacturer’s website. Or you can read Ajovy’s prescribing information.

If you miss a dose of Ajovy, you should inject your missed dose as soon as you remember. Then, your dosage schedule should be adjusted based on the date you injected the missed dose.

For example, if you inject your missed dose on the 5th of the month, and you follow a monthly schedule, plan to inject future doses on the 5th of each month, too.

If you have questions about a missed dose, talk with your doctor or pharmacist.

If you need help remembering to take your dose of Ajovy on time, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

Don’t use more Ajovy than your doctor prescribes. Using more than this can lead to serious side effects.

What to do in case you use too much Ajovy

Call your doctor right away if you think you’ve used too much Ajovy. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use their online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The sections above describe the typical dosages provided by the drug’s manufacturer. If your doctor recommends Ajovy for you, they’ll prescribe the dosage that’s right for you.

Remember, you shouldn’t change your dosage of Ajovy without your doctor’s recommendation. Only take Ajovy exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Is there a loading dose of Ajovy?
  • Which dosage schedule of Ajovy might be best for me?
  • Which form of Ajovy (syringe or autoinjector) might be best for me?

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Can I inject Ajovy while the liquid is still cold, or should I let it warm up first?



Ajovy is stored in the refrigerator at a temperature of 36°F to 46°F (2°C to 8°C). Before using the drug, take it out of the refrigerator and let it sit at room temperature for 30 minutes.

You shouldn’t place Ajovy in direct sunlight, warm water, or another heat source in an attempt to warm it up faster.

If you leave Ajovy out of the refrigerator, it’ll stay good at a room temperature of up to 86°F (30°C) for up to 7 days. If you don’t use it within 7 days, throw it away in a sharps disposal container. You should not put Ajovy back in the refrigerator after it’s been left out at room temperature.

For more details on Ajovy’s expiration, storage, and disposal, see the drug’s prescribing information.

Patricia Weiser, PharmDAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.