Xifaxan (rifaximin) is a prescription drug used to treat some types of diarrhea and certain other conditions. Xifaxan’s cost may depend on factors such as your dosage, whether you have health insurance, and the pharmacy you use.
The price you pay for Xifaxan can vary. To find out how much you’ll pay for this drug, talk with your doctor, pharmacist, or insurance provider. Or check out the section below to learn how much you can save by using an Optum Perks coupon.
To save money on your Xifaxan prescription, explore these Optum Perks coupons.
Save on your Xifaxan prescription
Save on Xifaxan without insurance.
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550mg xifaxan (60 Tablets)
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Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.
Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.
Optum Perks and Healthline are subsidiaries of RVO Health.
Xifaxan only comes as a brand-name drug. It’s not currently available in a generic version. A generic contains an exact copy of the active drug in a brand-name medication but tends to cost less.
Why is there such a cost difference between brand-name drugs and generics?
Years of research and testing are needed to ensure that brand-name drugs are safe and effective. This testing can make the drugs expensive. The manufacturer of a brand-name drug can sell the drug exclusively for up to 20 years. After that, other drugmakers can create generic versions. This competition in the market can lead to lower costs for generics. And because generics have the same active ingredients as brand-name drugs, they don’t need to be studied again. This can also lead to lower generic costs.
If you take Xifaxan long term, you may be able to lower your costs in the following ways:
Look into getting a 90-day supply of your medication. You may be able to get a 90-day supply of Xifaxan if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of Xifaxan. If you’re interested in a 90-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.
Use a mail-order pharmacy to get your medication. Using a mail-order pharmacy might help lower your cost for Xifaxan. Plus, you could get your medication without leaving home. Some Medicare plans may help cover the cost of mail-order drugs. You may also be able to get a 90-day supply of the drug through mail order. If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.
If you need help covering the cost of Xifaxan or understanding your insurance, check out these resources:
On these pages, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.
If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.
Below are answers to some frequently asked questions about Xifaxan and cost.
What’s the cost of Xifaxan without insurance vs. with insurance?
The cost of Xifaxan without insurance versus with insurance can vary based on several factors.
Some factors that may affect your cost of Xifaxan without insurance include:
- your treatment plan and dosage
- the pharmacy you use
- the quantity of Xifaxan you’re prescribed (such as a 30-day or 90-day supply)
- any savings programs you qualify and apply for
The same factors affect your cost of the drug if you’re paying through insurance. But your cost with insurance may also depend on:
- your individual plan benefits
- any prior authorization requirements for your plan (see the “Prior authorization” section below for more information)
To find out more about your cost with and without insurance, check with your doctor, pharmacist, or insurance provider (if you have one).
Whether you have insurance or not, you can visit Optum Perks* to get price estimates for Xifaxan when you use coupons from the site. It’s important to note that Optum Perks coupons cannot be used with any insurance copays or benefits.
* Optum Perks is a sister site of Healthline.
Is Xifaxan covered by Medicare?
It may be. To find out whether your Medicare plan covers the cost of Xifaxan, call your plan provider. There are many different Medicare plans, and your cost and coverage will depend on your particular plan’s benefits.
Keep in mind that your plan may have prior authorization requirements before it will cover Xifaxan. (See the “Prior authorization” section just below for more information.)
You can also ask your doctor about the cost of Xifaxan if you have Medicare.
If you have insurance, you may need to get prior authorization before your insurance provider will cover Xifaxan. This means your insurer and your doctor will discuss Xifaxan in regard to your treatment. Then, the insurance company will determine whether the drug is covered. If Xifaxan requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.
Be sure to ask your insurance company whether Xifaxan requires prior authorization.
If you still have questions about the cost of Xifaxan, talk with your doctor or pharmacist. They may be able to give you a better idea of what you’ll pay for this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual price you’d pay for Xifaxan.
Examples of questions you may want to ask your doctor or insurance provider include:
- How does the condition I’m taking Xifaxan to treat affect my cost for the drug?
- What are my options if I can’t afford Xifaxan?
- How does the cost of Xifaxan compare with the cost of ciprofloxacin (Cipro)?
To learn more about Xifaxan, see these articles:
- All About Xifaxan
- Dosage Details for Xifaxan
- Side Effects of Xifaxan: What You Need to Know
- Xifaxan Interactions: Alcohol, Medications, and Others
To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.