How Short-Chain Fatty Acids Affect Health and Weight
Short-chain fatty acids are produced by the friendly bacteria in your gut.
In fact, they are the main source of nutrition for the cells in your colon.
Short-chain fatty acids may also play an important role in health and disease.
They may reduce the risk of inflammatory diseases, type 2 diabetes, obesity, heart disease and other conditions (1).
This article explores how short-chain fatty acids affect health.
Short-chain fatty acids are fatty acids with fewer than 6 carbon (C) atoms (2).
They are produced when the friendly gut bacteria ferment fiber in your colon, and are the main source of energy for the cells lining your colon.
For this reason, they play an important role in colon health (1).
Excess short-chain fatty acids are used for other functions in the body. For example, they may provide roughly 10% of your daily calorie needs (2).
About 95% of the short-chain fatty acids in your body are:
- Acetate (C2).
- Propionate (C3).
- Butyrate (C4).
Propionate is mainly involved in producing glucose in the liver, while acetate and butyrate are incorporated into other fatty acids and cholesterol (4).
Many factors affect the amount of short-chain fatty acids in your colon, including how many microorganisms are present, the food source and the time it takes food to travel through your digestive system (5).
Bottom Line: Short-chain fatty acids are produced when fiber is fermented in the colon. They act as a source of energy for the cells lining the colon.
One study of 153 individuals found positive associations between a higher intake of plant foods and increased levels of short-chain fatty acids in stools (7).
However, the amount and type of fiber you eat affects the composition of bacteria in your gut, which affects what short-chain fatty acids are produced (8).
For example, studies have shown that eating more fiber increases butyrate production, while decreasing your fiber intake reduces production (9).
- Inulin: You can get inulin from artichokes, garlic, leeks, onions, wheat, rye and asparagus.
- Fructooligosaccharides (FOS): FOS are found in various fruits and vegetables, including bananas, onions, garlic and asparagus.
- Resistant starch: You can get resistant starch from grains, barley, rice, beans, green bananas, legumes and potatoes that have been cooked and then cooled.
- Pectin: Good sources of pectin include apples, apricots, carrots, oranges and others.
- Arabinoxylan: Arabinoxylan is found in cereal grains. For example, it is the most common fiber in wheat bran, making up about 70% of the total fiber content.
- Guar gum: Guar gum can be extracted from guar beans, which are legumes.
Bottom Line: High-fiber foods, such as fruits, veggies, legumes and whole grains, encourage the production of short-chain fatty acids.
Short-chain fatty acids may be beneficial against some digestive disorders.
Inflammatory Bowel Disease
Ulcerative colitis and Crohn's disease are the two main types of inflammatory bowel disease (IBD). Both are characterized by chronic bowel inflammation.
Because of its anti-inflammatory properties, butyrate has been used to treat both of these conditions.
Studies in mice have shown that butyrate supplements reduce bowel inflammation, and acetate supplements had similar benefits. Additionally, lower levels of short-chain fatty acids were linked to worsened ulcerative colitis (15, 16).
Another small study found that butyrate supplements resulted in clinical improvements and remission in 53% of Crohn's disease patients (18).
For ulcerative colitis patients, an enema of short-chain fatty acids, twice per day for 6 weeks, helped reduce symptoms by 13% (21).
Bottom Line: Short-chain fatty acids may reduce diarrhea and help treat inflammatory bowel diseases.
Several observational studies suggest a link between high-fiber diets and a reduced risk of colon cancer. Many experts suggest the production of short-chain fatty acids may be partly responsible for this (28, 30).
In one study, mice on a high-fiber diet, whose guts contained butyrate-producing bacteria, got 75% fewer tumors than the mice who did not have the bacteria (33).
Interestingly, the high-fiber diet alone — without the bacteria to make butyrate — did not have protective effects against colon cancer. A low-fiber diet — even with the butyrate-producing bacteria — was also ineffective (33).
This suggests that the anti-cancer benefits only exist when a high-fiber diet is combined with the correct bacteria in the gut.
Yet these studies did not look into the gut bacteria, and individual differences in gut bacteria may play a role.
Bottom Line: Short-chain fatty acids have been shown to protect against colon cancer in animal and lab studies. However, more research is required.
A review of the evidence reported that butyrate can have positive effects in both animals and humans with type 2 diabetes (38).
Yet there are fewer studies involving people, and the results are mixed.
One study found that propionate supplements reduced blood sugar levels, but another study found that short-chain fatty acid supplements did not significantly affect blood sugar control in healthy people (46, 47).
Bottom Line: Short-chain fatty acids seem to help regulate blood sugar levels, especially for people who are diabetic or insulin resistant.
Studies have shown that short-chain fatty acids also regulate fat metabolism by increasing fat burning and decreasing fat storage (8).
Several animal studies have examined this effect. After a 5-week treatment with butyrate, obese mice lost 10.2% of their original body weight, and body fat was reduced by 10%. In rats, acetate supplements reduced fat storage (40, 56).
However, the evidence linking short-chain fatty acids to weight loss is based mainly on animal and test-tube studies.
Bottom Line: Animal and test-tube studies indicate that short-chain fatty acids may help prevent and treat obesity. However, human studies are needed.
Many observational studies have linked high-fiber diets to a reduced risk of heart disease.
However, the strength of this association often depends on the fiber type and source (57).
Butyrate is thought to interact with key genes that make cholesterol, possibly reducing cholesterol production (66).
Bottom Line: Short-chain fatty acids may decrease the risk of heart disease by reducing inflammation and blocking cholesterol production.
Short-chain fatty acid supplements are most commonly found as butyric acid salts.
However, supplements may not be the best way to increase your levels of short-chain fatty acids. Butyrate supplements are absorbed before they reach the colon, usually in the small intestine, which means all of the benefits for colon cells will be lost.
Additionally, there is very little scientific evidence about the effectiveness of short-chain fatty acid supplements.
Butyrate reaches the colon best when it's fermented from fiber. Therefore, increasing the amount of high-fiber foods in your diet is probably a much better way to improve your short-chain fatty acid levels.
Bottom Line: Eating high-fiber foods is the best way to increase short-chain fatty acid levels, as supplements are absorbed before reaching the colon.
Due to their anti-inflammatory and anti-cancer properties, it is likely that short-chain fatty acids have a wide range of beneficial effects on your body.
One thing is for certain: looking after your friendly gut bacteria can lead to a whole host of health benefits.
The best way to feed the good bacteria in your gut is to eat plenty of foods high in fermentable fiber.