Many popular pre-workout supplements are associated with side effects, including digestive issues, water retention, and headaches. Adjusting your dosage or avoiding supplements with certain ingredients may help.

To boost energy levels and performance during exercise, many people turn to pre-workout supplements.

These formulas generally consist of a flavored mixture of several ingredients, each with a specific role in improving performance.

Yet, some people experience side effects after taking them.

Here are 5 side effects of pre-workout supplements — plus some tips for how to avoid them.

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Caffeine is one of the primary ingredients in many pre-workout supplements.

This stimulant has been shown to increase muscle strength and output during exercise while reducing fatigue (1, 2, 3).

In theory, caffeine allows you to get more out of a given workout.

Nonetheless, caffeine has several potential side effects, especially if you consume too much. These include insomnia, nausea, increased heart rate, headaches, anxiety, and jitteriness or restlessness (4).

What’s more, many pre-workout supplements pack high amounts — up to 500 milligrams (mg) of caffeine per serving. Serving sizes typically range from 0.35–1 ounce (oz), or 10–30 grams (g).

In comparison, 1 cup, or 240 milliliters (mL), of coffee contains only 95 mg (5).

Ways to reduce side effects

Caffeine dosing is very individualized, as some people tolerate it better than others.

The best way to reduce side effects is to start with a small dose of a caffeinated pre-workout supplement, slowly increasing your dosage to see what you can tolerate.

Remember that it’s best to avoid caffeine for at least 6 hours before bed to help prevent sleeplessness, according to some older research (6).

Of course, you can also choose pre-workout supplements without any caffeine.


You’ll find caffeine in most pre-workout supplements, but this stimulant can cause jitteriness, anxiety, and an increased heart rate. If you experience side effects, try a smaller dose to see how your body reacts.

Another popular ingredient in many pre-workout formulas is creatine.

It has been shown to increase high intensity exercise capacity and lean body mass gains from exercise (7).

While it’s most often part of a pre-workout supplement, creatine can also be taken on its own.

The most common side effect associated with creatine is weight gain, which may be due to water retention. While there are anecdotal reports of other side effects — including digestive issues, dehydration, and muscle cramps — these have not been observed in clinical studies (7).

Ways to reduce side effects

Despite these side effects, creatine has been shown to be exceptionally safe (7, 8).

You can reduce any adverse symptoms by ensuring proper dosing.

Creatine is typically dosed with a loading phase of 5 g, four times per day for 5–7 days, followed by a 3–5-g daily maintenance dose. However, higher doses may be recommended in some cases (7).

This method provides rapid benefits — but has a higher potential to cause some anecdotal side effects, like digestive issues and bloating (7).

Alternatively, you can take a single daily dose of 3 g for 28 days. However, this option would increase muscle creatine content more gradually, meaning it will take longer to experience benefits for exercise performance (7).

Notably, it may be difficult to avoid moderate weight gain while taking creatine. This is mainly due to increased water retention in your muscles (7).


The easiest way to avoid mild side effects from creatine is to take smaller daily doses instead of doing a loading phase.

Two additional ingredients in many pre-workout supplements are beta alanine and niacin (vitamin B3).

Beta alanine is an amino acid that reduces acidity in your muscles during exercise, which may help you sustain your workout for slightly longer.

Dosed at 4–6 g per day, it has been shown to increase exercise performance and reduce fatigue in high intensity exercises lasting 1–4 minutes (9, 10).

Yet, this ingredient may cause paresthesia, a tingling sensation in your hands and feet. While it’s a harmless nervous system reaction, some people may find it uncomfortable (11).

Another ingredient with mild downsides is niacin, which is included in many pre-workout supplements for its skin-flushing effects. In high doses of 500 mg or more, it can trigger a blood rush to the surface of your skin, resulting in red patches (12).

While niacin also plays an important role in energy metabolism, supplementing with it likely doesn’t offer additional benefits if you consume a well-balanced diet (13).

Furthermore, one 2021 study even found that taking 1,000 mg of niacin before an aerobic workoiut actually impaired exercise performance (14).

Ways to reduce side effects

The most effective method to reduce the tingling associated with beta alanine is to divide the lower daily dose into separate doses of around 1.6 g each. Alternatively, you can buy sustained-release formulas that prevent this side effect (9).

Meanwhile, keeping your dose of niacin to less than 500 mg, avoiding hot showers immediately after taking niacin, or taking aspirin or ibuprofen before supplementation might also help prevent niacin flush (15, 16).

Alternatively, you can purchase niacin-free products by checking the ingredients on the label.


Beta alanine and niacin are two common ingredients in pre-workout formulas that may cause tingling and skin flushing, respectively. You can prevent these side effects by dividing or reducing your doses or selecting products without these compounds.

Several ingredients in pre-workout formulas may cause digestive upset.

These include sodium bicarbonate, magnesium, and caffeine.

Sodium bicarbonate may cause problems when consumed at doses higher than 0.3 g per kilogram of body weight. However, most pre-workout supplements do not contain this much (17).

Magnesium, on the other hand, may have laxative effects — especially in the form of magnesium citrate. Thus, taking too much may cause diarrhea (18).

Interestingly, using too little water when mixing pre-workout supplements may likewise upset your digestion. Too concentrated a liquid could lead to diarrhea (19).

Ways to reduce side effects

Mixing your pre-workout supplement with 8–12 oz (240–350 mL) of water can minimize side effects.

As it’s difficult to determine which ingredient is causing digestive issues, you may want to try different pre-workout formulas until you find one you can tolerate.


Several ingredients in pre-workout supplements may trigger digestive issues in some people. Mixing them with enough water can alleviate these effects.

Citrulline, which is added to some pre-workout supplements, is meant to increase blood flow to your muscles during exercise, resulting in enhanced muscle building.

This amino acid works by boosting nitric oxide levels in your blood (20).

The recommended dose for citrulline malate, a common form of this ingredient, is 6–8 g — though many pre-workout supplements offer smaller amounts and may not provide the potential benefits (20).

Keep in mind that this increase in blood flow affects your brain as well as your muscles. Theoretically, this could cause some people to experience headaches and migraines due to blood pressure changes in your brain’s small blood vessels (21).

Ways to reduce side effects

The most effective way to reduce headaches from citrulline is to decrease your dosage.

If you find that you still struggle with headaches, you may want to find a pre-workout supplement without this ingredient.


Citrulline, a common ingredient in pre-workout formulas, could theoretically cause headaches by increasing blood flow in your body. Decreasing your dosage may minimize this effect.

You don’t need to take a supplement to benefit from exercise.

However, if you’ve trained consistently for at least 6 months, pre-workout supplements may help increase your exercise capacity (22).

If you’re interested in trying a formula, look for a stamp from an independent lab that ensures quality. Testing companies included, U.S. Pharmacopeia (USP), and NSF International.

In addition, it’s always recommended to check ingredient lists for anything you may react to. You may also want to avoid proprietary blends, as these conceal the specific amounts of each ingredient used.


Pre-workout supplements may increase your exercise capacity if you maintain a wholesome workout regimen and diet, but they’re not necessary to attain good results.

Pre-workout formulas are popular in the fitness community due to their effects on energy levels and exercise performance.

However, you may experience side effects, including headaches, skin conditions, tingling, and stomach upset.

You can minimize many of these side effects by decreasing your dosage or avoiding supplements with particular ingredients.