Plexus Slim is a powdered weight loss supplement that you mix with water and drink.

It's sometimes called "the pink drink" because the powder turns the water pink.

Plexus Slim is claimed to help you lose weight by making you feel more full. It is also claimed to help reduce blood sugar and cholesterol levels.

The recommended dose is one drink per day, to be taken half an hour before a meal.

This article provides an objective and scientific review of Plexus Slim.

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Like many weight loss supplements, Plexus Slim is a mixture of ingredients, all of which are claimed to help with weight loss.

The main ingredients in Plexus Slim are:

  • Chromium: 200 mcg.
  • Plexus Slim Blend (green coffee bean extract, garcinia cambogia extract and alpha lipoic acid): 530 mg.

Plexus Slim powder comes in small packets. You’re meant to use one packet per drink.

Keep in mind that not a single scientific study has been done on Plexus Slim.

However, its four main active ingredients have been studied separately. Its manufacturer, Plexus Worldwide, claims that these ingredients — when combined — have a significant effect on your weight.

In order to determine if Plexus Slim is likely to work for weight loss, this article details each of the four ingredients separately.

Summary Plexus Slim contains chromium, green coffee bean extract, garcinia cambogia and alpha-lipoic acid.

Chromium is an essential mineral that plays an important role in metabolizing carbs, fat and protein.

For this reason, it's a popular ingredient in weight loss supplements. It's also sold as a weight loss supplement on its own.

Some studies indicate that chromium improves blood sugar control and insulin sensitivity, which can lower insulin levels (1, 2).

In the form of chromium picolinate, chromium has also reliably reduced some people's appetite and carb cravings (3, 4).

Because these effects could help you eat fewer calories and burn more fat due to lower insulin levels, some people speculate that chromium may aid weight loss.

However, although chromium appears effective in some people, research has yet to demonstrate that it consistently improves blood sugar and insulin sensitivity in everyone (5).

What’s more, studies have failed to reveal that chromium has any effect on body weight or body fat (6, 7, 8).

Summary While chromium does reduce blood sugar and improve insulin sensitivity in some people, studies haven't found any effect on weight or body fat.

Garcinia cambogia extract is a popular weight loss supplement extracted from a tropical fruit of the same name.

Several animal studies link massive weight and belly fat loss to garcinia cambogia (9, 10).

This effect may be caused by a natural substance found in garcinia cambogia known as hydroxycitric acid, or HCA.

HCA is thought to aid weight loss by impairing your body’s ability to store excess energy as fat. It does this by blocking a fat-producing enzyme called citrate lyase (11, 12).

Garcinia cambogia may also reduce your appetite by increasing levels of the hormone serotonin in your brain.

Despite the impressive weight loss seen in animals, the effects in humans have been much smaller and inconsistent (13, 14, 15, 16, 17, 18, 19).

One review noted that, over three months, the average weight lost by people taking garcinia cambogia supplements was just 2 pounds (0.88 kg) more than in those who took a placebo (12).

It's worth noting that many of the studies in this review combined garcinia cambogia with dieting, which may have influenced the results.

On its own, garcinia cambogia is unlikely to help you lose much weight.

Summary Garcinia cambogia is promoted as a fat-burning, cravings-reducing supplement. However, it hasn't proven very effective in humans.

Green coffee beans are simply coffee beans that haven't been roasted.

Like roasted coffee beans, green coffee beans contain some caffeine. In some studies, caffeine has been shown to increase metabolic rate by 3–11% (20, 21).

However, the potential weight loss effects of green coffee beans are believed to come from chlorogenic acid.

Unroasted coffee beans supply significant amounts of this compound.

Chlorogenic acid may decrease the number of carbs absorbed from your gut when you eat, leading to lower blood sugar and insulin levels (22, 23).

In animal studies, chlorogenic acid decreased body fat and improved the function of the fat-burning hormone adiponectin (24).

Some small human studies also provide positive results (25).

One 12-week experiment gave 30 obese people either regular instant coffee or instant coffee supplemented with chlorogenic acid. Those drinking the mixed coffee lost an average of 8.2 pounds (3.7 kg) more than the others (26).

However, many of the studies on green coffee beans have been quite small and sponsored by green coffee manufacturers (27).

What’s more, a recent meta-analysis pointed out that many such studies were poorly designed and may exaggerate the potential benefits (25).

Larger, robust studies are needed to determine if green coffee beans can help you lose weight (28).

Summary Green coffee beans have been associated with modest weight loss in some studies. However, the current evidence in humans is weak.

The final active ingredient in Plexus Slim is alpha-lipoic acid (ALA) — a fatty acid that plays an important role in energy metabolism.

It's a powerful antioxidant that may act as a weight loss aid (29).

Your body makes all of the ALA it needs. It also naturally occurs in foods, so you do get a small amount from what you eat.

Studies show that ALA can decrease blood sugar levels and help relieve symptoms of nerve damage in people with diabetes (30, 31, 32, 33).

Research also suggests that ALA supplements can reduce markers of inflammation associated with insulin resistance, liver disease, cancer, heart disease and several other health conditions (34, 35, 36, 37, 38, 39, 40).

In one small, 10-week study, women on a diet who also took ALA lost significantly more weight than those who followed the diet alone (41).

Other studies have found similar results (42, 43, 44, 45, 46).

However, many studies focusing on ALA and weight loss have used dosages of around 300 mg per day. It's not clear how much ALA is in Plexus Slim.

At the moment, most ALA studies are small and brief in duration. Larger studies are needed to assess its effectiveness.

Summary ALA may help you lose weight in the short term, but long-term results are unknown. It's also unclear if Plexus Slim contains enough ALA to aid weight loss.

No serious side effects have been reported for Plexus Slim, and it appears safe overall.

However, like many other diet supplements, more research is needed on its long-term effects and safety.

Some people have reported unpleasant but non-serious symptoms, such as bloating, gas, nausea, stomach ache and constipation.

Plexus Slim also contains caffeine, which can cause side effects such as headaches, dizziness, anxiety and insomnia if too much is taken.

Keep in mind that the symptoms listed above haven’t been confirmed as side effects of Plexus Slim.

At their recommended doses, the other ingredients in Plexus Slim are generally considered safe (12, 25, 47, 48).

However, at very high doses — above recommended amounts — some ingredients, such as ALA, could be dangerous (49).

Summary No studies have investigated the safety or side effects of Plexus Slim, but all the ingredients are considered safe at the recommended dosages.

Early research indicates that some of the ingredients in Plexus Slim may help you lose weight in the short term.

Keep in mind that it's unclear how much of these ingredients Plexus Slim contains. Therefore, it's impossible to know if they'll have a significant impact.

There also isn't any research about these ingredients’ effects on long-term weight loss.

All told, Plexus Slim may help you shed a little weight if combined with a healthy diet and exercise, but it is unlikely to help significantly on its own.