The internal pudendal artery serves oxygenated blood to the external genitalia of both males and females. It branches from the internal iliac artery.

This artery tends to be smaller in women and some of the branches of the artery are specific to each sex. In males, branches of the internal pudendal include the dorsal and deep artery of the penis, while females have dorsal and deep arteries of the clitoris. Women have posterior labial branches, whereas men have scrotal branches. There are additional other vessels specific to the genitals.

The inferior rectal and perineal arteries that branch off the internal pudendal are the same in both sexes.