In the foot, there are three cuneiform bones. They are the intermediate, lateral, and mediate cuneiforms. The intermediate cuneiform bone is located between its two counterparts and it articulates (forms a joint) with the second metatarsal, which is jointed to the bones of the second toe.

Collectively, the tarsal bones make up half of the foot, nearest the ankle, and the entirety of the ankle. The smallness of each bone, intermediate cuneiform included, allows for flexibility in the foot and the ankle, which joins with the tibia and fibula bones of the lower leg. This flexibility is a fundamental requirement to enable a person to use their foot for walking or any other types of bipedal (two-legged) movements.

The feet bear the entire weight of the body and, since walking requires constant impact with the ground, the tarsal bones of the feet are prone to fracture. Should the intermediate cuneiform break, the whole foot would need to be immobilized (usually in a cast). Otherwise, the multiple points of articulation could cause movement that may complicate healing.