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Urinary tract infections (UTIs) are never a pleasant experience, and shockingly, they’re extremely common.

UTIs occur when bacteria are pushed inside your urethra, causing an infection. The cause is often unknown, but common reasons include diet, hormones, gut imbalance, hygiene, travel, working out, and more.

About 50 to 60 percent of women get them, yet most of the options out there focus on treatment, not prevention.

Enter Uqora, a natural supplements brand that works to prevent UTIs before they begin by focusing on keeping your urinary health intact.

Uqora is a natural supplements company that focuses on developing supplements for UTI prevention. The brand was co-founded by Jenna Ryan and her partner, Spencer Gordon. Gordon has a background in biochemistry, so the two, alongside a team of urologists, began to research natural ways to prevent UTIs.

The company launched in 2017 with Uqora Target, a preventive drink mix that helps flush the urinary tract. Uqora focuses on UTI prevention rather than treatment, which is helpful, as constant trips to the doctor are often expensive and time-consuming. Not to mention, UTIs are painful and can lead to other concerns, like yeast infections and bacterial vaginosis.

The line is accessible to both men and women and is only sold on its e-commerce website. You can purchase products individually, in a bundle, or through a subscription plan.

Uqora products target infections caused by E. coli bacteria — the bacteria responsible for about 80 percent of uncomplicated UTIs.

The main ingredient in Uqora products is D-mannose, a sugar that works by binding with the bacteria that can cause UTIs and helping them get swept out with urine. If the source of your UTI is caused by bacterial biofilm that are already lodged in the bladder, D-mannose won’t work. It only targets free-floating bacteria.

You can purchase D-mannose supplements separately, but Uqora products also contain vitamins, antioxidants, electrolytes, and natural diuretics that can help flush everything out quicker.

If you’re someone who regularly gets UTIs, it’s important to ask your doctor to examine you for the root cause of your infections. If the source is E. coli, Uqora could be helpful. If it’s not, you may need to try another method, such as focusing on your gut microbiome and vaginal health.

None of Uqora’s products are guaranteed to prevent all UTIs, nor do they target bacterial or hormonal imbalances that can make you prone to UTIs.

Uqora products are safe for people of all ages, even children, as all the ingredients are generally recognized as safe by the FDA.

Target

Target is the company’s first launch and their most popular product. It’s a powdered drink mix meant to be consumed after sexual intercourse, working out, traveling, and anything that may put you at risk of a UTI. Just pour Target into an 8- to 12-ounce glass of water and drink every few days.

The main active ingredient in this powder is D-mannose. A recent clinical trial shows that a person taking D-mannose regularly is four times less likely to develop UTIs over 6 months.

Target also contains vitamin C, which helps support the immune system, and vitamin B6, a diuretic that helps increase urinary flow.

Control

While Target flushes the urinary tract when you need support, like after intercourse, Control is designed to keep the urinary tract clear on a daily basis.

Control is a set of vegan capsules that are meant to continually cleanse biofilm in the urinary tract and strengthen the bladder wall. Biofilm is a tool bacteria use to protect themselves and stay hidden. Microbial biofilms make it hard to treat UTIs, so Control works to break down existing biofilm and prevent it from recreating.

If you’re unsure what’s causing your UTIs, Control may be a good choice for you, as it “helps keep your bladder clean in the face of hard-to-pinpoint things like stress, hormonal changes, and holding your bladder,” according to the company.

The active ingredients in this product are black pepper powder, D-mannose, green tea extract, vitamin D3, and curcumin, which has been found to help reduce bladder infections in rats. Each bottle comes with a 30-day supply.

Promote

Promote is a daily vegan probiotic for vaginal and urinary health. It’s not a digestive probiotic, rather it focuses on restoring and maintaining the good bacteria that balance the vaginal microbiome and protect you from future UTIs. You can take it along with your digestive probiotic.

Typically, when you get a UTI, you’re prescribed an antibiotic, as it’s currently the most effective treatment. Unfortunately, antibiotics tend to kill helpful bacteria in the process, which then allows bacteria like E. coli to flourish.

Promote consists of three strains of good bacteria to maintain a healthy vagina: Lactobacillus acidophilus, Lactobacillus rhamnosus, and Lactobacillus reuteri.

Each bottle comes with a 30-day supply, and you’re instructed to take 1 capsule with water daily.

Bundles

Uqora offers up to 20 percent off when you purchase more than one product within the same order. By bundling all three products together, you can save about 32 percent of the cost of purchasing all three items separately.

If you decide that you want all three of Uqora’s products, it may make the most financial sense to purchase the Complete System, which contains Target, Control, and Promote for $80.

You can take all three of these products in the same day for maximum urinary support: Target flushes the urinary tract, Control cleanses biofilm from the urinary tract and cleanses the bladder wall, and Promote balances the vaginal microbiome.

The only con with the bundles is that if you successfully prevent future UTIs, it’s nearly impossible to isolate which product made the biggest impact.

Subscription

By choosing to go with a subscription plan, you can save up to 35 percent. After taking the quiz on the website to figure out your needs, you can then decide what products you want to bundle and how much you need. Target allows you to choose between 10, 20, or 30 packets, and you can change this amount at any time.

If you choose the Complete System subscription, you’ll get a 1-month supply of Control, a 1-month supply of Promote, and your selected choice of Target packets.

Your subscription renews every 4 weeks, and you have the flexibility to manage your shipment dates, renewal frequency, and products. Uqora sends you renewal notification emails a few days before your order renews, and there are no penalties for canceling.

Target retails at $30 for 10 packets, $55 for 20 packets, and $75 for 30 packets. A month’s supply of both Control and Promote comes out to $30. Signing up for a subscription plan allows you to save 15 percent individually, and 35 percent if you bundle all three items together.

Uqora offers a student discount program. Reach out to their support team at support@uqora.com using your school email address.

The brand doesn’t currently offer any free trials, but all of their products have a no-questions-asked free-return policy.

Uqora’s products are now health savings account (HSA) and flexible savings account (FSA) approved, which means that you can use your HSA or FSA card at checkout.

To use your HSA dollars on the supplements, you’ll need your doctor to fill out this one-page form, which validates that they consider Uqora’s products to be medically necessary for your health.

Uqora currently doesn’t have any pending lawsuits.

All the ingredients in Uqora products are generally recognized as safe by the FDA, but the products aren’t approved by the FDA to treat or prevent any disease.

There are currently more than 9,000 reviews on the Uqora website, with more than 8,000 5-star reviews. There are only a few negative reviews on the site. The consensus is that their products, mainly Target, work effectively to help prevent UTIs.

The age groups of the women reviewing the products range from 21 to 80 years old, so the products appear to be helpful for most age groups. A lot of testimonials claim that Target changed their life and that they’d recommend it to other women.

A common complaint is that the product is overpriced, considering you can purchase D-mannose and multivitamins separately for cheaper.

Are there any side effects?

Uqora’s ingredients are recognized as safe by the FDA with minimum side effects. D-mannose, an active ingredient, can cause some gastrointestinal issues like bloating or loose stools. If you have diabetes, talk with your doctor before taking D-mannose, as it is a form of sugar.

Uqora also doesn’t specify which D-mannose they use, and since most D-mannose on the market is made from corn, it’s a possible allergen for many.

Uqora recommends checking in with your doctor before trying their products.

Does Uqora work for men?

Yes. The only product that wouldn’t work for men is Promote, since it’s a vaginal probiotic. The other two products are safe for men and especially helpful for those using a catheter.

How often can you consume it?

The brand recommends taking no more than 8,000 milligrams (mg) of D-mannose in a day.

There are 600 mg in 2 capsules of Control and 2,000 mg in a packet of Target, so you’ll be well under that number even if you’re taking both capsules and a packet of Target each day.

The company recommends taking Target at least every 3 days, but you can safely take it up to 4 times in 1 day.

While there isn’t a ton of research on the effects of D-mannose when taken by people who have UTIs, preliminary research and thousands of positive reviews on Uqora’s website show it might be worth trying if you experience recurrent UTIs.

Iman Balagam is a writer based in Houston, Texas. When she’s not laughing at her own jokes, or buying overpriced chia pudding, she can be found reading fiction novels, catching a spin class, doomscrolling through TikTok, or waiting for her delayed Spirit flight to board. You can see more of her work on her website.