Waldenstrom macroglobulinemia is sometimes known as Waldenstrom’s or WM. It’s a rare type of non-Hodgkin’s lymphoma. Lymphomas are cancers that start in cells called lymphocytes, a type of white blood cell. Lymphocytes play an important role in the immune system.
WM is a cancer of the B lymphocytes or B cells, a type of immune cell. Healthy B cells become plasma cells. Plasma cells create antibodies to fight off harmful bacteria or viruses.
WM damages the B cells so they no longer function normally. The excess production of cancerous B cells prevents healthy B cells from being made. It can also block the bone marrow from making other types of healthy blood cells.
Cancerous B cells make too many IgM antibodies. IgM antibodies are large proteins. Excess IgM can thicken the blood and cause problems with some organs in the body.
If you or a loved one is diagnosed with WM, you probably have questions. Here are some FAQs and answers about this condition to help you learn more.
WM is a slow-growing type of cancer. People can live for years without symptoms and not even know they have it. WM is often diagnosed after routine bloodwork shows changes in blood cell levels.
It’s impossible to predict exactly how long someone will live after a diagnosis of WM. There are many factors that influence a person’s life expectancy.
There is no standard staging system for WM like there is for some other types of cancer. In the early 2000s, a WM scoring system was developed to group patients into
Using this scoring system, a study was done to explore life expectancy. Survival ranged from 5 years for the high-risk group to 12 years for the low-risk group. That study used data from before 2002, so the survival data is now outdated.
New therapies mean that people are living longer with WM. Now, the median survival rate for patients after diagnosis is 14 to 16 years. Keep in mind that this is based on when the diagnosis is made. Some people may have already been living with WM for many years without knowing it.
The average age of diagnosis for WM is
WM is a type of non-Hodgkin’s lymphoma. Lymphomas are a group of cancers involving lymphocytes, a type of white blood cell.
WM targets the B lymphocytes, also known as B cells. These cells have an important job as part of the immune system response. B cells become plasma cells, which make antibodies to fight off infections.
In WM, cancerous B cells create large antibodies called IgM. Excessive IgM in the blood can make it thicker.
WM is considered a slow-growing type of cancer. It’s possible to have it for several years and not know it. Many people have no symptoms. There is no cure for WM, but treatments can help manage symptoms or complications of WM.
Symptoms of WM can be related to the changes in white and red blood cells in the body. They can also be related to thicker blood from high IgM concentrations.
Signs and symptoms of WM can include:
- unexplained weight loss
- low hemoglobin levels
- feeling short of breath
- swollen abdomen (from an enlarged liver or spleen, where IgM can build up)
- numbness and tingling in the hands and feet, from nerve damage
If there are no symptoms, treatment may not be necessary. Your doctor will monitor blood levels and symptoms to watch for any changes. Some people will never need treatment.
Different medications are available to treat WM. If you need treatment, your doctor will discuss the best options with you. Treatments help slow the growth of cancerous B cells and manage symptoms of WM.
If a buildup of IgM is making your blood too thick, you may need to undergo a procedure called plasmapheresis. During this procedure, a medical professional will insert a needle or catheter into your arm and a pump will slowly remove your blood. Your blood will go through a filtering machine to remove excess IgM. As the blood is thinned out to a normal level, it gets returned to your body.
Family history may slightly increase the risk of developing WM. In about 20 percent of cases of WM, there is a family history of WM or another blood cancer that affects B cells.
In most cases, WM, just like other cancers, is caused by a random mistake in a cell’s DNA. These genetic errors mean the cell no longer works properly. Damaged cells create more damaged cells, resulting in cancer. We usually don’t know exactly what triggers the DNA error in the first place.
WM is a rare form of blood cancer. There are about
WM is more likely to be diagnosed in people in their 60s and 70s. It’s also more common in men.
A condition called monoclonal gammopathy of undetermined significance (MGUS) is linked to WM. MGUS causes a higher than normal amount of IgM antibody in the blood, but not at the level seen in WM.
MGUS is not cancer, but it slightly increases the odds of developing WM or some other blood cancers. Every year,
People with MGUS are monitored for any change in symptoms or blood levels.
Waldenstrom macroglobulinemia (WM) is a rare type of lymphoma. This cancer affects the B cells or B lymphocytes. These are a type of white blood cell involved in the immune response. Many people live with WM for years with no symptoms. It is a slow-growing type of cancer that often doesn’t need any treatment.
Advances in treatment mean that people are living longer with WM. The median survival after diagnosis is now 14 to 16 years. People with WM are monitored by a healthcare team to watch for changes in symptoms or blood levels. If treatment is needed, there are several options to help manage WM.