Immune thrombocytopenia (ITP), previously known as idiopathic thrombocytopenia, is a rare blood disorder characterized by low platelet counts, which affect the blood’s ability to clot.

According to the National Organization for Rare Disorders, more than 200,000 people worldwide have ITP.

For many people, ITP doesn’t cause symptoms. When they do appear, platelet levels are often very low, which leads to excessive bleeding.

A normal platelet count is needed to control bleeding throughout the body. Most of the time, the bleeding is contained underneath the skin and appears as a bruise, so you might dismiss ITP-related symptoms as something else.

Other more serious symptoms of ITP can be related to more significant internal or external bleeding.

Some signs of ITP may seem unusual. Be on the lookout for the following symptoms, and call your doctor with any concerns you might have.

One of the most common symptoms of ITP is a skin condition called petechiae. These are small red bumps on your skin caused by bleeding from underneath.

Petechiae can look like a red rash at first, but the bumps are slightly raised, scattered, and the size of pinpoints. They can also have a purplish tinge.

If you notice petechiae or any unusual rash, see a healthcare professional for diagnosis and treatment.

Bruises are the result of injuries that cause capillaries to break just underneath the surface of the skin. Blood comes out of these broken capillaries, forming a pool. This creates black-and-blue bruises.

Bruises become yellow and fade over time as the blood reabsorbs into the body. They’re not usually cause for concern.

There can be many reasons for bruising, including:

  • thinning of the skin, like from aging or another cause
  • herbal supplements
  • medications
  • sun damage

However, you might notice you’re bruising a lot more easily, especially on your arms and legs. You might even wake up with bruises, or get new bruises without having been hurt.

Sometimes bruising easily is a symptom of ITP. Low levels of blood platelets can make it more difficult for your blood to clot, causing the skin to bruise even after a minimal injury.

Bruises from ITP are called purpura. They’re usually purple. They can even appear inside your mouth.

When we think of the word “skin,” the gums may not come to mind at first. But ITP can affect this delicate skin too.

According to the National Heart, Lung, and Blood Institute, gum bleeding from ITP may occur during dental work, like a routine teeth cleaning or other dental procedures.

In severe cases, your gums could bleed from brushing and flossing.

You may attribute this bleeding to gingivitis (gum inflammation) instead of an ITP symptom. At your cleanings, your dentist may also notice bruises inside your mouth.

Nosebleeds (epistaxis) occur when the delicate skin inside your nose bleeds. Nosebleeds can be relatively common and have a variety of causes, including:

  • allergies
  • colds
  • sinus infections
  • blood-thinning medications

If you find yourself having many weekly nosebleeds despite being well and keeping your nose moist, see a healthcare professional to determine the cause and get treatment.

Low platelet counts from ITP can affect your menstrual cycle, making periods heavier than usual.

While heavy periods might seem more like a nuisance than anything else, they can also lead to complications, such as anemia.

An occasional heavy menstrual cycle might not be cause for concern. But if you begin experiencing a heavy period every month, see a healthcare professional.

The low platelet count associated with ITP can also cause bleeding in your urine or stools. At first, you might mistake urine in the blood as a sign of infection. However, bladder infections often accompany other symptoms, such as:

  • lower back or flank (kidney) pain
  • frequent urination
  • abdominal pain

Blood in the stool is never normal. If you see blood in your urine or stools, follow up with a healthcare professional. It could be a sign of ITP.

ITP can also cause small lumps underneath the skin. These are called hematomas. They’re made of areas of clotted blood that pooled in the tissue deep underneath your skin.

A hematoma is a type of deep bruise. It typically only occurs with a moderate injury.

See a healthcare professional for any bumps on the skin or bumps within deeper tissues.

Red blood cells transport oxygen throughout your body, which helps your tissues and organs function properly. When you bleed, your body takes time to replace the blood.

In cases of moderate bleeding, this can lead to anemia due to fewer-than-needed red blood cells. You might feel overly fatigued as a result.

Signs of excessive fatigue include:

  • needing more sleep than usual
  • requiring daytime naps
  • feeling tired during the day despite getting a good night’s sleep
  • overall lack of energy for everyday activities

If you have any signs or symptoms of anemia, see a healthcare professional for diagnosis and treatment.

Excessive fatigue can affect more than your physical energy. It can affect your mental energy, too.

This may result in difficulties in school, work, or your social life. It can also lead to depression and anxiety when not treated.

It’s important to know about the symptoms of ITP. That way, if you do experience any of them, you’ll be able to seek medical attention to help keep your symptoms from getting worse.

If you do notice any of these symptoms, make an appointment with a doctor. They’ll be able to make sure you’re receiving the proper diagnosis and treatment.