Your DNA is located within the nuclei of your cells, where it’s bundled within structures called chromosomes. Each chromosome carries specific genetic information in the form of genes. As the cells in your body divide, your chromosomes need to replicate so that each cell contains a complete set of chromosomes in its nucleus.
At the ends of each of your chromosomes are stretches of DNA called telomeres. Telomeres help protect the ends of your chromosomes from damage or fusing with nearby chromosomes.
Keep reading to learn more about these tiny but important structures and why they could unlock the door to preventing disease and reducing the effects of aging.
Your DNA strands become slightly shorter each time a chromosome replicates itself. Telomeres help prevent genes from being lost in this process. But this means that as your chromosomes replicate, your telomeres shorten.
That’s where an enzyme called telomerase comes in. It’s found in certain cells and helps prevent too much wear and tear. This includes shortening of your telomeres. Telomerase does this by adding additional telomere sequences to the ends of your chromosomes.
Most of the cell types in your body don’t have telomerase. This means that most of your telomeres continue to get shorter over time.
Some people claim that telomere shortening is a major contributor to the aging process and development of disease. But no one fully understands the impact that telomere shortening has on our overall health.
But this study is nearly 20 years old and only involved 143 participants. More recent meta-analyses also suggest connections between shorter telomeres and
While it’s known that chromosome replication shortens telomeres, some experts believe oxidative stress can also shorten them. Oxidative stress refers to damage to DNA and other biomolecules from reactive oxygen species.
Reactive oxygen species are created by both natural cellular processes within your body and inflammation. You can also acquire them from your environment through things such as pollution, smoking, or alcohol consumption.
Over time, the damage to DNA and other biomolecules caused by oxidative stress may contribute to health problems associated with aging. Again, this is a fairly new area of research, so there’s not much definitive evidence.
Shorter telomeres are
In addition, one of the hallmarks of cancer cells is that they grow and divide rapidly compared to other cells. So, how do cancer cells not aggressively shorten their telomeres and die off?
Telomerase, the enzyme that reduces telomere shortening in certain cells, is reactivated or increased in more than
Based on this information, some new cancer treatments target telomerase to help destroy cancer cells faster.
Given the links between telomere shortening and disease, some people are now interested in finding ways to lengthen their telomeres. But is this even possible?
Research surrounding telomere lengthening is still very new. But so far, the results do show some promise. While it’s unclear if you can actually lengthen your telomeres, there are likely ways to slow down the shortening process.
For example, a
- following a healthy diet
- getting regular exercise
- managing stress through yoga and support groups
Compared to the 25 participants with low-risk prostate cancer who didn’t make the lifestyle changes, the 10 who did had longer telomeres five years later. Again, this was a very small study, and it only involved men.
However, this small study provides a foundation for more recent research surrounding the effects of diet, exercise, and stress management on telomere length.
Your diet may play a role in determining the length of your telomeres. A
On the other hand, another
When you’re stressed, your body releases hormones that can cause oxidative stress. This could result in more DNA damage and telomere shortening. Based on this information, reducing stress should help to reduce oxidative stress — and studies show that it does.
Regardless of whether it reduces telomere shortening, stress management is a crucial part of feeling your best. Not convinced? See how stress affects your body.
Exercise has a range of health benefits, including reducing inflammation and oxidative stress.
A 2017 study involving thousands of men and women in the United States looked at the connection between exercise and telomere length. Those who participated in high levels of activity had significantly longer telomeres than those who did low or medium levels of activity. There wasn’t a noticeable difference between those with low physical activity and those with medium levels.
Telomeres help protect your chromosomes from damage. In the process, your telomeres shorten, which is associated with aging and disease development. But recent research suggests that there may be ways to hack this process through diet, stress management, and exercise.
While these findings are all very preliminary, we already know that an active lifestyle, along with a nutritious diet and stress management techniques, provide a multitude of other health benefits as well.