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If you’re not feeling noticeable effects from CBD, it may be time to try a stronger dose. Not all high potency products passed our vetting process due to regulatory issues, but these three get the green light.

Whether you’re taking cannabidiol (CBD) to help with sleep, chronic pain, or anxiety, the right dose can vary from person to person.

High potency CBD might be a fit for you if you’re not seeing noticeable effects at lower doses. Generally, high dose CBD refers to a product containing at least 25 milligrams (mg) of CBD per gummy.

What feels strong to you, though, might not affect someone else in the same way. The type of CBD can alter its effectiveness, too. Full-spectrum products, for example, are more likely to produce obvious effects because of the interaction between CBD and THC. This phenomenon has been dubbed the entourage effect.

It’s important to point out that stronger full-spectrum gummies also come with a greater amount of tetrahydrocannabinol (THC), which can increase your risk of experiencing side effects.

Keep reading to learn more about the strongest CBD gummies and how to safely use them.

Each gummy product pick contains at least 25 mg of CBD per serving (typically 1 or 2 gummies). We used the following criteria to narrow down our picks and select products that meet our standards for safety and quality.

Each product in this article:

  • is made by a company that provides proof of third-party testing by an ISO 17025-compliant lab
  • is made with U.S.-grown hemp
  • contains no more than 0.3% THC, according to the certificate of analysis (COA)
  • passes tests for pesticides, heavy metals, and molds, according to the COA

As a part of our selection process, we also considered:

  • the company’s certifications and manufacturing processes
  • product potency
  • overall ingredients
  • indicators of user trust and brand reputation, such as:

Aside from potency, here’s what to consider when shopping for the strongest CBD gummies.

CBD source

There are three forms of CBD to choose from: isolate, broad-spectrum, and full-spectrum.

CBD isolate contains no other cannabinoids other than CBD and is a good option for people who want to steer clear of THC. But because CBD isolate products don’t contain the full range of terpenes, cannabinoids, and flavonoids, they may not produce as strong an effect as products that do.

Full-spectrum CBD includes all the cannabinoids along with THC, which helps produce the entourage effect. U.S.-grown hemp can’t contain more than 0.3% THC legally, but it’s still a good idea to read labels and check a product’s COA to ensure there isn’t more THC than listed.

Broad-spectrum products typically contain some cannabinoids but no THC.


CBD gummies might also contain other ingredients like flavorings and sweeteners. Some may also contain added ingredients like vitamins, but there’s not enough research to say that mixing CBD with vitamins and supplements is safe.

If you’re vegan or have any other dietary restrictions, make sure to check the ingredient list.

You’ll want to look for gummies that contain non-synthetic, organic ingredients.


If there’s no COA readily available, that’s a red flag. The FDA doesn’t regulate CBD like it does prescription drugs, so it’s kind of the Wild West out there.

A COA lets you know a product has been tested by a third-party lab for contaminants and that the label is accurate.

Many studies looking into the effects of CBD involve higher doses.

One 2017 study found that CBD doses of between 300 and 600 mg helped decrease public speaking-related anxiety. However, the researchers of another study looking at the effects of CBD on sleep point out that lower doses seem to produce enough of a clinical effect, and higher doses in the hundreds of milligrams are cost-prohibitive.

Keep in mind that what works for someone else, might not work for you. Some people may respond well to lower doses without needing to try higher potency products.

It’s also important to note that CBD isn’t a cure-all, and it may not produce any effects for some people. Plus, more research is necessary to fully understand the benefits and full range of effects that CBD can provide.

You probably don’t want to take a 50 mg gummy when trying CBD for the first time. It’s a good idea to work your way up to stronger gummies. You may even discover that a lower dose does the trick.

CBD won’t get you “high” like cannabis, which contains higher amounts of THC, but it may still produce side effects, especially at higher doses. Possible side effects include:

  • nausea
  • changes in appetite
  • changes in weight
  • diarrhea

There’s also evidence that CBD ingestion can affect medication absorption. And taking CBD with high fat meals may heighten the risk of side effects by increasing your CBD blood concentration.

Always talk with a healthcare professional before taking any over-the-counter supplement, including CBD.

Is 500 mg CBD gummies strong?

Yes, 500 mg is extremely strong for a CBD gummy.

What is the highest milligram for a CBD gummy?

50 mg is typically the strongest CBD gummy you can find, but some companies offer higher dose gummies of 100 mg or more.

What are the most powerful legal gummies?

Most high potency CBD gummies fall somewhere between 25 and 50 mg per serving. Nuleaf Naturals, Cornbread Hemp, and Sunday Scaries gummies are our top picks for strong CBD gummies.

What are the best CBD gummies for chronic pain?

A high potency, full-spectrum CBD gummy is probably the best choice if you’re dealing with chronic pain. We like Nuleaf Naturals, Cornbread Hemp, and Sunday Scaries gummies.

What’s strong for one person may not be for another, but high potency gummies typically range from 25–50 mg per serving.

A higher dose may be just what you need to get noticeable effects from CBD, but keep in mind that it’s best to start small, especially if you’re new to CBD.

And always talk with a healthcare professional before adding a supplement like CBD to your routine.