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You probably already know that once lost, tooth enamel can’t be replaced. You may not know, however, that using a remineralizing toothpaste can increase the mineral content of existing tooth enamel.

Remineralization helps strengthen the entire tooth. It also repairs weak spots and makes teeth less sensitive to hot and cold. In order to get the best results, it’s important to choose the right product.

Healthline’s dental experts chose the remineralizing toothpastes featured in this article.

These products have undergone clinical trials or contain active ingredients that have been scientifically proven to strengthen tooth enamel and rejuvenate mineral content.

They all come from trusted manufacturers and have high customer ratings for taste and ease of use.

Pricing guide

  • $ = under $5
  • $$ = $5–$9
  • $$$ = over $9

There are many effective remineralizing toothpastes. Here are three to consider.

Best anti-cavity remineralizing toothpaste

3M Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste

Price: $$$

You and your dentist may decide that a prescription toothpaste such as 3M Clinpro 5000, which contains more fluoride than traditional toothpaste brands, may be the best choice for you.

A study reported in the Journal of Conservative Dentistry found that Clinpro 5000 is more effective at remineralizing teeth than several commercially sold brands.

The active ingredients in this low-abrasive toothpaste are sodium fluoride and tri-calcium phosphate. It works to remineralize lesions that exist throughout teeth, as well as those on surface enamel.

Even though it’s stronger than traditional toothpaste brands, Clinpro 5000 is not harsh or bitter tasting. You can request it in one of three flavors: vanilla mint, bubblegum, or spearmint.

Best remineralizing toothpaste for sensitive teeth

Sensodyne Pronamel

Price: $$

The Sensodyne brand is known for its ability to make teeth less sensitive to hot and cold. The active ingredients in Sensodyne Pronamel are potassium nitrate and sodium fluoride.

A study from The Journal of Clinical Dentistry found that Sensodyne Pronamel and Sensodyne Pronamel Gentle Whitening were both highly effective at remineralizing teeth. It also found that these toothpastes offered very good anti-erosion protection.

Best overall remineralizing toothpaste

Crest Pro-Health Advanced

Price: $

This Crest toothpaste formulation has the ADA Seal of Acceptance for controlling enamel erosion, gingivitis, and plaque, and for anti-sensitivity. Its active ingredient is stannous fluoride.

Studies show that this ingredient has been consistently shown to be more effective than sodium fluoride at remineralizing teeth and preventing cavities.

This is an effective, affordable alternative to other remineralizing toothpastes.

The most effective remineralizing toothpastes contain ingredients such as:

  • stannous fluoride
  • sodium fluoride
  • calcium phosphate (hydroxyapatite)

These ingredients are able to bond to weakened tooth enamel, forming patches, much like patches sewn into worn-out fabric.

Even though these patches aren’t made from tooth enamel, they have the ability to strengthen and protect teeth.

Remineralizing toothpastes also help prevent additional tooth decay from occurring, especially when they’re combined with proactive oral care habits, such as brushing and flossing after meals.

What else helps?

Lifestyle and dietary choices, such as avoiding sugary substances like soda and candy, greatly impact the ability of teeth to remineralize and affect overall tooth health.

Calcium is one mineral that helps keep tooth enamel strong. Not enough calcium in teeth can sometimes be connected to a calcium deficiency.

If you are postmenopausal or have a condition such as hypocalcemia, your body might pull calcium from your teeth in order to support other vital functions.

Talk with your doctor about treatments that might help.

Ask a dentist

Talk with your dentist about remineralizing toothpastes and your specific needs.

In some instances, your dentist may recommend a prescription remineralizing toothpaste.

These typically have a higher fluoride content and may be designed to penetrate into the tooth’s root as well as into the enamel.

Look for the ADA seal

It’s good to choose a toothpaste with the American Dental Association’s (ADA) Seal of Acceptance. The seal indicates when a dental product has met ADA standards for safety and effectiveness.

You can always ask your dentist for their opinion on any product without the seal. You can even contact the company that makes the toothpaste to ask why it hasn’t received the seal.

Read the ingredients

Every toothpaste lists its active and inactive ingredients. Make sure to check the inactive ingredients to determine if you’re sensitive or allergic to them.

Potential allergens or irritants in toothpaste can include flavorings such as:

  • mint
  • cinnamon
  • grape
  • orange

Allergic reactions have also been linked to ingredients such as:

  • cocamidopropyl betaine (CAPB)
  • propylene glycol

Know the brand

Look for a reputable brand name as well as transparency about the ingredients the product contains and the place where it’s manufactured.

Any product that promises to rebuild tooth enamel or that makes claims that seem too good to be true should probably be avoided.

Tooth enamel can’t be regenerated, but the mineral content within teeth can be increased.

Remineralizing toothpaste formulas, when combined with proper oral health and dietary choices, can help teeth become stronger, more comfortable, and less susceptible to cavities.