What is primary hyperparathyroidism?
The parathyroid glands are four small glands located near or on the back of the thyroid gland below the Adam’s apple. (Yes, women do have an Adam’s apple. It’s just smaller than a man’s.) These glands produce parathyroid hormone (PTH).
The parathyroid glands control the levels of calcium, phosphorus, and vitamin D in the body. The main trigger for the release or production of PTH is the level of calcium in the blood. PTH helps regulate the amount of calcium in the body. If your calcium level becomes too low, PTH helps bring more calcium into your blood. It does this by increasing the reabsorption of calcium from the intestines and from the bones. PTH also reduces the amount of calcium lost in urine.
Your parathyroid glands are normally very small. They’re generally about the size of a single grain of rice. Sometimes, one or more of the glands becomes enlarged. It then produces too much PTH. In other cases, a growth on one of these glands can cause it to produce increased amounts of PTH.
Too much PTH leads to too much calcium in your blood. This condition is called hypercalcemia. It can cause a variety of symptoms, including:
- frequent urination
- stomach problems
Primary hyperparathyroidism often has no symptoms. If symptoms are present, they’re usually very mild. Primary hyperparathyroidism is especially found in postmenopausal women, according to research published in the International Journal of Endocrinology. High blood pressure often accompanies hyperparathyroidism. When you treat your hyperparathyroidism, your blood pressure will likely come down.
Symptoms that occur with hyperparathyroidism are often nonspecific. This means they’re not exclusive to this condition. For example, you might experience:
If your condition is more severe, you might also experience:
- kidney stones, due to
increased calcium levels
- frequent urination
- abdominal, or stomach, pain
- nausea and vomiting
- impaired memory
- personality changes
- bone thinning and fractures
- coma (in rare cases)
Primary hyperparathyroidism occurs when your parathyroid glands produce too much PTH. A variety of conditions can result in hyperparathyroidism, such as the following.
An adenoma is a noncancerous tumor on one of these glands. These tumors are the most common cause of primary hyperparathyroidism.
Parathyroid gland enlargement
In other cases, enlargement of at least two of your parathyroid glands can lead to hyperparathyroidism. Doctors often don’t know what causes this enlargement.
In rare cases, parathyroid cancer may cause enlargement of one or more of the parathyroid glands. These tumors can cause hyperparathyroidism.
Primary hyperparathyroidism is generally diagnosed through blood tests. Signs of this condition include:
- elevated PTH
- elevated blood calcium
- elevated alkaline phosphatase, a protein found in bone and liver
- low levels of phosphorus
When your doctor suspects hyperparathyroidism, they’ll probably check your bone density. Having too much PTH raises the levels of calcium in your blood. Your body draws this calcium from your bones. X-rays can help your doctor identify bone problems, such as fractures and thinning.
The severity of primary hyperparathyroidism can vary greatly. There is no single course of treatment suitable for all cases. Your doctor will work with you to figure out what’s best for your individual case.
If you don’t have any symptoms, you may not need immediate treatment. Instead, your doctor might simply monitor your condition to make sure it doesn’t get worse. They may monitor:
- calcium levels
- kidney function
- bone density
- whether you’ve begun to develop kidney stones
If you do need treatment, surgery is the most common treatment option and leads to a cure in almost all cases. Only the glands that are affected are removed. If all four glands are enlarged, a portion of one of the glands will be left in the body so you’ll still have parathyroid tissue that is functioning.
Your doctor might suggest surgery if:
- your calcium level is more than 1.0 milligram per deciliter (mg/dL) above the normal range of 8.5–10.2 mg/dL, even without symptoms
- your bone density is too low
- you have symptoms related to a high calcium level
- you’re under 50 years of age
Sometimes medications are recommended to help prevent some of the complications associated with primary hyperparathyroidism. For instance:
- Bisphosphonates, such as alendronate (Fosamax), help decrease bone turnover.
- Cinacalcet (Sensipar) helps normalize calcium levels in the blood.
Estrogen therapy may be prescribed for postmenopausal women.
Hyperparathyroidism is a condition when your parathyroid glands produce too much parathyroid hormone in your body. This causes your calcium levels to rise, which can lead to bone thinning and fractures, abdominal problems, and depression. Often there are no early symptoms. If treatment is medically necessary, surgery is recommended and is most often curative.