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Terbutaline and Its Use in Preterm Labor

Terbutaline for preterm labor

Highlights

  1. Terbutaline is a type of medication used to stop contractions and delay the labor process.
  2. It may be injected into the skin or given through a vein in the arm.
  3. Terbutaline may be effective in delaying preterm labor for several hours or days.

A healthy, normal pregnancy lasts 40 weeks. We do not want women to deliver before 40 weeks, as the risk to the baby is great. While most pregnant women go into labor at the 40-week mark, some women go into labor earlier. Preterm labor happens before the 37th week of pregnancy and is characterized by uterine contractions that begin to open the cervix.

If preterm labor isn’t stopped, the baby will be born early, or prematurely. Premature babies often need additional care after birth. They sometimes have long-term health problems that can affect their entire lives. The earlier in pregnancy a baby is born, the more likely they are to have complications, the most serious of which is not being able to breathe on their own.

Doctors may try to stop or delay preterm labor by administering a medication called terbutaline (Brethine). Terbutaline is in a class of drugs called betamimetics. They help prevent and slow contractions of the uterus. It may help delay birth for several hours or days. During that period, doctors can administer other drugs to help ensure the baby is born as healthy as possible. One of those drugs is given to the mother to help the baby’s lungs mature faster. These drugs need 12 to 72 hours to begin to work. Using terbutaline delays delivery for several days (at least) and allows time for the drugs to work.

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Administration

How is terbutaline administered?

Terbutaline can be given subcutaneously, which means injected into the skin, or intravenously (IV), which means given through a vein. The usual dose of terbutaline is 0.25 milligrams (mg). It’s usually injected into the shoulder or given through a vein in the arm. If there isn’t a significant decrease in contractions within 15 to 30 minutes, a second dose of 0.25 mg may be administered. If the second dose isn’t effective, other treatments will be considered. The total dose of terbutaline shouldn’t exceed 0.5 mg, and the medication shouldn’t be used for more than two days at a time.

Guidelines recommend treating the mother for 48 to 72 hours then discontinuing treatment. Stopping delivery for two to three days gives a little more time for the baby to mature and for the drugs to help the baby’s lungs work take effect.

Terbutaline was prescribed as an oral medication in past years, but this form of the drug was discontinued due to dangerous side effects and safety concerns. Oral terbutaline should no longer be taken.

Long term (more than 72 hours) of terbutaline is no longer recommended. Continual heart monitoring is standard practice. It’s also important to note that terbutaline should never be used outside of a hospital. The drug is only supposed to be administered in hospital settings with medical staff available.

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How it works

How does terbutaline work?

Terbutaline is derived from a hormone called epinephrine, which is released when someone is under stress. This response is part of the fight-or-flight response. Stress causes many of the muscles in the body to contract so that a person is ready to respond quickly. However, there are certain muscles that relax instead of contracting during times of stress. Smooth muscle is one type of muscle that relaxes when someone is under stress. Since most of a woman’s uterus is made up of smooth muscle, the uterus will relax in response to a drug that contains certain substances, such as epinephrine.

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Effectiveness

How effective is terbutaline?

Women respond differently to terbutaline, so its effects and how long they last vary from one woman to another. When you have a good response to terbutaline, the drug reduces the number and frequency of contractions. This can help delay delivery for several hours, depending on how quickly the medication is received.

Although this may not seem like a lot of time, when terbutaline is administered along with steroids, it can significantly lower the risk for health problems in the baby. After 48 hours, steroids can improve a baby's lung function and increase their chances of living, reduce their chances of long term health problems, and reduce their length of stay in a NICU (neonatal intensive care unit).

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Side effects

What are the possible side effects of terbutaline?

The use of terbutaline may be successful in treating preterm labor. However, it does come with some risks to the mother and the baby.

For the mother

Since terbutaline is related to hormones released in the fight-or-flight response, a woman may experience the same effects when taking terbutaline as she does when under stress. Many women experience:

A few women have more serious side effects, such as irregular heartbeats, extra fluid in the lungs (which is called pulmonary edema), and chest pain. The more serious side effects tend to occur when women are taking high doses, but the effects can also occur with standard doses. Terbutaline may also increase your risk of diabetes. In some cases, death has been reported.

For the baby

Terbutaline can cause a temporary increase in the baby’s heart rate and blood sugar levels. These side effects usually aren’t serious and are easy to treat after delivery if they occur. There are concerns about long term use of this drug because the incidence of danger to the baby increases.

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Considerations

Are there women who should not take terbutaline?

Women who have medical conditions that could be aggravated by the possible side effects of terbutaline shouldn’t take the drug. This includes women with heart conditions or hyperthyroidism, and poorly controlled diabetes.

What Is Off-Label Drug Use?
Off-label drug use means that a drug that’s been approved by the FDA for one purpose is used for a different purpose that has not been approved. However, a doctor can still use the drug for that purpose. This is because the FDA regulates the testing and approval of drugs, but not how doctors use drugs to treat their patients. So, your doctor can prescribe a drug however they think is best for your care.

The FDA issued an advisory in February of 2011 regarding the use of terbutaline in the treatment of preterm labor. This warning was specific to the “off-label” use of terbutaline to treat preterm labor. The warning says that the oral form of the drug should never be used to treat preterm labor because it doesn’t work and the side effects come with too high of a risk. It also warns that injectable terbutaline should only be used in urgent situations, and for no longer than 48 to 72 hours. Prolonged use of the medication greatly increases the risk for life-threatening heart problems in the mother.

It’s important to be aware of this warning, but specific situations may result in this drug being used by specialists for longer periods under close supervision. Talk to your doctor if you have any concerns.

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