Highlights for orphenadrine

  1. Orphenadrine oral tablet is only available as a generic drug. It doesn’t have a brand-name version.
  2. Orphenadrine comes in two forms: as an oral extended-release tablet and as intravenous (IV) and intramuscular (IM) injections. The injections are only given by a healthcare provider.
  3. Orphenadrine oral tablet is used to treat muscle pain from musculoskeletal conditions. It’s used with rest, physical therapy, and other treatments.

Important warnings

  • Lightheadedness warning: This drug may cause lightheadedness, dizziness, or loss of consciousness. These effects are due to a sudden drop in blood pressure. This drug can make it difficult for you to do activities that require alertness. You should not drive or use machinery until you know how this drug affects you.

What is orphenadrine?

This drug is a prescription drug. It comes as an extended-release oral tablet. An extended-release tablet releases the drug into your body slowly. This drug also comes as intravenous (IV) and intramuscular (IM) injections, which are only given by a healthcare provider.

Orphenadrine is only available as a generic drug.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

Orphenadrine is used to treat muscle pain from musculoskeletal conditions. It’s used with rest, physical therapy, and other treatments.

How it works

Orphenadrine belongs to a class of drugs called anticholinergic drugs. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It’s not fully understood how this drug works to relieve muscle pain. It may act on your brain to stop muscle spasms and pain.

Orphenadrine side effects

Orphenadrine oral tablet may cause drowsiness, and it can also cause other side effects.

More common side effects

The more common side effects of orphenadrine can include:

  • dry mouth
  • fast heart rate
  • trouble urinating
  • blurry vision
  • dilated pupils
  • higher blood pressure in your eyes
  • weakness
  • nausea
  • vomiting
  • headache
  • dizziness
  • constipation
  • drowsiness
  • itching, hives, or rash on your skin

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Nervous system side effects. Symptoms can include:
    • hallucinations (seeing or hearing things that aren’t there)
    • agitation
    • anxiousness
    • irritation
    • confusion
    • tremors
  • Anemia. Symptoms can include:
    • weakness
    • fast heart rate

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Orphenadrine may interact with other medications

Orphenadrine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with orphenadrine are listed below.

Increased side effects from orphenadrine

Taking orphenadrine with certain medications raises your risk of side effects from orphenadrine. This is because the amount of orphenadrine in your body may be increased. Examples of these drugs include:

  • Amantadine
  • Depression drugs such as bupropion and nortriptyline
  • Cyclobenzaprine
  • Antihistamines such as diphenhydramine and meclizine
  • Sleep drugs such as zaleplon and zolpidem
  • Tramadol
  • Diazepam

Increased side effects from other drugs

Taking orphenadrine with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:

  • Propoxyphene. Increased side effects can include confusion, anxiety, and tremors. If you have these side effects, your doctor may lower your dosage or stop your treatment with either drug.
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Orphenadrine warnings

This drug comes with several warnings.

Allergy warning

This drug can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

Drinking alcohol can increase your risk of drowsiness and dizziness from this drug. If you drink alcohol, talk to your doctor.

Warnings for people with certain health conditions

For people with heart problems: If you have heart failure, reduced blood flow to your heart, or a fast or irregular heart rate, ask your doctor if this drug is safe for you. This drug may make your condition worse.

For people with eye problems: This drug can increase the blood pressure in your eyes. You should not use this drug if you have glaucoma. It can make your glaucoma worse. Tell your doctor if you have a history of eye problems before taking this drug.

For people with stomach problems: You should not use this drug if you have certain kinds of ulcers or any blockage in your digestive tract. Tell your doctor if you have a history of stomach problems. Your doctor will decide if this drug is safe for you.

For people with prostate or bladder problems: You should not use this drug if you have an enlarged prostate or a blockage of your urinary bladder neck. Tell your doctor if you have a history of prostate or bladder problems. Your doctor will decide if this drug is safe for you.

For people with myasthenia gravis: You should not use this drug. It can make your condition worse.

Warnings for other groups

For pregnant women: This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect a pregnancy.

Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the pregnancy.

If you become pregnant while taking this drug, call your doctor right away.

For women who are breastfeeding: It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children: This medication has not been studied in children. It should not be used in children younger than 18 years.

How to take orphenadrine

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

The dosage information below is for the conditions that orphenadrine is most often prescribed to treat. This list may not contain all conditions that your doctor can prescribe this drug for. If you have questions about your prescription, talk with your doctor.

Dosage for muscle pain

Generic: Orphenadrine

  • Form: oral tablet
  • Strength: 100 mg

Adult dosage (ages 18 years and older)

  • Typical starting dosage: 200 mg per day. You’ll take one 100-mg tablet in the morning and one 100-mg tablet in the evening.

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in children younger than 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Take as directed

Orphenadrine oral tablet is used for short-term treatment. The safety of this drug for long-term treatment has not been established.

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your muscle pain may not get better.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • dry mouth
  • trouble urinating
  • blurry vision

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have less pain and stiffness.

Important considerations for taking orphenadrine

Keep these considerations in mind if your doctor prescribes orphenadrine for you.

General

  • You can take this drug with or without food.
  • Take this drug at the time(s) recommended by your doctor.
  • Do not crush or chew the tablet. Swallow the tablet whole.

Storage

  • Store this drug at room temperature. Keep it between 59°F and 86°F (15°C and 30°C).
  • Keep this drug away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t harm your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained here in is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.