Opioids, a type of prescription pain medication, can trigger a specific type of constipation known as opioid-induced constipation (OIC). Opioid drugs include painkillers such as:

  • oxycodone (OxyContin)
  • hydrocodone (Vicodin)
  • codeine
  • morphine

These medications are effective because they block pain signals by attaching to receptors throughout your nervous system. These receptors are also found in your bowels. When opioids attach to receptors in your gut, it lengthens the amount of time it takes stool to pass through your gastrointestinal system.

Constipation is defined as having fewer than three bowel movements a week. Anywhere from 41 to 81 percent of people who take opioids for chronic, non-cancer pain experience constipation. But there are medications and natural and home remedies that can help you find relief.

Over-the-counter (OTC)

  • Stool softener: These include docusate (Colace) and docusate calcium (Surfak). They increase the amount of water in your colon and help stools pass easier.
  • Stimulants: These include biscacodyl (Ducodyl, Dulcolax) and senna-sennosides (Senokot). These induce bowel activity by increasing intestinal contractions.
  • Osmotics: Osmotics are a type of medication that help fluid move through the colon. These include oral magnesium hydroxide (Phillips Milk of Magnesia) and polyethylene glycol (MiraLAX).

Learn more: Stool softeners vs. laxatives »

Mineral oil is a lubricant laxative that also helps stool move through the colon. It’s available as an OTC option in oral and rectal form. An enema or suppository inserted into the rectum may soften stools and stimulate bowel activity. There’s a risk of damaging the rectum if it’s inserted improperly.

Read more: How to use rectal suppositories »


Prescription medication specifically for OIC should treat the problem at its root. These medications stop opioids from attaching to receptors in the gut. Prescriptions approved for the treatment of OIC include:

  • naloxegol (Movantik)
  • methylnaltrexone (Relistor)
  • lubiprostone (Amitiza)

These prescription medications may cause side effects, such as:

  • nausea
  • vomiting
  • headache
  • diarrhea

Speak with your doctor if you experience side effects. It may help to modify your dosage or switch to a different medication.

Some supplements and herbs can relieve OIC by stimulating bowel activity. These include:

Fiber supplement

Fiber has a laxative effect because it increases water absorption in the colon. This forms bulkier stools and helps stools pass easier. Bulk-forming fiber supplements include psyllium (Metamucil) and methylcellulose (Citrucel).

But although fiber supplements are an effective remedy for constipation, more studies and research are needed to confirm the efficacy of fiber supplements for OIC. Fiber can be a treatment for this specific type of constipation, but it’s important to drink plenty of fluids while taking a fiber supplement. If you don’t drink enough fluids, dehydration can make OIC worse and cause fecal impaction.

You should eat between 25 to 30 grams of fiber per day. Take one to three tablespoons daily of Citrucel, or use Metamucil up to three times a day. Fiber supplements can decrease the absorption of some medications such as aspirin. Talk with your doctor before combining a fiber supplement with any prescription medications.

Learn more: The health benefits of psyllium »

Aloe vera

Aloe vera may also relieve OIC. In one study, rats were given an oral administration of loperamide to induce constipation. They were then treated with 50, 100, and 200 milligrams (mg) of an aloe vera extract for seven days. The study found that the rats receiving the extract had improved intestinal motility and fecal volume. Based on the study, the laxative effect of aloe vera may improve drug-induced constipation.

Consult a doctor or pharmacist before taking aloe vera. The herb may decrease the effectiveness of certain medications, such as cholesterol-lowering drugs, anti-inflammatories, and hormonal drugs.

Keep reading: 7 amazing uses for aloe vera »


Senna is a yellow flowering plant. Its leaves have a laxative effect, which can help naturally relieve OIC. A study of 22 people with OIC post-surgery found that senna improved constipation when taken daily for six days.

Senna supplements are available as capsules, tablets, and tea. You can buy dry senna leaves from a health foods store and brew them in hot water. Or, you can purchase sennosides tablets (Senokot) from a grocery or drugstore. Take 10 mg to 60 mg daily for 10 days. Children ages 6 and older should take half this dose.

Senna should be taken on a short-term basis. Long-term use can cause diarrhea and trigger an electrolyte imbalance. This herb may also increase the risk of bleeding when taken with certain medications. These medications include:

  • aspirin
  • blood thinners, like warfarin (Coumadin)
  • nonsteroidal anti-inflammatory medications (NSAIDs), like ibuprofen (Advil) and naproxen sodium (Aleve)

A few home remedies may also improve OIC or help you manage discomfort. Try these along with medications or natural remedies:

1. Increase physical activity. Exercise and physical activity stimulates contractions in the intestinal tract and promotes bowel activity. Aim for 30 minutes of exercise most days of the week. Talk with your doctor before starting a new exercise routine.

2. Drink plenty of fluid. Dehydration makes it difficult to have a bowel movement. Drink 8-10 glasses of fluid per day. Stick to water, tea, juices, or decaf coffee.

3. Eat more fiber. Increase fiber intake naturally to normalize bowel activity. Add fruits, vegetables, and whole grains to your diet. Excellent sources of fiber include:

  • prunes
  • raisins
  • apricots
  • asparagus
  • beans

Too much fiber can cause diarrhea and abdominal cramping, so slowly increase your intake.

4. Use ice or heat therapy. Constipation can cause bloating and abdominal pain. Apply a warm or cold compress to your pelvic area to relieve discomfort.

5. Eliminate trigger foods from your diet. Fatty and processed foods are difficult to digest and may make OIC worse. Limit your intake of trigger foods, such as fast foods and junk foods.

Although opioids can reduce your pain, there’s the risk of constipation while taking these medications. If lifestyle changes, home remedies, and OTC medicines don’t provide the desired results, talk to your doctor about prescriptions to help regulate bowel activity.