Nonallergic rhinitis with eosinophilia syndrome is a type of rhinitis where you have large numbers of immune cells called eosinophils in your nasal tissue but no symptoms of allergies. It can be treated with intranasal medications.
Rhinitis is a term that refers to inflammation in your nose. It can be classified as either allergic or nonallergic.
Allergic rhinitis is when your immune system reacts to factors in the environment, such as pollen, molds, and animal dander. This causes an allergic reaction.
Nonallergic rhinitis is nasal inflammation that occurs in the absence of an allergic reaction. Nonallergic rhinitis with eosinophilia syndrome (NARES) is a subtype of nonallergic rhinitis.
In the article below, we’ll dive into more detail about NARES. We’ll cover its symptoms, causes, how it’s diagnosed and treated, and more.
Eosinophils are a type of immune cell. When they’re activated, they can make a variety of factors that promote inflammation. Typically, eosinophils are involved in protecting your body from infections, especially those due to parasites.
People with NARES have high levels of eosinophils in their nasal tissue. However, they have no evidence of an existing allergy or other nasal conditions that could be causing their symptoms.
The symptoms of NARES include:
NARES and several other types of nonallergic rhinitis are chronic, meaning that symptoms last for 3 months or longer.
People with NARES may also have
The symptoms of NARES are believed to be caused by the movement of eosinophils into nasal tissue.
What exactly triggers NARES is unknown. The researchers of a
People with NARES don’t have any evidence of allergies. As such, allergy testing comes back negative.
A doctor may also take a sample of nasal secretions or tissue to check for the presence of certain immune cells.
People with NARES have increased eosinophils and mast cells. There may also be evidence of mast cell degranulation, which is the process by which mast cells release histamine and other factors.
There are several medications that may be used alone or in combination to treat NARES. These are typically given intranasally and include:
- corticosteroids, drugs that reduce inflammation
- antihistamines, drugs that help to block the activity of histamine
- leukotriene inhibitors, drugs that block the activity of leukotrienes, inflammatory factors made by immune cells
like eosinophils and mast cells
Some people with NARES may also find that nasal irrigation with a saline rinse may provide some relief. A
Can allergic rhinitis cause high eosinophil levels?
What are other types of nonallergic rhinitis?
In addition to NARES, there are several other types of nonallergic rhinitis. A few examples are:
- drug-induced rhinitis, which is when rhinitis comes on due to drugs like NSAIDs, some blood pressure drugs, and certain other anti-inflammatory drugs
- hormone-related rhinitis, such as rhinitis in pregnancy
- gustatory rhinitis, which typically comes on after eating hot or spicy foods
- occupational rhinitis due to environmental exposures in the workplace
- infectious rhinitis, such as that caused by colds, the flu, and COVID-19
Are there other conditions associated with high levels of eosinophils?
High levels of eosinophils may be present in many different health conditions. Some examples include:
NARES is a type of rhinitis where there are high levels of eosinophils in your nasal tissue. People with NARES have no markers of allergies or other nasal conditions that may be causing their symptoms.
A variety of intranasal medications may be used to help manage the symptoms of NARES. These include things like steroids and antihistamines.
If you’ve had sneezing, runny nose, or reduced sense of smell for a prolonged period of time, see your doctor. They can do tests to determine what may be causing your symptoms and develop a plan to help you manage them.