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Nabumetone, Oral Tablet

Highlights for nabumetone

  1. Nabumetone oral tablet is only available as a generic drug.
  2. Nabumetone may cause serious side effects, including blood clots, heart attack, stroke, ulcers, and bleeding.
  3. Nabumetone is used to help reduce pain, inflammation, and swelling caused by osteoarthritis and rheumatoid arthritis.
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Important warnings

Important warnings

FDA warnings
  • Nabumetone has a black box warning. This is the most serious warning from the U.S. Food and Drug Administration (FDA). Though the medication can still be sold and used, a black box warning alerts doctors and patients to potentially dangerous problems.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as nabumetone, may increase risk of blood clots, heart attack, or stroke. People with a history of heart disease or who have risk factors for heart disease, such as high blood pressure, are at increased risk. Your risk may also be higher if you take this medication for a long time or at high doses.
  • This drug shouldn’t be used to control pain in patients with recent heart bypass surgery.
  • Nabumetone may increase risk of ulcers or bleeding from the stomach or intestines. Sometimes, patients won't have any signs or symptoms of bleeding. Older adults have a higher risk of ulcers, bleeding, or both.
  • Ulcers or bleeding from stomach or intestines warning: Nabumetone may increase your risk of ulcers or bleeding from the stomach or intestines. It should be used with extreme caution in people with a history of ulcers or bleeding.
  • May increase the risk of Heart attack, stroke, and high blood pressure warning: Nabumetone may increase the risk of heart attack, stroke, and high blood pressure. It should be used with caution in people with a history of heart disease or those at risk of heart disease.
  • Fluid retention and worsened heart failure warning: Nabumetone may increase fluid retention and worsen heart failure.
  • Sudden allergic reaction warning: Nabumetone may cause a sudden allergic reaction, but this is very rare. If you have difficulty breathing, seek immediate medical care or call 911 right away. If you have had an allergic reaction to aspirin or other non-steroidal anti-inflammatory drugs, you may have an increased risk of this reaction.
  • Worsened asthma symptoms warning: May increase the risk of worsened asthma symptoms in people with asthma.

About

What is nabumetone?

Nabumetone oral tablet is a prescription drug that’s only available as a generic drug.

Why it's used

Nabumetone is used to reduce pain, inflammation, and swelling in people with osteoarthritis or rheumatoid arthritis.

How it works

Nabumetone belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). A class of drugs refers to medications that work similarly in your body. They have a similar chemical structure and are often used to treat similar conditions.

NSAIDs block the production of chemicals in your body that cause inflammation and pain.

NSAIDs help to manage the symptoms of pain, stiffness, inflammation, and swelling caused by osteoarthritis and rheumatoid arthritis.

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Side effects

Nabumetone side effects

Nabumetone oral tablet doesn’t cause drowsiness. However, it can cause other side effects.

More common side effects

Most people don’t experience many uncomfortable side effects from nabumetone. However, side effects are possible. The more common side effects that occur with nabumetone include:

  • headache
  • dizziness
  • nausea
  • stomach pain
  • constipation
  • swelling of the hands, feet, and ankles
  • mild rash
  • ringing in the ears
  • sensitivity to the sun

Serious side effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening, or if you think you’re experiencing a medical emergency, call 911. Serious side effects of nabumetone include:

  • severe chest pain, which could be the sign of a heart attack
  • bleeding from the stomach or intestines
  • severe stomach pain, which could be caused by ulcers in the stomach or intestines
  • signs of stroke, including difficulty speaking or thinking, weakness on one side of the body, and blurred vision
  • cramping or pain in legs or coughing and difficulty breathing, which could be signs of a blood clot
  • high blood pressure
  • symptoms of heart failure or kidney toxicity, including weakness, coughing, and swelling or unusual weight gain
  • signs of liver toxicity, including abdominal cramping or pain, and yellowing of eyes or skin
  • sudden or severe rash
  • symptoms of severe allergic reaction, such as sudden difficulty breathing

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Interactions

Nabumetone may interact with other medications

Nabumetone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with nabumetone are listed below.

Anti-inflammatory drug

  • ketorolac

Do not take nabumetone and ketorolac together.

Chemotherapy drug

  • omacetaxine

Do not take nabumetone and omacetaxine together.

ACE Inhibitors

Nabumetone and other NSAIDs may decrease the blood pressure-lowering effects of ACE inhibitors. ACE inhibitors are used to relax blood vessels and lower blood pressure. Examples of ACE Inhibitors include:

  • captopril (Capoten)
  • enalapril (Vasotec)
  • lisinopril (Prinivil/Zestril)

Diuretics

Nabumetone can lessen the effects of diuretic drugs. These include:

  • thiazide diuretics (chlorothiazide, hydrochlorothiazide)
  • furosemide (Lasix)

Methotrexate

Nabumetone can increase the toxicity of methotrexate. Methotrexate is commonly used to treat rheumatoid arthritis. Its toxic effects can include changes in your blood and your ability to fight infections.

Lithium

Lithium levels can become increased when taking nabumetone. Nabumetone makes lithium leave your body more slowly, so the level can increase over time.

Warfarin, Aspirin, and Other NSAIDs (ibuprofen, naproxen, celecoxib)

These drugs can increase side effects of nabumetone (particularly risk of ulcer and bleeding). They are not recommended for use during nabumetone therapy.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

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Other warnings

Nabumetone warnings

Nabumetone oral tablet comes with several warnings.

Allergy warning

People who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) shouldn’t take this drug. If you’re not certain about your allergy risk, talk to your doctor or pharmacist.

Warnings for people with certain health conditions

For people with ulcers or gastrointestinal bleeding: Nabumetone may increase risk of ulcers or bleeding from the stomach or intestines. The drug should be used with extreme caution in people with a history of ulcers or bleeding.

For people with heart disease: Nabumetone can increase the risk of heart attack, stroke, and high blood pressure. It should be used with caution in people with a history of heart disease or those at risk of heart disease. Risk factors for heart disease include:

  • high blood pressure
  • high cholesterol
  • diabetes
  • cigarette smoking
  • family history of heart disease
  • obesity
  • being a postmenopausal woman. The risk of heart disease increases after menopause.

For people with heart failure: Nabumetone can increase fluid retention and worsen heart failure.

For people with asthma: People with asthma sometimes have an increased risk of allergic reactions to nabumetone.

Warnings for other groups

For pregnant women: Nabumetone is a pregnancy category C drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans.

Nabumetone shouldn’t be used during pregnancy, especially in late stage pregnancy. If you’re pregnant and need treatment for rheumatoid arthritis or osteoarthritis, talk to your healthcare provider about your treatment options.

Women who are breastfeeding: It’s not known if this drug passes into breast milk. Talk to your healthcare provider about whether you should continue breastfeeding while taking this drug.

For seniors: If you’re an older adult, you may be more likely to have stomach upset or bleeding.

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Dosage

How to take nabumetone

This dosage information is for nabumetone oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Forms and strengths

Generic: nabumetone

  • Form: oral tablet
  • Strength: 500 mg, 750 mg

Dosage for osteoarthritis

Adult dosage (ages 18-64 years)

Nabumetone is often started at 1000 mg per day. It may be taken once a day or in two divided doses. The dose is gradually adjusted if needed.

Child dosage (ages 0-17 years)

This medicine has not been studied in children and should not be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Dosage for rheumatoid arthritis

Adult dosage (ages 18-64 years)

Nabumetone is often started at 1000 mg per day. It may be taken once a day or in two divided doses. The dose is gradually adjusted if needed.

Child dosage (ages 0-17 years)

This medicine has not been studied in children and should not be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Special considerations

People with kidney disease generally shouldn’t use this drug. Kidney disease can affect the way the drug is processed in the body. Speak with your healthcare provider about your treatment with nabumetone if you have kidney disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

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Take as directed

Take as directed

Nabumetone oral tablet comes with serious risks if you don’t take it as prescribed.

If you don’t take it or stop taking it: If you have osteoarthritis or rheumatoid arthritis and don’t take your nabumetone, you risk:

  • increasing inflammation and swelling in your joints
  • decreasing ability to control your pain

If you don’t take it on schedule: Not taking nabumetone every day, skipping days, or taking doses at different times of day may increase your risk for inflammation or decreased control of your pain.

If you miss a dose: If you miss a dose, just take the next dose as scheduled. Don’t double your dose.

How can I tell if the drug is working?: You can tell this drug is working if your arthritis pain and swelling is controlled while taking it.

Important considerations

Important considerations for taking nabumetone

Keep these considerations in mind if your doctor prescribes nabumetone oral tablet for you.

General

Though you don’t have to, taking nabumetone with food may decrease possible nausea. The tablet is film coated and shouldn’t be cut, crushed, or chewed.

Storage

  • Store at 68 – 77°F (20 – 25°C).
  • Keep the medication tightly closed and in a light-resistant container.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

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Alternatives

Are there any alternatives?

Medications similar to nabumetone oral tablet are:

  • ibuprofen
  • naproxen
  • meloxicam
  • celecoxib
  • ketoprofen
  • oxaprozin
  • piroxicam
  • etodolac
  • diclofenac
  • aspirin

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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