Multiple sclerosis is a condition of the central nervous system, which includes the brain, spinal cord, and optic nerve. This can result in both physical and cognitive symptoms.

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Read on to learn how multiple sclerosis (MS) affects the brain.

Nerves communicate with each other and with the rest of the body by sending electrical and chemical signals.

To understand how your nerves work, think about how they’re similar to electrical cables. Nerves consist of a “wire,” which we call the axon. The axon is covered by an insulating material called myelin.

MS damages the myelin so that the nerve’s ability to conduct electrical signals is slowed and uncoordinated. If the axon is also damaged, the electrical signal may be blocked entirely.

When myelin damage happens, the nerve can’t send appropriate information. This produces symptoms.

For example:

  • If there’s a loss of myelin in the area of the brain that controls movement, there’s weakness.
  • If the part of the brain that’s responsible for coordination is damaged, this can cause tremors or loss of balance.
  • Lesions, or areas of nerve damage in the optic nerve, may result in vision loss.
  • Spinal cord damage is usually associated with decreased mobility, impaired or abnormal sensations, and impaired genitourinary (genital and urinary) function.

Changes due to MS can contribute to fatigue and other symptoms. Brain lesions can produce difficulty with thinking and memory. MS brain changes may also contribute to mood disorders such as depression.

MS is widely believed to be an autoimmune process. In other words, the immune system, which normally protects your body, goes “rogue” and begins to attack parts of your body.

In MS, the immune system attacks myelin surrounding the nerves in the CNS.

The Food and Drug Administration (FDA) has approved more than 20 different medications — known as disease-modifying therapies (DMTs) — that can limit the number of new lesions due to MS.

The most important strategies that have been documented for reducing future nerve damage are early diagnosis and timely treatment with these medications.

Lifestyle habits such as exercising regularly, not smoking, and maintaining a moderate body weight are also important.

MS produces damage in the more heavily myelinated regions of the brain, known as white matter. MS has also been shown to affect the less myelinated regions closer to the brain’s surface, known as cortical gray matter.

Damage to both white matter and gray matter structures is linked to cognitive impairment. Damage to specific brain regions can produce difficulty with specific cognitive skills like language, calculations, memory, or attention.

Brain atrophy, or shrinkage, in people with MS, involves faster deterioration of brain cells than the rate of brain atrophy in people of similar ages who don’t have MS.

This is because MS causes the destruction of axons as well as damage to the brain’s white and gray matter.

People with MS who smoke tobacco have been reported to have more brain atrophy than nonsmokers. Some studies have reported that certain DMTs may reduce the rate of brain atrophy.

There are also reports that people with MS who are more physically active have less atrophy than people who are less physically active.

The cognitive difficulties that are most common in people with MS tend to be related to memory and speed of information processing.

There may also be problems with:

  • multitasking
  • sustained memory and concentration
  • prioritizing
  • decision making
  • organization

Additionally, difficulty with verbal fluency, especially word finding — the feeling that “the word is on the tip of my tongue” — is common.

Cognitive difficulties may be a direct result of lesions. Cognition may also be impaired by one or more of these contributing factors:

  • fatigue
  • poor sleep
  • depression
  • the effects of medication

Some cognitive functions are more likely than others to remain unaffected or minimally affected by MS. General intelligence information and understanding of words tend to be preserved.

The presentation of MS can vary depending on the location of the lesions, which typically develop in areas such as the brain stem, cerebellum, spinal cord, optic nerves, and surrounding white matter.

So-called executive functions — such as multitasking, prioritizing, and decision-making — are most associated with the frontal lobes of the brain.

Many memory functions occur in a gray matter structure called the hippocampus. Its name comes from the Greek word for seahorse because this structure is shaped like a seahorse.

Damage to the corpus callosum, a very heavily myelinated bundle of nerves that connects the two hemispheres of the brain, is also associated with cognitive impairment.

MS commonly affects all of these areas.

Overall, brain atrophy and loss of brain volume are also highly correlated with cognitive function issues.

There are short tests of specific cognitive functions that can be easily and quickly administered in a doctor’s office. These can help screen for evidence of cognitive impairment. For example, one such test is called the Symbol Digit Modalities Test (SDMT).

If you have symptoms of cognitive decline or if a screening test suggests cognitive problems, your doctor may recommend a more in-depth assessment. This would usually be formally done with tests that are collectively referred to as neuropsychological testing.

It’s recommended that people with MS be assessed for cognitive function at least once per year.

When it comes to cognitive impairment in people with MS, doctors look for contributing factors, such as fatigue or depression, that may worsen cognitive problems.

For example, people with MS are at a higher risk of sleep apnea, which can also affect cognition. When such secondary factors are treated, cognitive function often improves.

Research has shown that targeted cognitive rehabilitation strategies are beneficial. These strategies address specific domains — such as attention, multitasking, processing speed, or memory — using techniques such as computer training.

A growing body of literature suggests that regular physical exercise may improve cognitive function in people with MS.

While no diet has been shown to affect cognition in people with MS per se, a heart-healthy diet may reduce the risk of comorbidities (other diseases) that can contribute to cognitive impairment.

A heart-healthy diet is generally one that primarily contains lots of fruits and vegetables, lean proteins, and “good” fats such as olive oil. The diet should also limit saturated fats and refined sugars.

Following this type of eating plan may limit comorbidities such as vascular disease, type 2 diabetes, or high blood pressure. All of these conditions can contribute to cognitive impairment and disability in people with MS.

Smoking is a risk factor for brain atrophy, so quitting smoking may help to limit further atrophy.

It’s also important to stay mentally active and socially connected.

These days, most people living with MS can manage their disease and can live as long as people without it.

According to a 60-year longitudinal study published in 2017, the general median life expectancy for all subjects with MS was about 74.7 years compared to 81.8 in people without MS. Men with MS had a median life expectancy of 72.2 years compared to 77.2 in women.

From the time of disease onset, people with MS lived an average of 40.6 years compared to 54.6 years for people without MS. Men lived for 35.7 years compared to 42.6 in women.

There’s no cure for MS. That said, early diagnosis and treatment can help slow the progression and manage your symptoms. Treatments include:

  • injectable medications such as beta-interferons
  • oral medications such as cladribine (Mavenclad) or fingolimod (Gilenya)
  • infusions such as ocrelizumab (Ocrevus) or natalizumab (Tysabri)

Learn more about the treatment options for MS.

You cannot diagnose yourself with MS. Only a doctor can determine whether you have the condition. That said, see your doctor if you experience the following symptoms, especially if you have a few of them simultaneously.

  • fatigue or weakness
  • walking problems
  • squeezing sensation around your torso
  • muscle stiffness or contractions
  • vision problems
  • bladder, bowel, or sexual difficulties
  • pain
  • itching
  • emotional or cognitive changes

Editor’s note: This article was originally published on June 12, 2019. Its current publication date reflects a medical review.

Barbara S. Giesser, MD received her medical degree from the University of Texas Health Science Center at San Antonio, and completed neurology residency training and MS fellowship at the Montefiore Medical Center (NY) and Albert Einstein College of Medicine. She’s specialized in the care of persons with MS since 1982. She’s currently Professor of Clinical Neurology at the David Geffen UCLA School of Medicine and Clinical Director of the UCLA MS program.

Dr. Giesser has conducted peer-reviewed research into the effects of exercise in persons with MS. She’s also created educational curricula for national organizations such as the National MS Society and the American Academy of Neurology. She’s active in advocacy efforts to promote access to care and medications for persons with MS and other neurologic diseases.