Multiple myeloma is a cancer of the plasma cells that causes a buildup of a harmful chemical in the body. As it progresses, the cancer can cause symptoms such as low blood counts, kidney issues, more frequent infections, and bone and calcium problems.
Though researchers are still not certain what causes multiple myeloma, they do know
Racial and ethnic background are considered contributing factors in the context that healthcare inequities may likely be the cause.
There are a lot of questions surrounding genetics and multiple myeloma. Here is what the latest research has to say about some of the most frequently asked questions about the cancer.
Researchers are looking into the genetic links of multiple myeloma. If they can understand how it affects people and the underlying cause, it will help them be better able to predict and treat the condition.
According to the Patient Empowerment Network, genetic mutations play a role in the development of multiple myeloma.
Chromosomal translocations (where parts of chromosomes are swapped) account for about 40 percent of all cases. In about 50 percent of cases, chromosome 13 is missing. In addition, there are at least 12 different genetic subtypes of myeloma.
Research published in 2014 states that cases of multiple myeloma can be divided into two broad groups based on the changes in the chromosomes. The two groups include:
- hyperdiploid group, which is characterized by trisomies (where there is an extra chromosome)
- nonhyperdiploid group, which is characterized by translocations (where parts of the chromosomes are swapped with other parts)
The researchers also noted that genetic events or changes contribute to the development of the cancer.
They noted that future studies should continue to look at biomarkers to determine the best course of treatment based on the cancer’s genetic makeup.
In some cases, multiple myeloma can run in families. But according to the American Cancer Society (ACS), this is not necessarily true for all cases. It is possible you or a loved one could develop multiple myeloma even if no one else in your family has the condition.
About 5 to 7 percent of cases occur in people with a family history of multiple myeloma.
If a close family member has developed multiple myeloma, you should let your doctor know. If your doctor is aware of the potential risk, they can look for early signs of the cancer and potentially start treatments earlier.
There are several potential risk factors for developing multiple myeloma.
Research demonstrates that multiple myeloma is more than twice as likely to occur in Black people compared with white people.
People assigned male at birth are also slightly more likely than people assigned female at birth to develop the cancer.
People living with another cancer or disease risk may also be more likely to develop multiple myeloma. For example, a
According to the ACS, other risk factors include having obesity or the presence of other plasma disorders.
Though the exact cause of multiple myeloma remains unknown, researchers have identified potential triggers to be aware of.
According to the International Myeloma Foundation, certain toxic chemicals and viruses may trigger the cancer. Some of the identified toxins include:
- engine exhaust
- cleaning products
- agricultural chemicals
Viral triggers can include:
- hepatitis B or C
- simian virus 40 (SV40), a contaminant in an early version of the polio vaccine
- several herpes viruses
Multiple myeloma can be terminal. How well you respond to treatment can vary based on factors such as age and overall health.
According to the ACS, the 5-year survival rate for multiple myeloma is:
- localized (has not spread): 75 percent
- distant (spread to other areas of the body): 53 percent
In other words, 75 percent of people diagnosed with localized multiple myeloma are still alive after 5 years. Your chances of survival depend on:
- when the cancer was caught
- your overall health
- your response to treatment
- your age
Treatment for multiple myeloma can vary based on the type of cancer you have. You should talk with your doctor about the best treatment options for you or your loved one. Treatment options can include:
- stem cell transplant
Multiple myeloma has a genetic link that can make it more likely to occur if your family has a history of the condition, and it’s diagnosed at a higher rate in people assigned male at birth.
Exposure to toxins or viruses, such as HIV, can trigger the cancer.
Your outlook depends on what stage the cancer is in when treatment begins, your overall health, and your response to treatment.
If you have questions about multiple myeloma or believe you or your loved one is at risk for the condition, talk with a healthcare professional.