The mitral valve is located in the left side of your heart between two chambers: the left atrium and the left ventricle. The valve works to keep blood flowing properly in one direction from the left atrium to the left ventricle. It also prevents blood from flowing backward.

Mitral valve disease occurs when the mitral valve doesn’t work properly, allowing blood to flow backward into the left atrium. As a result, your heart does not pump enough blood out of the left ventricular chamber to supply your body with oxygen-filled blood. This can cause symptoms such as fatigue and shortness of breath. However, many people with mitral valve disease experience no symptoms.

If left untreated, mitral valve disease can lead to serious, life-threatening complications such as heart failure or irregular heartbeats, called arrhythmias.

There are three types of mitral valve disease: stenosis, prolapse, and regurgitation.

Mitral valve stenosis

Stenosis occurs when the valve opening becomes narrow. This means that not enough blood can pass into your left ventricle.

Mitral valve prolapse

Prolapse occurs when the flaps on the valve bulge instead of closing tightly. This might prevent the valve from closing completely, and regurgitation — the backward flow of blood — may occur.

Mitral valve regurgitation

Regurgitation occurs when blood leaks from the valve and flows backward into your left atrium when the left ventricle compresses.

Each form of mitral valve disease has its own set of causes.

Mitral valve stenosis

Mitral valve stenosis is typically caused by scarring from rheumatic fever. Usually a childhood disease, rheumatic fever results from the body’s immune response to a streptococcal bacterial infection. Rheumatic fever is a serious complication of strep throat or scarlet fever.

The organs most affected by acute rheumatic fever are the joints and the heart. The joints can become inflamed, which can lead to temporary and sometimes chronic disability. Various parts of the heart can become inflamed and lead to these potentially serious heart conditions, including:

If the mitral valve becomes inflamed or otherwise injured by these conditions, it can lead to the chronic heart condition called rheumatic heart disease. The clinical signs and symptoms of this condition might not occur until 5 to 10 years after the episode of rheumatic fever.

Mitral stenosis is uncommon in the United States and other developed countries where rheumatic fever is rare. This is because people in developed countries generally have access to antibiotics that treat bacterial infections such as strep throat, according to the Merck Manual Home Health Handbook. Most cases of mitral stenosis in the United States are in older adults who had rheumatic fever before the widespread use of antibiotics or in people who have moved from countries where rheumatic fever is common.

There are other causes of mitral valve stenosis, but these are rare. They include:

Mitral valve prolapse

Mitral valve prolapse often has no specific or known cause. It tends to run in families or occur in those who have other conditions, such as scoliosis and connective tissue problems. According to the American Heart Association, about 2 percent of the U.S. population has a mitral valve prolapse. Even fewer people experience serious problems associated with the condition.

Mitral valve regurgitation

A variety of heart problems can cause mitral valve regurgitation. You may develop mitral valve regurgitation if you’ve had:

  • endocarditis, or inflammation of the heart’s lining and valves
  • heart attack
  • rheumatic fever

Damage to your heart’s tissue cords or wear and tear to your mitral valve can also lead to regurgitation. Mitral valve prolapse can sometimes cause regurgitation.

Mitral valve disease symptoms vary depending on the exact problem with your valve. It may cause no symptoms at all. When symptoms do occur, they can include:

  • cough
  • shortness of breath, especially when you’re lying down on your back or exercising
  • fatigue
  • lightheadedness

You may also feel pain or tightness in your chest. In some cases, you might feel your heart beating irregularly or quickly.

Symptoms of any type of mitral valve disease usually develop gradually. They might appear or get worse when your body is dealing with extra stress, such as infection or pregnancy.

If your doctor suspects that you may have a mitral valve disease, they will listen to your heart with a stethoscope. Unusual sounds or rhythm patterns can help them diagnose what’s going on.

Your doctor may order additional tests to help confirm a mitral valve disease diagnosis.

Imaging tests

  • Echocardiogram: This test uses ultrasound waves to produce images of the heart’s structure and function.
  • X-ray: This common test produces images on computer or film by sending X-ray particles through the body.
  • Transesophageal echocardiogram: This test produces a more detailed image of your heart than a traditional echocardiogram. During the procedure, your doctor threads a device emitting ultrasound waves into your esophagus, which is located right behind the heart.
  • Cardiac catheterization: This procedure allows your doctor to do a variety of tests, including getting an image of the heart’s blood vessels. During the procedure, your doctor inserts a long, thin tube into your arm, upper thigh, or neck and threads it up to your heart.
  • Electrocardiogram (ECG or EKG): This test records your heart’s electrical activity.
  • Holter monitoring: This is a portable monitoring device that records your heart’s electrical activity over a period of time, usually 24 to 48 hours.

Tests to monitor heart activity

Stress tests

Your doctor may want to monitor you while you exercise to determine how your heart responds to physical stress.

Treatment for mitral valve disease may not be necessary, depending on the severity of your condition and symptoms. If your case is severe enough, there are three possible treatments or combination of treatments that may correct your condition.

Drugs and medication

If treatment is necessary, your doctor may begin by treating you with medications. There are no medications that can actually fix the structural issues with your mitral valve. Some medications can ease your symptoms or prevent them from getting worse. These medications may include:


In some cases, your doctor may need to perform medical procedures. For example, in cases of mitral valve stenosis, your doctor may be able to use a balloon to open up the valve in a procedure called balloon valvuloplasty.


In severe cases, surgery might be necessary. Your doctor might be able to surgically repair your existing mitral valve to make it function properly. If that isn’t possible, you may need to have your mitral valve replaced with a new one. The replacement might be either biological or mechanical. The biological replacement might be obtained from a cow, pig, or human cadaver.

When the mitral valve does not function as it should, your blood does not flow properly out of the heart. You may experience symptoms such as fatigue or shortness of breath, or you may not experience symptoms at all. Your doctor will use a variety of tests to diagnose your condition. Treatment may involve a variety of medications, medical procedures, or surgery.