Highlights for mirabegron
- Mirabegron oral tablet is only available as a brand-name drug. It doesn’t have a generic version. Brand name: Myrbetriq.
- Mirabegron comes as an extended-release tablet that you take by mouth.
- Mirabegron is used to treat the symptoms of overactive bladder (OAB).
- High blood pressure warning: This drug may cause your blood pressure to increase. If you already have high blood pressure, this drug can make it worse. Your doctor should check your blood pressure regularly while you’re taking this drug.
- Urinary retention warning: This drug may make it harder to empty your bladder if you have bladder obstruction or if you’re taking other medications to treat overactive bladder. Tell your doctor right away if you’re unable to empty your bladder.
- Swelling (edema) warning: In rare cases, this drug may cause swelling of the face, lips, tongue, or throat. If swelling occurs and makes it hard for you to breathe, call 911 or go to the emergency room right away.
What is mirabegron?
Mirabegron is a prescription drug. It comes in the form of an extended-release tablet you take by mouth.
This drug is only available as the brand-name drug Mybetriq. It’s not available as a generic drug.
Why it's used
Mirabegron is used to treat the following symptoms of overactive bladder (OAB) in adults:
- Urge urinary incontinence: a strong need to urinate, with leaking or wetting accidents
- Urgency: a strong need to urinate right away
- Frequency: urinating more often than usual
How it works
This drug belongs to a class of drugs called beta-3 adrenergic agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
This drug works by relaxing the muscle that surrounds your bladder. It may increase your bladder’s ability to store urine. This reduces your symptoms of overactive bladder.
Mirabegron side effects
Mirabegron oral tablet doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects that can occur with mirabegron include:
- high blood pressure
- common cold symptoms, such as nasal congestion, runny nose, or sneezing
- urinary tract infection
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- high blood pressure
- urinary retention (not being able to empty your bladder)
- swelling of your face, lips, tongue, or throat that makes it hard to breathe
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Mirabegron may interact with other medications
Mirabegron oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with mirabegron are listed below.
Taking thioridazine with mirabegron increases the level of thioridazine in your body. This can raise your risk of side effects.
Taking warfarin with mirabegron increases the level of warfarin in your body. This can raise your risk of side effects.
Taking certain heart drugs with mirabegron increases the level of these drugs in your body. This can raise your risk of side effects. Examples of these drugs include:
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
This drug may cause a severe allergic reaction called angioedema. Symptoms can include:
- swelling of your face, lips, tongue, or throat
- trouble breathing
Call 911 or go to the nearest emergency room if you develop these symptoms.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Warnings for people with certain health conditions
For people with liver problems: This drug is processed by your liver. If your liver isn’t working well, more of this drug may stay in your body. This puts you at risk for more side effects.
You shouldn’t take this drug if you have severe liver disease. If you have moderate liver disease, your doctor may adjust your dosage of this drug.
For people with kidney problems: This drug is cleared from your body by your kidneys. If your kidneys aren’t working well, more of this drug may stay in your body. This puts you at risk for more side effects.
If you have end-stage kidney disease, you shouldn’t take this drug. If you have severe kidney disease, your doctor may adjust your dosage of this drug.
For people with high blood pressure: If you have a history of high blood pressure, this drug may make your condition worse. Your doctor should check your blood pressure regularly while you’re taking this drug. If your high blood pressure is severe, you shouldn’t take this drug.
For people with bladder outlet obstruction: This drug may make it harder to empty your bladder if you have bladder obstruction or if you’re taking other medications to treat overactive bladder. Tell your doctor right away if you’re not able to empty your bladder.
Warnings for other groups
For pregnant women: This drug is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the pregnancy.
Call your doctor if you become pregnant while taking this drug.
For women who are breastfeeding: It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For children: The safety and effectiveness of this drug hasn’t been established for children younger than 18 years.
How to take mirabegron
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Drug forms and strengths
- Form: oral extended-release tablet
- Strengths: 25 mg, 50 mg
Dosage for overactive bladder (OAB)
Adult dosage (ages 18 years and older)
The typical starting dosage is 25 mg taken by mouth once per day. If your symptoms don’t improve within 8 weeks of taking this drug, your doctor may increase your dosage to 50 mg taken once per day. The maximum dosage is 50 mg taken once per day.
Child dosage (ages 0–17 years)
This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.
Special dosage considerations
- For people with kidney disease: If you have severe kidney disease, your dosage of mirabegron shouldn’t be more than 25 mg per day.
- For people with liver disease: If you have moderate liver disease, your dosage of mirabegron shouldn’t be more than 25 mg per day.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Take as directed
Mirabegron is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: Your symptoms of overactive bladder won’t get better. You may still have a strong urge to urinate, along with leaking or wetting accidents. You may also urinate more often than usual.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. You may have the following symptoms:
- heart rhythm problems (palpitations)
- increased heart rate
- high blood pressure
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: If you miss a dose of this drug, skip the dose and start taking this drug again the next day. Don’t take two doses of this drug on the same day. This could cause dangerous side effects.
How to tell if the drug is working: Your symptoms caused by overactive bladder should get better.
Important considerations for taking mirabegron
Keep these considerations in mind if your doctor prescribes mirabegron for you.
- Don’t crush, cut, or chew the tablet.
- You should swallow each tablet whole with a glass of water.
- Keep this drug at room temperature at 77°F (25°C). It can be stored briefly at a temperature between 59°F (15°C) and 86°F (30°C).
- Keep the medication bottle closed.
- Don’t store this medication in moist or damp areas, such as bathrooms.
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.
When traveling with your medication:
- Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
- Don’t worry about airport X-ray machines. They can’t hurt your medication.
- You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
- Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
During your treatment with this drug, your doctor will monitor your:
- symptoms of overactive bladder
- blood pressure
Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.
Are there any alternatives?
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.