Mesenteric lymphoma is a cancer that develops in a layer of tissue inside your abdomen. It often causes a noticeable lump and stomach pain. Other symptoms include cramping, loss of appetite, and unintentional weight loss.
Mesenteric lymphoma is a cancer that develops in lymph nodes inside of your mesentery. The mesentery is a folded membrane that’s attached to your intestines and abdominal wall to keep them in place.
The most common type of mesenteric lymphoma is follicular lymphoma. Follicular lymphoma is the second most common type of non-Hodgkin’s lymphoma. It develops in a kind of white blood cells called B cells.
Mesenteric lymphoma is referred to as primary mesenteric lymphoma when it develops in your mesentery. It’s called secondary mesenteric lymphoma if it spreads to your mesentery from other parts of your body.
Read on to learn more about mesenteric lymphoma including what causes it, potential symptoms, and treatment options.
Lymphoma is a group of cancers that develop in your lymph system and are characterized by the uncontrolled replication of white blood cells. It’s broadly divided into two main categories: non-Hodgkin’s and Hodgkin’s lymphoma.
Mesenteric lymphoma is when lymphoma develops in the lymph nodes inside of your mesentery. Mesenteric tumors are very rare. A
The most common type of lymphoma to develop in your mesentery is called follicular lymphoma. Follicular lymphoma accounts for about
A more aggressive type of lymphoma called diffuse large B-cell lymphoma can also develop in your mesentery.
Is mesenteric lymphoma curable?
Little is known about the outlook of mesenteric lymphoma due to its rarity. Cases of mesenteric lymphoma being successfully treated have been reported in the medical literature.
For example, in a 2019 study published in Clinical Lymphoma Myeloma and Leukemia, researchers reported successful treatment of diffuse large B-cell lymphoma affecting the mesentery with chemotherapy and radiation therapy.
Mesenteric lymphoma often causes a noticeable abdominal mass and abdominal pain. Other symptoms can include:
A gluten insensitivity disease called dermatitis herpetiformis — which is an itchy, blistering rash — can increase your chance of developing lymphoma. The most common type of lymphoma associated with dermatitis herpetiformis is enteropathy-associated T-cell lymphoma.
In rare cases, people with mesenteric lymphoma may also develop thrombocytopenia. Thrombocytopenia is when your body produces a fewer than normal level of platelets and your blood doesn’t clot properly. Symptoms include easy bruising or unexpected or prolonged bleeding.
Mesenteric panniculitis is also
In a 2022 case study, researchers presented a case of a woman in her 60s with mesenteric lymphoma. She reportedly experienced nausea, vomiting, and abdominal pain for several days. Examination revealed she had bowel obstruction caused by two mesenteric lymphoma tumors.
Researchers aren’t exactly sure why some people develop mesenteric lymphoma, but the most common type of mesenteric lymphoma is follicular lymphoma.
In most cases, it’s not known why follicular lymphoma develops. It’s more common in white Americans than Asian or African Americans, and about half of people are over the
Exposure to some pesticides and herbicides are
Your doctor will begin a diagnosis by asking you about your symptoms and reviewing your medical history. They may be able to feel a lump in your abdomen during a physical exam.
The next step of the diagnostic process involves imaging scans. Your doctor will likely order computed tomography (CT) scans to help identify enlarged lymph nodes as well as the size and location of your tumor.
A characteristic feature of mesenteric lymphoma on a CT scan is the “sandwich sign” or “hamburger sign” named after the shape of the mass.
To confirm that you have cancer, a
After a surgical biopsy is performed, a pathologist will examine the retrieved specimen under a microscope to determine if it is cancerous or noncancerous. If it is cancerous, a pathologist can often determine the origin of the cancer.
Mesenteric lymphoma is primarily treated with surgery to remove the tumor followed by chemotherapy.
A mixture of chemotherapy drugs is often administered. In a 2019 study published in Clinical Lymphoma Myeloma and Leukemia, 23 people with diffuse large B-cell mesentery lymphoma were treated with R-CHOP or
The R-Chop regimen contains:
And the R-EPOCH regimen contains:
Three of the 23 participants in the study also received a bone marrow transplant.
Due to its rarity, it’s not clear what the outlook is for most people with mesenteric lymphoma. Most of the research that’s available comes from individual case studies or small series.
The 5-year relative survival rate of follicular lymphoma in general is
The 5-year relative survival rate for diffuse large B-cell lymphoma is 73% and 74% for people with cancer contained in one area.
Mesenteric lymphoma develops in the lymph nodes of a layer of tissue in your abdomen called the mesentery.
The most common subtype is follicular lymphoma, but a more aggressive type of lymphoma called diffuse large B-cell lymphoma has also been reported.
More research is needed to fully understand the best way to treat mesenteric lymphoma and its long-term outlook. Some people have successfully been treated with surgery and chemotherapy.