Lyme disease results from the bite of an infected tick. It can cause many symptoms, including a bull’s-eye rash and joint pain, and may result in post-Lyme disease syndrome.

Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi.

B. burgdorferi is transmitted to humans by a bite from an infected black-legged or deer tick. The tick becomes infected after feeding on infected deer, birds, or mice.

A tick has to be present on the skin for approximately 36 to 48 hours to transmit the infection. Many people with Lyme disease have no memory of a tick bite.

Lyme disease was first recognized in the town of Old Lyme, Connecticut, in 1975. It’s the most common tick-borne illness in Europe and the United States.

People who live or spend time in wooded areas known for transmission of the disease are more likely to get this illness. Additionally, people with domesticated animals that visit wooded areas also have a higher risk of getting Lyme disease.

People with Lyme disease may react to it differently. Symptoms can vary in severity.

Although Lyme disease is commonly divided into three stages — early localized, early disseminated, and late disseminated — symptoms can overlap. Some people will also present in a later stage of disease without having symptoms of earlier disease.

These are some of the more common symptoms of Lyme disease:

Get medical attention immediately if you have any of these symptoms.

Lyme disease symptoms in children

Children generally experience the same Lyme disease symptoms as adults.

They usually experience:

  • fatigue
  • joint and muscle pain
  • fever
  • other flu-like symptoms

These symptoms may occur soon after the infection, or months or years later.

You may also notice some psychological symptoms in your child. According to a 2019 review, some parents reported the following psychological issues in their child with Lyme disease:

  • anger or aggression
  • mood changes
  • depression
  • nightmares

If your child seems to be acting differently and can’t explain why or what they’re feeling, it’s important to talk with their doctor, as these changes could be a sign of many conditions, including Lyme disease.

Post-Lyme disease syndrome

If you’re treated for Lyme disease with antibiotics but continue to experience symptoms, it is referred to as post-Lyme disease syndrome or post-treatment Lyme disease syndrome.

About 10 to 20 percent of people with Lyme disease experience this syndrome, according to a 2016 article published in the New England Journal of Medicine. The cause is still unknown.

Post-Lyme disease syndrome can affect mobility and cognitive skills. Treatment is primarily focused on easing pain and discomfort. Most people recover, but it can take months or years.

Post-Lyme disease syndrome symptoms

The symptoms of post-Lyme disease syndrome are similar to those that occur in the earlier stages of the condition.

These symptoms may include:

Lyme disease is caused by the bacterium Borrelia burgdorferi (and rarely, Borrelia mayonii).

B. burgdorferi is transmitted to people through the bite of an infected black-legged tick, also known as a deer tick.

According to the Centers for Disease Control and Prevention (CDC), infected black-legged ticks transmit Lyme disease in the Northeastern, Mid-Atlantic, and North Central United States. Western black-legged ticks transmit the disease on the Pacific Coast of the United States.

Diagnosing Lyme disease begins with a review of your health history, which includes looking for reports of tick bites or residence in an endemic area.

A doctor or other healthcare professional will also perform a physical exam to look for the presence of a rash or other symptoms characteristic of Lyme disease.

Testing during early localized infection is not recommended.

Blood tests are most reliable a few weeks after the initial infection, when antibodies are present. A healthcare professional may order the following tests:

  • Enzyme-linked immunosorbent assay (ELISA) is used to detect antibodies against B. burgdorferi.
  • Western blot is used to confirm a positive ELISA test. It checks for the presence of antibodies to specific B. burgdorferi proteins.
  • Polymerase chain reaction (PCR) is used to evaluate people with persistent Lyme arthritis or nervous system symptoms. It’s performed on joint fluid or cerebrospinal fluid (CSF). PCR testing on CSF for diagnosis of Lyme disease is not routinely recommended due to low sensitivity. A negative test doesn’t rule out the diagnosis. In contrast, most people will have positive PCR results in joint fluid if tested before antibiotic therapy.

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Lyme disease is best treated in the early stages. Treatment for early localized disease is a simple 10- to 14-day course of oral antibiotics to eliminate the infection.

Medications used to treat Lyme disease include:

  • doxycycline, amoxicillin, or cefuroxime, which are first-line treatments in adults and children
  • cefuroxime and amoxicillin, which are used to treat people who are breastfeeding

Intravenous (IV) antibiotics are used for some forms of Lyme disease, including those with cardiac or central nervous system (CNS) involvement.

After improvement and to finish the course of treatment, healthcare professionals will typically switch to an oral regimen. The complete course of treatment usually takes 14 to 28 days.

Lyme arthritis, a late-stage symptom of Lyme disease that may present in some people, is treated with oral antibiotics for 28 days.

There is no evidence that Lyme disease is contagious between people. Also, according to the CDC, there are no reports of Lyme disease being transmitted through breast milk.

Lyme disease is an infection caused by bacteria transmitted by black-legged deer ticks. These bacteria are found in bodily fluids, but there’s no evidence that Lyme disease can be transmitted to another person through sneezing, coughing, or kissing.

There is also no evidence that Lyme disease can be sexually transmitted or transmitted through a blood transfusion.

Lyme disease can occur in three stages:

  • early localized
  • early disseminated
  • late disseminated

The symptoms you experience will depend on which stage the disease is in.

The progression of Lyme disease can vary by person. Some people who have it don’t go through all three stages.

Stage 1: Early localized disease

Symptoms of Lyme disease usually start 3 to 30 days after the tick bite. One of the earliest signs of the disease is a bull’s-eye rash.

The rash occurs at the site of the tick bite, usually, but not always, as a central red spot surrounded by a clear spot with an area of redness at the edge. It may be warm to the touch, but it’s not painful and doesn’t itch. This rash will gradually fade in most people.

The formal name for this rash is erythema migrans.

Some people with lighter skin have a rash that’s solid red. Some people with darker skin may have a rash that resembles a bruise.

The rash can occur with or without systemic viral or flu-like symptoms.

Other symptoms commonly seen in this stage of Lyme disease include:

Stage 2: Early disseminated Lyme disease

Early disseminated Lyme disease can occur months after the tick bite.

You’ll have a general feeling of being unwell. A rash may appear in areas other than the tick bite.

This stage of the disease is primarily characterized by evidence of systemic infection, which means infection has spread throughout the body, including to other organs.

Symptoms can include:

The symptoms of stages 1 and 2 can overlap.

Stage 3: Late disseminated Lyme disease

Late disseminated Lyme disease occurs when the infection hasn’t been treated in stages 1 and 2. Stage 3 can occur months or years after the tick bite.

This stage is characterized by:

  • arthritis of one or more large joints
  • brain disorders, such as encephalopathy, which can cause short-term memory loss, difficulty concentrating, mental fogginess, problems with following conversations, and sleep disturbance
  • numbness in the arms, legs, hands, or feet

According to the CDC, as of 2019, the U.S. states with the highest incidence of Lyme disease include:

  • Pennsylvania
  • New York
  • New Jersey
  • Maine
  • Wisconsin
  • New Hampshire
  • Minnesota
  • Maryland
  • Connecticut
  • Virginia

People who work outdoors are at an elevated risk of Lyme disease, including those who work in:

  • construction
  • landscaping
  • forestry
  • farming
  • park or wildlife management

The majority of tick bites happen in the summer when ticks are the most active and people spend more time outside. However, it’s also possible to get Lyme disease from tick bites in early fall, and even in late winter if the weather is unseasonably warm.

Lyme disease prevention mostly involves decreasing your risk of experiencing a tick bite.

Take the following steps to prevent tick bites:

  • Wear long pants and long-sleeve shirts when outdoors.
  • Make your yard unfriendly to ticks by clearing wooded areas, keeping underbrush to a minimum, and putting woodpiles in areas with lots of sun.
  • Use insect repellent. One with 10 percent DEET will protect you for about 2 hours. Don’t use more DEET than what’s required for the time you’ll be outside. Don’t use it on the hands of young children or the faces of children under the age of 2 months old.
  • Oil of lemon eucalyptus has been shown to give the same protection as low concentrations of DEET against mosquitoes, and may be helpful against ticks if you don’t have traditional insect repellent. It also shouldn’t be used on children under 3 years old.
  • Be vigilant. Check your children, pets, and yourself for ticks. If you’ve had Lyme disease, don’t assume you can’t get it again. You can get Lyme disease more than once.
  • Remove ticks with tweezers. Apply the tweezers near the head or the mouth of the tick, and pull gently. Check to be certain that all tick parts have been removed.

Contact a doctor if and whenever a tick bites you or your loved ones.

Ticks that are infected with the bacterium B. burgdorferi can attach to any part of your body. They’re more commonly found in areas of your body that are hard to see, such as the scalp, armpits, and groin area.

The infected tick must be attached to your body for at least 36 hours to transmit the bacterium.

Most people with Lyme disease have been bitten by immature ticks, called nymphs. These tiny ticks are very difficult to see. They feed during the spring and summer. Adult ticks also carry the bacteria, but they’re easier to see and can be removed before transmitting it.

There’s no evidence that Lyme disease can be transmitted through air, food, or water. There’s also no evidence that it can be transmitted between people through touching, kissing, or having sex.

After you’ve been treated for Lyme disease with antibiotics, it may take weeks or months for all the symptoms to disappear.

You can take these steps to help promote your recovery:

Some commercial laboratories will test ticks for Lyme disease.

Although you may want to have a tick tested after it bites you, the CDC doesn’t recommend testing for the following reasons:

  • Commercial laboratories that offer tick testing aren’t required to have the same stringent quality control standards as those for clinical diagnostic laboratories.
  • If the tick tests positive for a disease-causing organism, it doesn’t necessarily mean you have Lyme disease.
  • A negative result could lead you to the false assumption that you don’t have an infection. You could have been bitten by a different tick that transmitted Lyme disease.
  • If you have Lyme disease, you’ll probably start showing the symptoms before you get the tick test results, and you shouldn’t wait to start treatment.

Once you’ve come in from outside, one of the best ways to check yourself for ticks is to take a shower and bath.

Other than that, do your best to check your clothes, especially the folds of your clothes, knowing that ticks can be very small and hard to spot. Running your hands through your hair is also a good idea.

How to remove ticks

According to the CDC, the best way to remove a tick is to:

  1. Use a pair of tweezers to grab the tick.
  2. Steadily pull upward, being careful not to twist the tweezers (this may cause the mouth parts of the tick to break off and stay stuck in the skin).
  3. After removing the tick, clean the bite area with soap and water, or rubbing alcohol.
  4. Don’t crush the tick. Dispose of it by putting it in alcohol, flushing it down the toilet, or putting it in a sealed bag and in the trash.