Sepsis can trigger inflammation throughout your body and can put you at high risk of kidney failure. On the other hand, having kidney failure can weaken your immune system and increase your risk of sepsis.
Sepsis is a life threatening condition caused by an intense response of your immune system to an infection.
Sepsis triggers inflammation throughout your body that can result in multiple organ failure. In fact, sepsis is the most common risk factor of acute kidney failure and is present in
Having kidney failure may also raise your risk of developing sepsis. People with kidney failure often have weakened immune systems that can put them at an increased risk of infections.
Read on to learn about the connection between sepsis and kidney disease.
Sepsis can cause acute kidney failure
Sepsis is the
- dysfunction of small blood vessels
- metabolic reprogramming where your body prioritizes sugars over fat as its main energy source, which can lead to an “
People with sepsis tend to have
Kidney disease puts you at risk of sepsis
Having kidney disease can put you at risk of developing sepsis by weakening your immune system and increasing your chances of developing a blood infection.
Kidney disease and your immune system
Dialysis and blood infections
People on dialysis have a vascular access site where a catheter (thin tube) or graft is inserted into a blood vessel. Having a vascular access site can introduce bacteria into your bloodstream and put you at risk of developing sepsis. More than
Your risk of infection depends on which type of vascular access site you have.
In a large 2020 study of more than 870 000 people, researchers found that about 30% of people on hemodialysis in the United States from 2006 to 2014 developed sepsis at an average follow-up of 1.64 years. People with catheters and grafts had a significantly higher risk than people with fistulas. Hemodialysis is the most common type of dialysis.
Sepsis and acute kidney failure are both medical emergencies. It’s important to get immediate emergency medical attention. Call 911 or local emergency services if you or somebody you’re with has symptoms of either condition.
Symptoms of sepsis in adults can include:
- confusion, slurred speech, incoherence
- difficulty breathing or breathing very fast
- a rash that doesn’t fade if you roll a glass over it
- blue, gray, or blotchy skin, tongue, or lips (people with dark skin may be able to better see discoloration on their palms or soles of their feet)
- fever, shivering, or feeling cold
- clammy or sweaty skin
- extreme pain
In babies or young children, you may also notice that they:
- are sleepier than normal
- don’t respond or feed normally
- have a weak and abnormally high-pitched cry
Symptoms of acute kidney failure
Symptoms of acute kidney failure usually appear within hours to days and can include:
Treatment for sepsis and acute kidney failure requires urgent care in a hospital where doctors or healthcare professionals can closely monitor you to prevent life threatening complications. Treatment largely involves treating the underlying infection and managing your symptoms.
Treatment may include:
- Antibiotics: Antibiotics help your body fight off bacterial infections. Every hour that antibiotics are delayed is associated with an 8% increased risk of death in people with sepsis and acute kidney failure.
- Antivirals: Antibiotics aren’t effective for viral infections, so you may be given antiviral drugs instead. Antibiotics are usually administered when the cause isn’t known.
- Fluids: Fluids administered through an intravenous (IV) line can help prevent dehydration or kidney failure.
- Oxygen: You may be given oxygen through a mask or tube to raise the levels of oxygen circulating in your blood.
- Blood pressure medications: You may receive vasopressors to raise your blood pressure if your blood pressure drops dangerously low.
- Other medications: Your medical team may also administer medications to:
- balance your blood sugar
- prevent blood clots
- prevent other complications
- control your levels of potassium and calcium
- Dialysis: If sepsis has caused acute kidney failure, you may need dialysis to reduce levels of toxic chemicals elevated too high in your blood that are normally filtered by your kidneys.
Sepsis with acute kidney failure is potentially life threatening. If not treated right away, it can lead to multiple organ failure and death.
In a 2022 study, researchers found that the mortality rate among 1,122 people with sepsis was 16.59% but that the mortality rate rose to 25.68% in people who also had kidney failure.
People on dialysis have a
Yes, you can survive sepsis with kidney failure, but quick medical attention is essential.
In a 2018
Some people can make a full recovery from sepsis. The amount of time it takes to recover depends on factors such as:
- the severity of your sepsis
- your overall health
- how long you’re in the hospital
- whether you receive treatment in an intensive care unit (ICU)
Acute kidney failure can lead to lifelong complications including
In a 2022 study, researchers found that people discharged from the hospital with sepsis were at a significantly higher risk of subsequent kidney problems.
Sepsis is a life threatening condition caused by your immune system’s reaction to an infection. Acute kidney failure is a common complication of sepsis. Both conditions require immediate emergency medical attention.
People with kidney disease are also at an elevated risk of developing sepsis due to frequently having weakened immune systems and having a high risk of blood infection associated with dialysis.