Indapamide, Oral Tablet

Medically reviewed by University of Illinois-Chicago, Drug Information Group on November 14, 2016Written by University of Illinois-Chicago, Drug Information Group on November 23, 2017

Highlights for indapamide

  1. Indapamide oral tablet is available as a generic drug. It doesn’t have a brand-name version.
  2. Indapamide comes only as a tablet you take by mouth.
  3. Indapamide is used to treat high blood pressure. It’s also used to treat salt and fluid retention (edema) in people with congestive heart failure.

Important warnings

  • Anuria warning: If you have anuria (your body doesn’t make urine), you shouldn’t take this drug.
  • Sulfa drugs warning: Don’t use indapamide if you’re allergic to sulfonamide-derived (sulfa) drugs.
  • Low blood potassium/salt warning: Indapamide can cause low blood potassium or low sodium levels. Call your doctor if you have these symptoms while taking this drug:
    • intense thirst
    • tiredness
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • nausea
    • vomiting
    • fast heart rate or pulse

What is indapamide?

Indapamide is a prescription drug. It comes as an oral tablet.

Indapamide is only available as a generic drug. Generic drugs usually cost less than brand-name versions.

Indapamide may be taken in combination with other drugs to treat high blood pressure or swelling.

Why it's used

Indapamide is used to lower blood pressure in people with high blood pressure. It will help control your high blood pressure but it won’t cure it. When taken long-term, it may prevent you from having a heart attack or stroke.

Indapamide is also used to treat salt and fluid retention (edema) in people with congestive heart failure. It will help control your swelling or fluid retention, but it won’t cure it. When taken long-term, it may keep your heart failure from getting worse.

How it works

Indapamide belongs to a class of drugs called diuretics (water pills). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Indapamide makes your body get rid of extra water and salt through your urine. This results in less swelling and lowered blood pressure.

Indapamide side effects

Indapamide oral tablet may cause drowsiness. It may also cause other symptoms.

More common side effects

The more common side effects that can occur with indapamide include:

  • headache
  • dizziness
  • fatigue, weakness, or loss of energy
  • muscle cramps or spasms
  • increased urination (during the first few weeks of treatment)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • fast, unexplained weight loss
  • severe skin rash with itching
  • trouble breathing or swallowing

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Indapamide may interact with other medications

Indapamide oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with indapamide are listed below.

Drugs used to treat high blood pressure

When indapamide is taken with other drugs that lower your blood pressure, the blood pressure-lowering effects can be increased. This means that it might lower your blood pressure too much.

Examples of these drugs include:

  • hydrochlorothiazide
  • furosemide
  • propranolol
  • metoprolol
  • lisinopril
  • ramipril
  • losartan
  • valsartan

Lithium

Taking lithium with indapamide can cause lithium to build up in your body. This raises your risk of dangerous effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Indapamide warnings

This drug comes with several warnings.

Allergy warning

Indapamide can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

Using alcohol while taking this drug can cause a sedative effect. You may have slowed reflexes, poor judgment, and sleepiness. This can be dangerous.

Warnings for people with certain health conditions

For people with gout: This drug can cause gouty episodes. Let your doctor know if you have gout.

For people with kidney disease: Indapamide can cause kidney problems. This drug should be used with caution if you have kidney disease.

For people with liver disease: Indapamide can cause fluid and electrolyte imbalances. These imbalances can worsen your liver disease. People with liver disease should use this drug with caution.

For people with lupus: This drug may make your lupus worse. Let your doctor know if you have lupus.

Warnings for other groups

For pregnant women: Indapamide is a category B pregnancy drug. That means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Indapamide should be used during pregnancy only if the potential benefit justifies the potential risk.

For women who are breastfeeding: It isn’t known if indapamide passes into breast milk. If it does, it may cause serious effects in a breastfeeding child. You and your doctor may need to decide if you’ll take this drug or breastfeed.

For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

For children: This drug hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

How to take indapamide

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Drug form and strengths

Generic: Indapamide

  • Form: oral tablet
  • Strengths: 1.25 mg and 2.5 mg

Dosage for high blood pressure (hypertension)

Adult dosage (ages 18–64 years)

  • Typical starting dosage: 1.25 mg taken once per day in the morning.
  • Dosage increases: After 4 weeks, your doctor may increase your dosage to 2.5 mg taken once per day. After another 4 weeks, your doctor may increase your dosage to 5 mg taken once per day. If your blood pressure is still high, your doctor may give you another drug to take along with indapamide.

Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A typical adult dosage may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dosage or a different schedule.

Dosage for fluid retention (edema) in people with congestive heart failure

Adult dosage (ages 18–64 years)

  • Typical starting dosage: 2.5 mg taken once per day taken in the morning.
  • Dosage increases: After one week, your doctor may increase your dosage to 5 mg taken once per day.

Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A typical adult dosage may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dosage or a different schedule.

Dosage warnings

Dosages greater than 5 mg per day haven’t been shown to treat high blood pressure or fluid retention from heart failure better than lower dosages. Dosages this high may cause more side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Take as directed

Indapamide oral tablet is used for long-term treatment of high blood pressure. It’s used for short-term or long-term drug treatment of fluid retention.

This drug comes with serious risks if you don't take it as prescribed.

If you stop taking it suddenly: Don’t stop taking indapamide without talking to your doctor. Stopping this drug suddenly may cause your blood pressure to spike. This may increase your risk of a heart attack or stroke. If you have heart failure, you may experience fluid buildup.

If you don't take it on schedule: Your blood pressure may not improve or may get worse. You may have a higher chance of a heart attack or stroke. If you have heart failure, you may have fluid buildup.

If you don't take it at all: For treatment of high blood pressure: Indapamide reduces high blood pressure. If you don’t take it, your blood pressure will stay high. This raises your risk of having a stroke or heart attack.

For treatment of fluid retention: Your heart will have to work harder and you may have trouble breathing due to fluid buildup.

If you take too much: You may have the following symptoms:

  • nausea
  • vomiting
  • weakness
  • stomach problems
  • changes in the amount of electrolytes in your blood. This can be dangerous.

If you think that you’ve taken too much indapamide, call your doctor right away.

What to do if you miss a dose: If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause dangerous side effects.

How to tell if the drug is working: For treatment of high blood pressure: You won’t be able to feel indapamide working. If you check your blood pressure, your readings should be lower.

For treatment of fluid retention: You should have less swelling or fluid retention.

Important considerations for taking indapamide

Keep these considerations in mind if your doctor prescribes indapamide for you.

General

  • Indapamide can be taken with or without food.
  • Take indapamide at the same time each morning.
  • You can cut or crush the tablet.

Storage

  • Store at room temperature between 68° and 77°F (20°C and 25°C).
  • Don’t freeze this drug.
  • Keep this drug away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t harm your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor may ask you to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this log with you to your doctor appointments.

You may need to buy a blood pressure monitor to check your blood pressure at home.

Clinical monitoring

While being treated with indapamide, your doctor will monitor your:

  • blood pressure
  • electrolyte levels
  • kidney function
  • liver function

Your diet

Your doctor may have you follow a specific diet, such as a low-salt or a high-potassium diet. Foods high in potassium include prunes, bananas, and orange juice.

Sun sensitivity

Indapamide may make your skin sensitive to sunlight. You should wear protective clothing and sunscreen when you’re in the sun.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Hidden costs

You may need to purchase a home blood pressure monitor to keep track of your blood pressure. These are available at most pharmacies.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained here in is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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