We’ve carefully selected these HIV nonprofits because they’re actively working to educate, inspire, and support people living with HIV and their loved ones. Nominate a notable nonprofit by emailing us at nominations@healthline.com.

There isn’t an effective cure for HIV. But there are effective HIV treatments that allow for people with the virus to live a healthy lifestyle. PrEP (pre-exposure prophylaxis) reduces the risk of contracting the virus, and ART (antiretroviral therapy) helps keep the virus under control.

However, the Centers for Disease Control and Prevention (CDC) still estimates that nearly 1 in 8 people may not know they have HIV. This makes awareness, education, and advancing treatments all the more urgent.

Left untreated, HIV will further weaken the immune system and become acquired immunodeficiency syndrome, or AIDS. Though we’ve made great progress in the fight against HIV and AIDS, there’s still much more to be done.

Here are some of the best nonprofit organizations leading the global effort against HIV and AIDS. Whether you’re looking for information, ways to help locally, or want to donate to a worthy cause, they’ve got you covered.

AVAC (formerly the AIDS Vaccine Advocacy Coalition) has worked to end AIDS through HIV prevention since 1995. The organization focuses on policy innovation, improving research (and making it accessible to everyone), and community response networks to provide better answers and resources to people affected by AIDS. Check out their 2016 report on big data for more on their approach to ending AIDS.

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Tweet them @HIVpxresearch

San Francisco AIDS Foundation is celebrating 35 years this year. They’re a powerhouse in tackling HIV at a community level: Nearly 84 percent of expenses support program services, and 50 percent of that goes directly to community-based services. In 2016, the organization provided nearly 17,000 clinical visits, enrolled 54 percent more people on PrEP than in 2015, and gave an estimated 18,000 people access to sterile syringes through its programming and direct services.

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The mission of the International AIDS Society (IAS) is to “lead collective action on every front of the global HIV response.” This member-based organization is one of the largest associations of HIV professionals. More than 180 countries have members. IAS manages two serious scientific conferences, the International AIDS Conference and IAS Conference on HIV Science. These conferences bring together more than 15,000 attendees annually.

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Elizabeth Glaser contracted HIV during a blood transfusion while giving birth to her daughter Ariel. After Ariel passed in 1988, Elizabeth founded the Pediatric AIDS Foundation with two friends. The organization’s goal is to raise money for pediatric HIV and AIDS research and encourage companies to test drugs for HIV-positive children. The organization was renamed in Elizabeth’s honor following her death from AIDS in 1994. They continue Elizabeth’s mission of ending pediatric HIV and AIDs. Much of the organization’s expenses (about 88.5 percent) support programming in 19 countries. This programming provides prevention, testing, or medication for more than 24 million women.

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The Los Angeles-based AIDS Healthcare Foundation was founded in 1987. They’ve provided medical care and advocacy to more than 794,000 people in 39 countries to date. In 2016 alone, the foundation provided 176,950 free HIV tests in the United States and distributed more than 40 million free condoms. Their website also provides an easy search tool for users to find HIV and AIDS services in their area.

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Since 1987, NMAC’s mission has been to “lead with race.” They’re formerly known as the National Minority AIDS Council. NMAC draws attention to racial disparities in communities affected by HIV and AIDS. According to the organization, black women are 20 times more likely than white women to contract HIV. Fifty percent of black gay men (compared to 8 percent of white gay men) will have HIV by the time they’re 35. NMAC hopes that by normalizing and engaging discussions on race — and keeping people of color with HIV in care — we can change the way we think about ending AIDS. In 2015, nearly 74 percent[D1] of expenses went to support programming.

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The Kaiser Family Foundation launched Greater Than AIDS in 2009. They work to provide targeted media and community outreach designed to increase understanding and reduce stigma around HIV and AIDS. The public information-oriented program helms a number of campaigns. These include We Are Family, which emphasizes the role of support systems and family in managing HIV, and We Are Empowered!, directed at engaging women.

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For more than 20 years, AIDS United has used strategic grantmaking, capacity building, and policy advocacy as tools against AIDS. To date, the organization has given $104 million to local communities. They’ve leveraged more than $117 million for other programs that target issues like syringe access, access to care, and prevention. In 2015, AIDS United’s programs helped more than 37,000 people with HIV, from learning about their status, prevention education, and getting direct care. With 93 percent of expenses going directly to programs, it’s no wonder AIDS United earned a four-star rating from Charity Navigator.

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Tweet them @AIDS_United