Several medications help treat and prevent coronary artery disease (CAD). This includes statins to lower cholesterol levels, ACE inhibitors to lower blood pressure, and other drugs that prevent heart attacks.

Coronary artery disease (CAD) occurs when the blood vessels can’t carry enough blood and oxygen to the heart. Typically, this is because the vessels are blocked by a fatty substance called plaque.

The goal of CAD treatment is to control symptoms and stop or slow the progression of the disease. Your doctor may prescribe several medications to help achieve these goals and reduce your risk of heart attack.

Read on to learn how medications help treat CAD and prevent related problems.

A common symptom of CAD is angina or chest pain. If you have angina, your doctor may prescribe short- or long-acting drugs called nitrates to reduce this pain. Nitroglycerin, a type of nitrate, dilates blood vessels and allows the heart to pump blood with less effort. These actions help relieve chest pain.

Beta-blockers are also often prescribed to treat angina. Beta-blockers can slow your heart rate and lower your blood pressure. These actions decrease the amount of oxygen your heart needs to work, which can help relieve angina.

Plaque buildup in your blood vessels is a common feature of CAD. This buildup can cause blood clots to form. These clots can block your vessels and cause a heart attack.

Blood clots are formed by a buildup of platelets, also called thrombocytes, that circulate in blood. These clotting cells bind together into a clot to help your body stop bleeding after an injury. Certain drugs suppress the activity of platelets, making it harder for blood clots to form within your arteries. This effect reduces your risk of heart attack.

Examples of medications that help keep platelets from forming clots include:

  • aspirin
  • clopidogrel (Plavix)
  • eptifibatide (Integrilin)
  • ticagrelor (Brilinta)
  • prasugrel (Effient)

High levels of cholesterol in your blood play a key role in causing atherosclerosis. If you have high cholesterol and can’t lower it through a healthy diet and increased physical activity, your doctor may prescribe daily medications.

Examples of drugs that can help reduce your cholesterol levels include:

Bile acid sequestrants

These drugs help the body get rid of low-density lipoprotein (LDL), or “bad” cholesterol. They’re also known as bile acid-binding resins. Examples include:

  • cholestyramine (Questran)
  • colesevelam hydrochloride (Welchol)
  • colestipol hydrochloride (Colestid)


Fibrates lower triglycerides and raise high-density lipoprotein (HDL), or “good” cholesterol. Examples include fenofibrate (Tricor) and gemfibrozil (Lopid).


Statins work by decreasing overall cholesterol production. Examples include:


Niacin increases HDL and decreases LDL. It’s also known as vitamin B-3. Brand names include Niaspan and Niacor.

Several types of drugs can help lower your blood pressure. These drugs can also help your heart function better in other ways. They include:


High blood pressure can contribute to CAD because it can damage your blood vessels. Beta-blockers help by slowing your heart rate and lowering your blood pressure. These actions also reduce your risk of heart attack, a complication of CAD.

Examples of beta-blockers include:

Calcium channel blockers

Calcium channel blockers help increase the amount of oxygen sent to the heart. They relax the vessels of the heart, allowing oxygen-rich blood to flow to it more easily. Calcium channel blockers also lower blood pressure and relax other blood vessels in the body. These effects can decrease the amount of oxygen the heart needs.

Examples of calcium channel blockers include:

ACE inhibitors and ARBs

Angiotensin II is a hormone in your body that tightens your blood vessels. Tightening blood vessels raise your blood pressure and increase the amount of oxygen your heart needs.

Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) reduce the effects of angiotensin II. They work to prevent increases in blood pressure. These types of medications can lower your risk of stroke or heart attack.

Examples of ACE inhibitors include:

On April 22, 2022, Pfizer issued a voluntary recall of 5 lots of the drug Accupril due to the presence of nitrosamine. Nitrosamine, a known carcinogen with the potential to cause cancer, was found to exist in the drug at levels greater than the Acceptable Daily Intake (ADI) as determined by the FDA. This recall is specific only to a handful of lot numbers and does not affect all Accupril tablets made by Pfizer. If you take Accupril tablets, talk with your pharmacist or doctor and they will help you determine if your medication has been impacted by the recall.

Examples of ARBs include:

Angiotensin–Neprilysin Inhibitors (ARNis)

There was a landmark trial in 2014 that demonstrated the superiority of ARNis in treating heart failure.

These medications reduced cardiovascular death and hospitalization by 20% compared to enalapril. Treatment guidelines prefer it for the treatment of heart failure. ARNis include sacubitril and valsartan (Entresto).

Medications used to treat CAD can:

  • lower your cholesterol levels
  • lower your blood pressure
  • reduce your heart’s workload
  • prevent blood clots
  • increase the amount of oxygen sent to your heart

All of these actions can help reduce your CAD symptoms and prevent serious complications, such as heart attack or stroke.

Your doctor can tell you more about drugs that can help your CAD. Questions you might ask them include:

  • What drugs are best suited for my symptoms and medical history?
  • Am I taking any other medications that might interact with a CAD drug?
  • Are there nondrug ways I can reduce my CAD symptoms?

What are the main drug treatments for heart failure?

The main types of medications used to treat heart failure are:

  • beta-blockers – carvedilol, bisoprolol, and metoprolol succinate
  • angiotensin receptor-neprilysin inhibitors (ARNIs) – sacubitril and valsartan
  • mineral corticoid receptor antagonists (MRAs) – spironolactone and eplenerone
  • sodium-glucose co-transporter 2 Inhibitors (SGLT2i) – empagliflozin
  • loop diuretics – furosemide and bumetanide

Treatment guidelines for heart failure also recommend that African-American patients with heart failure also receive hydralazine/isosorbide dinitrate (Bidil) as it has been shown to improve symptoms/reduce mortality.

What is the best medication for heart failure?

The “best” medication for heart failure will depend on many factors, such as the type of heart failure, age of the individual, and other conditions they may have. Types of medications to treat heart failure include:

  • beta-blockers
  • angiotensin receptor-neprilysin inhibitors (ARNIs)
  • mineral corticoid receptor antagonists (MRAs)
  • sodium-glucose co-transporter 2 Inhibitors (SGLT2i)

What is the new drug for heart failure?

In 2020, the FDA approved a new drug for one type of heart failure, Farxiga (dapagliflozin) oral tablets.

Which drug is commonly used in heart failure?

A new drug, vericiguat (Verquvo), was FDA-approved in 2021 for the reduction of risk of cardiovascular death and following a hospitalization for heart failure.