A gastrointestinal (GI) cocktail is a mixture of medications that you can drink to help ease the symptoms of indigestion.

In this article, we take a look at what makes up a GI cocktail, how effective it is, and whether there are any side effects you should know about.

The term “GI cocktail” doesn’t refer to a specific product. Instead, it refers to a combination of the following three medicinal ingredients:

This chart helps to explain what the GI cocktail ingredients are, why they’re used, and the approximate dose of each ingredient:

IngredientFunctionBrand nameActive ingredient(s)Typical dose
liquid antacidneutralizes stomach acidMylanta or Maaloxaluminum hydroxide, magnesium hydroxide, simethicone 30 mL
anestheticnumbs the inside of the throat, esophagus, and stomachXylocaine Viscousviscous lidocaine5 mL
anticholinergiceases cramps in the stomach and intestines Donnatalphenobarbital, hyoscyamine sulfate, atropine sulfate, scopolamine hydrobromide 10 mL

A GI cocktail is typically prescribed for dyspepsia, more commonly known as indigestion.

Indigestion is not an illness. Instead, it’s typically a symptom of an underlying gastrointestinal issue, like:

When indigestion isn’t caused by another condition, it may be caused by medication, diet, and lifestyle factors such as stress or smoking.

In general, indigestion occurs after eating. Some people experience it on a daily basis, while others only experience it from time to time.

Although most people will likely experience indigestion at some point in their lives, the symptoms can vary from one person to the next.

Some common signs of indigestion include:

A GI cocktail may be prescribed to treat these symptoms, typically in a hospital or emergency room setting.

Sometimes, a GI cocktail is used to try and determine whether chest pain is caused by indigestion or a heart problem.

However, there’s limited research to support the effectiveness of this practice. Some case studies suggest that GI cocktails shouldn’t be used to rule out an underlying heart problem.

A GI cocktail may be effective at relieving indigestion. However, research is lacking and existing literature isn’t current.

In an older 1995 study conducted in a hospital emergency department, researchers assessed symptom relief following the administration of a GI cocktail to 40 patients with chest pain and 49 patients with abdominal pain.

The GI cocktail was often reported to relieve symptoms. However, it was frequently administered alongside other medications, making it impossible to conclude which drugs provided symptom relief.

Other research has questioned whether taking a GI cocktail is more effective than simply taking an antacid on its own.

A 2003 trial used a randomized, double-blind design to evaluate the effectiveness of GI cocktails in treating indigestion. In the study, 120 participants received one of the following three treatments:

  1. an antacid
  2. an antacid and an anticholinergic (Donnatal)
  3. an antacid, an anticholinergic (Donnatal), and viscous lidocaine

Participants ranked their indigestion discomfort on a scale both before and 30 minutes after the medication was administered.

The researchers reported no significant differences in pain ratings between the three groups.

This suggests that an antacid alone may be just as effective at relieving pain associated with indigestion, but additional studies are needed to know for sure.

Finally, a 2006 report for physicians concluded that an antacid alone is preferable to treat indigestion.

Drinking a GI cocktail does carry a risk of side effects for each of the ingredients that are used in the mixture.

Possible side effects of antacids (Mylanta or Maalox) include:

  • constipation
  • diarrhea
  • headache
  • nausea or vomiting

Possible side effects of viscous lidocaine (Xylocaine Viscous) include:

  • dizziness
  • drowsiness
  • irritation or swelling
  • nausea

Possible side effects of anticholinergics (Donnatal) include:

  • bloating
  • blurred vision
  • constipation
  • difficulty sleeping
  • dizziness
  • drowsiness or fatigue
  • dry mouth
  • headaches
  • nausea or vomiting
  • reduced sweating or urination
  • sensitivity to light

There are several other medications that can treat indigestion. Many are available without a prescription from a doctor.

A healthcare professional can help you determine which is the best choice for your specific symptoms. Some options include:

  • H2 receptor blockers. These drugs, including Pepcid, are often used to treat conditions that cause excess stomach acid.
  • Prokinetics. Prokinetics such as Reglan and Motilium can help control acid reflux by strengthening a muscle in the lower esophagus. These drugs require a prescription from a doctor.
  • Proton pump inhibitors (PPIs). Proton pump inhibitors such as Prevacid, Prilosec, and Nexium block the production of stomach acid. They’re more powerful than H2 receptor blockers. These types of medications are available over-the-counter (OTC) and by prescription.

Medication isn’t the only way to treat indigestion. Lifestyle changes can also help reduce or prevent symptoms.

Some ways that you may be able to relieve or ease your indigestion include the following self-care treatments:

  • If you smoke, seek help to stop.
  • Eat smaller portions of food at more frequent intervals.
  • Eat at a slower pace.
  • Don’t lie down after you eat.
  • Avoid foods that are deep fried, spicy, or greasy, which are more likely to trigger indigestion.
  • Cut down on coffee, soda, and alcohol.
  • Speak to a pharmacist to see if you’re taking medications that are known to irritate the stomach, such as over-the-counter pain medication.
  • Get enough sleep.
  • Try soothing home remedies such as peppermint or chamomile teas, lemon water, or ginger.
  • Try to reduce the sources of stress in your life and find time to relax through yoga, exercise, meditation, or other stress-reduction activities.

Some indigestion is normal. But you shouldn’t ignore persistent or severe symptoms.

You should seek medical attention right away if you experience chest pain, unexplained weight loss, or excessive vomiting.

A GI cocktail consists of 3 different ingredients — an antacid, viscous lidocaine, and an anticholinergic called Donnatal. It’s used to treat indigestion and associated symptoms in hospital and emergency room settings.

According to current research, it’s not clear whether a GI cocktail is any more effective at relieving symptoms of indigestion than an antacid alone.