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Tadalafil is a generic version of the prescription drug Cialis. Doctors prescribe it to treat erectile dysfunction and benign prostatic hyperplasia. It helps relieve erectile dysfunction by increasing blood flow to the penis.

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Generic Cialis is called tadalafil, which is the active ingredient in Cialis. Cialis is Food and Drug Administration (FDA) approved to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BHP). Generic tadalafil became more widely available after 2018.

According to the FDA, generic medications provide the same benefits as brand-name drugs. Generic medications are considered against the same standards as brand-name versions to make sure that they reach the same level of:

  • strength
  • safety
  • effectiveness
  • stability
  • quality

Usually, generic drugs aren’t available until the expiration of the brand name’s patent. Eli Lilly and Company’s patent for Cialis expired in 2018, opening the market to generic competitors.

Keep reading to learn everything you need to know about generic Cialis.

Tadalafil, or generic Cialis, is most commonly used to treat erectile dysfunction (ED). However, it’s also used to treat benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension.

Along with other medications used to treat ED, Cialis and generic tadalafil are only available by prescription.

Tadalafil, like other phosphodiesterase type 5 (PDE5) inhibitors, can interact dangerously with nitrate-based medications, such as Imdur and Nitrostat. This includes nitrates used to treat heart conditions and high blood pressure.

Generic versions of tadalafil that are FDA-approved are just as effective as Cialis. The FDA provides a rigorous inspection process to make sure companies selling these generic drugs undergo good manufacturing processes and that their drugs provide the same clinical benefits.

FDA-approved tadalafil and Cialis are cleared for treating ED and both drugs are PDE5 inhibitors that work in the same way — by dilating blood vessels in order to increase blood flow to the penis.

While the results are very similar, one of the biggest differences between the two is the price. Generic tadalafil pills are often less than half the price of Cialis.

A 2019 study found that from 2012 to 2017, the median price of Cialis jumped from $127 to $365 for 30 tablets. Generic brands start at around $100 for 30 tablets.

Price depends on the strength of the dose per pill and the pharmacy you’re buying it from. Coupons and discounts may be available. Cialis and tadalafil can both be bought online. More information can be found here.

Finding generic tadalafil

Keep in mind that not all brands of generic tadalafil are FDA approved. You can use the search tool on the FDA website to find an up-to-date list of approved brands.

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Tadalafil falls into a category of drugs called PDE5 inhibitors.

When you become sexually aroused, the nerve terminals and blood vessels in your penis release a molecule called nitric oxide (NO). NO activates a series of chemical reactions that increase blood flow to your penis by relaxing your blood vessels.

Tadalafil and other PDE5 inhibitors like Viagra block an enzyme called PDE5. By inhibiting PDE5, nitric oxide can be more effective at relaxing blood vessels in the penis and increasing blood flow. This ultimately results in a stronger erection.

However, both psychological and physiological factors can disrupt the sequence of reactions needed to achieve an erection. For PDE5 inhibitors to work, you still need to be sexually aroused. If your ED is caused by psychological factors, PDE5 inhibitors won’t help treat ED.

Tadalafil is thought to help treat symptoms of BPH by relaxing the muscles in your prostate and bladder. It helps improve symptoms of pulmonary arterial hypertension by relaxing the blood vessels in your lungs.

Tadalafil is taken orally in the form of tablets. The strength of these tablets generally ranges from 2.5 to 20 milligrams (mg).

Tadalafil tablets can either be taken once per day or as needed.

If you’re taking them once per day, your doctor will typically start you on a dose of about 2.5 mg and adjust based on how well it’s working for you and whether you’re experiencing any side effects. Avoid taking more than one tablet per day.

You should take the tablets at the same time each day, so you have consistent levels of the medication in your system. Since the medication is always in your system, you have the ability to get an erection without planning ahead of time. You can have sex at any time.

When used on an as-needed basis, your doctor will likely start you at about 10 mg per day. You can have sex about 30 minutes after taking the tablet.

A typical dose of tadalafil to treat BPH is 5 mg per day.

You’ll need a prescription to get generic Cialis, also known as tadalafil. There are several options for how you can get generic Cialis, including starting with talking with your doctor. You can meet with them and discuss your symptoms, and they will prescribe tadalafil for you.

Whenever you’re buying medication online, it’s important to make sure the seller is reliable and reputable. Unfortunately, there are a lot of online sellers offering discounted medications, but many of them may not be selling safe or legitimate versions of Cialis or generic Cialis.

When purchasing from a non-reputable seller, it can be very difficult to establish the safety and effectiveness of the medication, the ingredients, and the dose.

Here’s a side-by-side comparison of some of the best places to find generic Cialis online:

NamePrice as of Nov. 2023DosesMeds shipped directly/prescription?Is branded Cialis available too?
Hims$6–$25 per dose2.5–20 mg• shipped to your home
• prescription required
• doctor available through service
yes
Roman$8–$44 per dose2.5–20 mg• shipped to your home
• prescription required
• doctor available through service
yes
Lemonaidstarting around $8 per dose5–20 mg• shipped to your home
• prescription required
• doctor available through service
no
Rex MD$3–$10 per dose2.5-20mg• shipped to your home
• prescription required
• doctor available through service
yes
Optum Storestarts at $7 per dose5–20 mg• shipped to your home
• prescription required
• doctor available through service
yes

Looking for more in-depth reviews of these companies?

We took a closer look at these online services and analyzed their customer reviews, variety of products, pricing, and shipping policies.

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The side effects of generic tadalafil are the same as Cialis. There are many potential side effects, and the following list isn’t comprehensive. If you notice anything else concerning after starting tadalafil, talk with your doctor.

Common side effects of tadalafil

Some of the most common side effects of Cialis and tadalafil are:

Serious side effects of tadalafil

Tadalafil can cause a number of more serious side effects that require medical attention, such as:

Relatively rare side effects of tadalafil include:

It’s important to let your doctor know what other medications you’re taking before you start taking tadalafil. A number of medications can interact with tadalafil and have serious side effects.

According to the FDA, combining Cialis with nitroglycerin can lower blood pressure, which can lead to fainting, dizziness, headaches, or even death.

It’s recommended that you avoid tadalafil if you’re taking any of the following medications:

  • amyl nitrite
  • boceprevir
  • erythrityl tetranitrate
  • isosorbide dinitrate
  • isosorbide mononitrate
  • nitroglycerin
  • pentaerythritol tetranitrate
  • propatyl nitrate
  • riociguat
  • telaprevir

Some categories of medications known to interact with tadalafil include:

  • angina drugs
  • antibiotics
  • epilepsy drugs
  • hepatitis C drugs
  • high blood pressure drugs
  • HIV drugs
  • oral antifungal drugs
  • other ED drugs
  • pulmonary arterial hypertension drugs
  • stomach acid drugs

When taking tadalafil, it’s often recommended that you avoid grapefruit juice and minimize your use of tobacco or alcohol since they can interact with the medication.

Discuss your tobacco and alcohol habits with your doctor before taking any type of PDE5 inhibitor.

Tadalafil is the affordable, generic version of brand-name Cialis.

Cialis was originally created and is produced by the pharmaceutical company Eli Lilly. Generic tadalafil became available in 2018 after the patent protection ended.

Both brand-name Cialis and tadalafil have been shown to be safe and provide the same treatment effects for erectile dysfunction, but tadalafil is available for a fraction of the price of Cialis.

The side effects of generic Cialis are similar to the side effects of Cialis. Common side effects can include:

Rare, but very serious, side effects include low blood pressure, vision problems, and priapism.

If you are experiencing any of these side effects, especially the more serious side effects, it is worth talking with your doctor as soon as possible to discuss your side effects.

Since generic Cialis or tadalafil can be manufactured by other companies besides Eli Lilly — the manufacturer of Cialis — the look of the pill can differ. However, popular companies like Hims and Roman prescribe generic Cialis and their pills look yellow-ish in color and are oval or circle-shaped.

When tadalafil is taken as needed for ED, it can start working within 30 to 45 minutes. It typically reaches peak effect 2 hours after it’s taken. But in some cases, it can still be effective up to 36 hours after it was taken.

Like other ED drugs that are taken as needed for ED, it must be taken in advance of when you plan to be sexually active to give it time to start working.

There are several options to treat ED aside from oral medications like tadalafil, including:

  • sex therapy for emotional, psychological, and relationship issues related to ED

  • suppositories (Alprostadil)

Generic versions of Cialis have been available since 2018 under the name tadalafil. A long list of companies has been FDA approved to produce tadalafil for treating ED and BPH.

Generic versions of Cialis that are FDA-approved are equally as effective and safe as brand-name Cialis. Generic versions are often less than half the cost.