Zepbound (tirzepatide) is a prescription drug that’s used to help with weight loss in certain adults. The drug comes as a liquid solution inside prefilled injection pens. It’s usually injected once weekly.

Zepbound is used with a reduced-calorie diet and increased exercise to help with weight loss and long-term weight management. It’s prescribed to adults with either:

The active ingredient in Zepbound is tirzepatide. An active ingredient is what makes a drug work.

Zepbound belongs to a group of drugs called dual glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists.

This article describes the dosage of Zepbound, as well as its strengths and how to take it. To learn more about Zepbound, see this in-depth article.

The table below highlights the basics of Zepbound’s dosage. All strengths are listed in milligrams per milliliters of solution (mg/mL).

Zepbound’s formZepbound’s strengthsTypical dosageMaximum dosage
liquid solution inside prefilled, single-dose injection pens• 2.5 mg/0.5 mL
• 5 mg/0.5 mL
• 7.5 mg/0.5 mL
• 10 mg/0.5 mL
• 12.5 mg/0.5 mL
• 15 mg/0.5 mL
When starting treatment, 2.5 mg injected once per week for 4 weeks. After that, 5 mg injected once per week.15 mg injected once per week

Keep reading for more details about Zepbound’s dosage.

What is Zepbound’s form?

Zepbound comes as a liquid solution inside prefilled, single-dose injection pens. It’s given as an injection under your skin.

What strengths does Zepbound come in?

Zepbound comes in six strengths:

  • 2.5 mg/0.5 mL
  • 5 mg/0.5 mL
  • 7.5 mg/0.5 mL
  • 10 mg/0.5 mL
  • 12.5 mg/0.5 mL
  • 15 mg/0.5 mL

What are the usual dosages of Zepbound?

Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. Starting with a low dosage allows your body to get used to the medication. This reduces the risk of having digestive side effects with Zepbound. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for weight loss and weight management

The typical starting dosage of Zepbound for weight loss is 2.5 mg injected once per week for 4 weeks. After this, your doctor will likely increase your dosage to 5 mg injected once per week for the next 4 weeks.

Your doctor may further increase your weekly dose in increments of 2.5 mg until you reach the dosage that’s right for you. Each time your doctor increases your dose, you’ll take the new dosage for at least 4 weeks.

The maximum dosage of Zepbound is 15 mg injected once per week.

Is Zepbound used long term?

Yes, Zepbound is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for you, you’ll likely use it long term.

The dosage of Zepbound you’re prescribed may depend on several factors. These include:

  • how your body responds to Zepbound
  • if you have bothersome side effects with Zepbound

Zepbound comes as a liquid solution inside prefilled, single-dose injection pens. It’s given as an injection under your skin. Your doctor or another healthcare professional will show you how to give yourself these injections at home.

You’ll inject Zepbound once per week, on the same day each week. You can inject your dose at any time of day. You can take a dose with or without food.

You can inject Zepbound in your thigh, belly, or the back of your upper arm. (If you want to inject into your upper arm, someone else will need to administer the injections.) To avoid irritating your skin, you should inject Zepbound in a slightly different spot each week.

For more detailed instructions on how to use Zepbound, see the printed medication guide that comes with your medication. The manufacturer’s website also has more instructions, including a video on how to inject Zepbound.

For information on the expiration, storage, and disposal of Zepbound, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

If you miss a dose of Zepbound, inject it as soon as you remember. But if it’s been more than 4 days (96 hours) since you were supposed to inject it, skip the missed dose. Then, inject your next dose at its usual time.

You should not inject two doses at once to make up for a missed dose. Also, do not inject two doses within 3 days (72 hours) of each other. Doing so can raise your risk of side effects.

If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

If you need help remembering to inject your dose of Zepbound on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Zepbound than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Zepbound

Call your doctor right away if you think you’ve injected too much Zepbound. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Zepbound’s dosage.

Is Zepbound’s dosage similar to the dosages of Wegovy?

The forms and how often you take each drug are similar. Zepbound and semaglutide (Wegovy) both come as liquid solutions inside prefilled injection pens. With either drug, you give yourself an injection once per week.

The dose in milligrams for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Zepbound to start working?

Zepbound starts to work after your first dose. But it may take a few weeks before you start to lose weight. Keep in mind that weight loss will also depend on your calorie intake and your exercise routine. Your doctor will monitor you during treatment to check whether your weight management plan is working for you.

If you have other questions about what to expect from your Zepbound treatment, talk with your doctor.

The sections above describe the usual dosages provided by the manufacturer. If your doctor recommends Zepbound for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Zepbound without your doctor’s recommendation. Only use Zepbound exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Will my Zepbound dosage depend on my BMI?
  • Should my Zepbound dosage be adjusted if I have side effects or become unwell during treatment?
  • Will my dosage be based on the amount of weight I lose during treatment?

To learn more about Zepbound, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.