Zenpep (pancrelipase) is a prescription drug that’s used to treat exocrine pancreatic insufficiency. Zenpep’s cost may depend on factors such as your dosage, whether you have health insurance, and the pharmacy you use.

Zenpep retail price
Save up to $67 per fill off of the retail price
The retail price of Zenpep is $1423. Save up to $67 per fill off of the retail price.

The price you pay for Zenpep can vary. Your cost may depend on your treatment plan, your insurance coverage (if you have it), and the pharmacy you use.

To find out how much you’ll pay for Zenpep, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Zenpep prescription, explore these Optum Perks coupons.

Save on Zenpep with Optum Perks

Save on Zenpep without insurance.

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40000unt zenpep (90 Capsules)

Save on Zenpep

Simply show the Optum Perks coupon at your preferred pharmacy and instantly save without using insurance. The coupon doesn't expire so be sure to save it for use with refills.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com


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Zenpep only comes as a brand-name drug. It’s not currently available in a generic version. A generic contains an exact copy of the active drug in a brand-name medication but tends to cost less.

Why is there such a cost difference between brand-name drugs and generics?

Years of research and testing are needed to ensure that brand-name drugs are safe and effective. This testing can make the drugs expensive. The manufacturer of a brand-name drug can sell the drug exclusively for up to 20 years. After that, other drugmakers can create generic versions. This competition in the market can lead to lower costs for generics. And because generics have the same active ingredients as brand-name drugs, they don’t need to be studied again. This can also lead to lower generic costs.

If you take Zenpep as a long-term treatment for exocrine pancreatic insufficiency, you may be able to lower your costs in the following ways:

  • Look into getting a 90-day supply of your medication. You may be able to get a 90-day supply of Zenpep if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of Zenpep. If you’re interested in getting a 90-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.
  • Use a mail-order pharmacy to get your medication. Using a mail-order pharmacy might help lower your cost for Zenpep. Plus, you could get your medication without leaving home. Some Medicare plans may help cover the cost of mail-order drugs. You may also be able to get a 90-day supply of the drug through mail order. If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need help covering the cost of Zenpep or understanding your insurance, check out these resources:

On these pages, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.

Below are answers to some frequently asked questions about Zenpep and cost.

How does the cost of Zenpep compare with that of similar drugs, such as Creon?

The cost of Zenpep compared with the cost of similar drugs, such as Creon (pancrelipase), can depend on several factors.

Factors that may affect how much you pay include:

  • whether there are any coupon cost-savings programs available for the drug you’re prescribed
  • whether you have insurance or are paying out of pocket
  • how long your treatment lasts
  • your dosage

If you have questions about the cost of Zenpep compared with the cost of similar medications, talk with your doctor, pharmacist, or insurance provider. They can share more details on treatment costs based on your specific situation.

Is Zenpep covered by Medicare?

It’s possible. Medicare Part D is Medicare’s prescription drug coverage. There are many different types of plans available, and your cost and coverage will depend on your individual plan benefits. To find out whether your plan covers the cost of Zenpep, call your plan provider.

Keep in mind that your plan may have prior authorization requirements before it will cover Zenpep.

You can also ask your doctor about the cost of Zenpep if you have Medicare.

How much does Zenpep cost without insurance?

What you’ll pay for Zenpep without insurance depends on several factors. Generally, your cost will be higher without insurance.

Factors that could affect your cost include:

  • your dosage
  • whether you qualify for any savings programs
  • the pharmacy you choose
  • the supply of medication you receive (such as a 30-day or 90-day supply)

To find out the exact cost of Zenpep without insurance, ask your doctor or pharmacist. Also, you may want to check with a few pharmacies to compare prices.

You can also visit Optum Perks* to get price estimates for Zenpep when you use coupons from the site. It’s important to note that Optum Perks coupons cannot be used with any insurance copays or benefits.

* Optum Perks is a sister site of Healthline.

If you have insurance, you may need to get prior authorization before your insurance provider will cover Zenpep. This means your insurer and your doctor will discuss Zenpep in regard to your treatment. Then the insurance company will determine whether the drug is covered. If Zenpep requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.

Be sure to ask your insurance company whether Zenpep requires prior authorization.

If you still have questions about the cost of Zenpep, talk with your doctor or pharmacist. They may be able to give you a better idea of what you’ll pay for this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for Zenpep.

Examples of questions you may want to ask your doctor or insurance provider include:

  • How does the cost of Zenpep compare with Pertzye (pancrelipase)?
  • Are there other more affordable medications available if I can’t afford Zenpep?
  • Does my dosage affect the cost of Zenpep?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.